Efeitos do hormônio do crescimento sobre vias de sinalização intracelular na miopatia associada à insuficiência cardíaca de ratos

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Tabela 13 - /

Variáveis Sham

(n=17)

EAo (n=13)

EAo-GH (n=10)

PC (g) 484 ± 42 415 ± 31* 476 ± 58#

VE (g) 0,839 ± 0,116 1,218 ± 0,257* 1,419 ± 0,244*

VD (g) 0,292 ± 0,056 0,499 ± 0,089* 0,601 ± 0,102*#

Átrios (g) 0,094 ± 0,016 0,330 ± 0,097* 0,386 ± 0,064*

Sóleo (g) 0,234 ± 0,030 0,189 ± 0,021* 0,209 ± 0,035

Gastrocnêmio (g) 2,783 ± 0,252 2,413 ± 0,219* 2,595 ± 0,315

VE/PC (mg/g) 1,733 ± 0,172 2,932 ± 0,567* 2,913 ± 0,460*

VD/PC (mg/g) 0,608 ± 0,134 1,204 ± 0,221* 1,234 ± 0,192*

Átrios/PC (mg/g) 0,195 ± 0,028 0,796 ± 0,233* 0,790 ± 0,106*

Pulmão (g) 2,167 ± 0,498 3,521 ± 0,757* 3,936 ± 1,178*

Pulmão/PC (mg/g) 4,528 ± 1,252 8,532 ± 1,956* 8,117 ± 2,739*

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PC (g) 508,4 ± 41,1 451,7 ± 89,7 466,7 ± 59,5

DDVE (mm) 8,08 ± 0,45 8,51 ± 1,10 8,64 ± 0,82

DDVE/PC (mm/kg) 15,98 ± 1,21 19,29 ± 3,70* 18,69 ± 1,98*

DSVE (mm) 3,77 ± 0,47 4,07 ± 1,24 3,86 ± 0,90

EDPP (mm) 1,47 ± 0,09 2,25 ± 0,34* 2,46 ± 0,24*

ESPP (mm) 2,98 ± 0,21 3,98 ± 0,34* 4,37 ± 0,72*

ESSIV (mm) 2,80 ± 0,19 3,05 ± 0,26* 3,44 ± 0,30*#

EDSIV (mm) 1,48 ± 0,08 2,26 ± 0,34* 2,48 ± 0,26*

AO (mm) 3,80 ± 0,21 3,91 ± 0,27 3,93 ± 0,37

AE (mm) 4,99 ± 0,34 7,82 ± 1,08* 7,72 ± 0,87*

AE/AO 1,32 ± 0,15 2,00 ± 0,28* 1,97 ± 0,21*

AE/PC (mm/kg) 9,88 ± 1,07 17,79 ± 3,73* 16,68 ± 1,93*

Esp Rel VE 0,35±0,03 0,52±0,11* 0,53±0,04*

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5/

Tabela 3 % & !- 0 -

Variáveis Sham (n=17)

EAo (n=13)

EAo-GH (n=10) FC (bpm) 287 ± 41 299 ± 34 299 ± 40

ǻ Endo (%) 53,4 ± 4,4 53,0 ± 9,5 55,5 ± 8,5

ǻ Meso (%) 30,3 ± 3,1 28,7 ± 4,3 29,5 ± 3,9

VEPP (mm/s) 37,0 ± 2,5 27,8 ± 4,6* 28,7 ± 6,3*

Onda E 73,2 ± 7,0 140,7 ± 13,8* 121,7 ± 17,5*

Onda A 47,5 ± 6,7 34,3 ± 23,4* 25,1 ± 6,0*

E/A 1,58 ± 0,35 4,86 ± 1,31* 5,25 ± 2,03*

TDE (ms) 50,1 ± 6,9 33,2 ± 8,4* 33,9 ± 10,6*

TRIV (ms) 31,06±5,44 24,08±7,61* 20,57±6,32*

TRIVn (ms) 33,1 ± 4,4 23,0 ± 4,7* 19,3 ± 5,2*

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Tabela 4 %- !- #0 -

(n=15)

EAo (n=13)

EAo-GH (n=08)

PC (g) 484 ± 42 415 ± 31* 476 ± 58#

DDVE (mm) 7,73 ± 0,53 7,93 ± 1,42 7,98 ± 1,02

DDVE/PC (mm/kg) 15,54 ± 1,45 18,47 ± 3,20* 16,53 ± 3,62#

DSVE (mm) 3,16 ± 0,51 4,08 ± 1,74 3,20 ± 0,91

EDPP (mm) 1,43 ± 0,09 2,25 ± 0,25* 2,41 ± 0,37*

ESPP (mm) 3,03 ± 0,21 3,79 ± 0,48* 4,33 ± 0,63*

ESSIV (mm) 2,80 ± 0,19 3,05 ± 0,26* 3,44 ± 0,30*#

EDSIV (mm) 1,45 ± 0,08 2,26 ± 0,24* 2,40 ± 0,35*

AO (mm) 3,9 ± 0,1 4,1 ± 0,2* 4,0 ± 0,2

AE (mm) 4,9 ± 0,2 7,0 ± 0,8* 7,8 ± 1,2*

AE/AO 1,28 ± 0,06 1,74 ± 0,19* 1,92 ± 0,30*

AE/PC (mm/kg) 9,89 ± 0,79 16,22 ± 1,68* 15,87 ± 2,08*

Esp Rel VE 0,37±0,03 0,58±0,10* 0,62±0,16*

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Tabela 5

_{% & !- #0 -}

(n=15)

EAo (n=13)

EAo-GH (n=08)

FC (bpm) 303 ± 43 298 ± 27 308 ± 21

ǻ Endo (%) 59,1 ± 5,6 49,8 ± 14,7* 59,8 ± 12,1#

∆ Meso (%) 32,8 ± 3,2 26,6 ± 7,9* 31,6 ± 6,3

VEPP (mm/s) 38,6 ± 7,2 25,2 ± 5,1* 25,6 ± 3,1*

Onda E 74,2 ± 8,5 132,4 ± 15,7* 121,1 ± 19,0*

Onda A 54,5 ± 15,9 26,0 ± 5,0* 22,6 ± 5,8*

E/A 1,45 ± 0,37 5,23 ± 0,97* 5,59 ± 1,31*

TDE (ms) 52,6 ± 4,3 32,7 ± 4,8* 29,0 ± 5,9*

TRIV (ms) 33,12±4,18 23,57±4,70* 21,31±5,77*

TRIVn (ms) 33,9 ± 4,3 22,9 ± 5,0* 21,4 ± 5,5*

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