Estudos estruturais da Purina Nucleosídeo Fosforilase do Mycobacterium tuberculosis complexada com ligantes

Marcos Michel de Souza

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Gostaria de agradecer, somente a Deus.

Agradeço a Deus por todas as pessoas que ele colocou no meu caminho durante minha vida acadêmica.

Agradeço a Deus pela vida da minha orientadora de iniciação científica, Maria da Piedade Rezende da Costa, que me ensinou os primeiros passos da vida acadêmica e me apoiou a vinda para a Biofísica.

Piedade costuma dizer que o orientador é o pai acadêmico do aluno, e eu tenho muito a agradecer a Deus por essa grande família que ele me deu. Todos foram muito importantes na minha vida, minha orientadora Dra. Fernanda Canduri e meu co-orientador Dr.Walter Filgueira de Azevedo Júnior, e todos os meus irmãos acadêmicos que eu tanto amo: minha querida e sincera Alessandra Renata, o dedicado e inteligentíssimo Márcio Vinícios, meus camaradas Paulo Camilo e Rodrigo Galo, Janaína, Helen, e todos os demais.

Agradeço a Deus por ter colocado em minha vida professores muito especiais, aos quais hoje tenho o mais profundo afeto e admiração: Dr. José Ruggiero, meu colega do coral que tanto me fez sofrer na disciplina “Forças Intermoleculares”, Dr. Eslso Drigo Filho, com sua gargalhada inconfundível, Dr. Jorge Chaíne, o coordenador da pós, que sempre me atendeu prontamente todas as vezes que precisei de sua ajuda, e a todos os outros professores, do departamento.

Agradeço a Deus pelos amigos que fiz no Departamento e por todas as pessoas que me ajudaram, minha amiga Cristiane, a sempre simpática Dona Rose, a prestativa Ilva, o Paulinho e o Barbosa sempre atenciosos.

Graças a Deus pelas agências de fomento à pesquisa CAPES e FAPESP sem as quais esse trabalho não seria possível.

Sou grato a Deus meus amigos de fora da Unesp, que também sempre me incentivaram nesta carreira: José Precioso Júnior, Anderson Rodrigues Silva, Fabiano Ferreira Ângelo, e ao meu grande amigo Thiago Laurêncio Rizzo.

Dou graças a Deus também pela vida do meu pai e minha mãe, que sempre lutaram para que eu pudesse estudar e sempre me deram incentivo para seguir na carreira acadêmica.

Agradeço a Deus até mesmo pelas pessoas que me fizeram algum mal, pois até as dificuldades me fizeram crescer.

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60 – 180kDa

Homo Sapiens E. Coli, Salmonella

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Inosina, Guanosina e Adenosina Inosina e Guanosina Inosina, Guanosina e Adenosina

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Variada, exceto homo-hexâmeros Homotrímeros Homohexâmeros

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