Volume 4 Supplement 2 September 2010
BMC
Proceedings
Abstracts of the 16th International
Charles Heidelberger Symposium on
Cancer Research
Volume 4 Supplement 2 September 2010
BMC
Proceedings
Abstracts of the 16th International Charles Heidelberger
Symposium on Cancer Research
Coimbra, Portugal
26-28 September 2010
Committees
The Organization of the 16th International Charles Heidelberger Symposium on Cancer Research acknowledges the support of: • FCTUC (Faculdade de Ciências e Tecnologia da Universidade de Coimbra)
• CIUC (Centro de Informática da Universidade de Coimbra)
• DIIC-UC (Divisão de Identidade, Imagem e Comunicação da Universidade de Coimbra) • Turismo de Coimbra
• Turismo Centro de Portugal • Bentham Science Publishers
International Advisory Committee
Eli Huberman (USA) Johan Lillehaug (Norway) Joseph Landolph (USA) Karl Heinrich Link (Germany) Robert Langenbach (USA) Toshio Kuroki (Japan)
Symposium Executive Committee
Eli Huberman (USA) Johan Lillehaug (Norway) Joseph Landolph (USA) Karl Heinrich Link (Germany)
Secretariat
Ana Paula Parreira
Symposium Chairs
Carlos Freire de Oliveira (Portugal) Joseph Landolph (USA)
Eli Huberman (USA) Maria Carmen Alpoim (Portugal)
Local Organizing Committee
Ana Castro Jardim (FMUC) Joana Felício Cerveira (FCTUC)
Ana Daniela Sampaio (FCTUC) Leonardo Manuel Ferreira (FCTUC)
Ana Margarida Urbano (FCTUC) Luís Miguel Pires (FMUC)
António Jorge Guiomar (FCTUC) Maria Carmen Alpoim (FCTUC)
Armando Cristovão (FCTUC) Maria Filomena Botelho (FMUC)
Carlos Freire de Oliveira (FMUC) Marta Pinto Coelho (FMUC) Isabel Maria Abrantes (FCTUC) Paula Vasconcelos Morais (FCTUC) Isabel Marques Carreira (FMUC)
Local Programme Committee
Ana Margarida Urbano (FCTUC) Maria Carmen Alpoim (FCTUC)
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Volume 4 Supplement 2 September 2010
BMC
Proceedings
Contents
Opening Lecture
O1 Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networks
Curtis C. Harris
Session 1 - Cancer Etiology and Epidemiology
O2 Gene-environment in the induction of cancer
Herman Autrup
O3 Gene variants and lung cancer risk
Nina E Landvik, Shanbeh Zienolddiny, Vidar Skaug, Aage Haugen
O4 Polychlorinated biphenyls (PCB), UV radiation, and cutaneous malignant melanoma
Richard P Gallagher, Tim K Lee, Jean-Philippe Weber, Alain Leblanc, Marilyn Borugian, J Mark Elwood, Amy C MacArthur, Zenaida Abanto, John J Spinelli
P1 Abstract not submitted for publishing
P2 Association between night shift work, melatonin and estradiol in nurses
Beata Peplonska, Agnieszka Bukowska, Jolanta Gromadzinska, Wojciech Sobala, Edyta Reszka, Jenny A S Lie
P3 Mastermind-like 1 (MAML-1) as a new metastatic marker in esophageal squamous cell carcinoma
Mohammad M Forghanifard, Moein Farshchian, Reza Raeisossadati, Mohammad N Forghani, Meysam Moghbeli, Hussein Naseh, Mohammad R Abbaszadegan
P4 Polymorphisms of GSTM1, GSTT1, GSTP1 and CYP1A1 genes and susceptibility to lung cancer
Paula Mota, Michelle Horta, Luis Mesquita, Henriqueta Silva
P5 Obesity and breast cancer: inflammatory and adipocytokine correlations
Paulo C Matafome, Ana L Gomes, Manuel Gomes, Lélita C Santos, Ana B Sarmento, Raquel F Seiça
P6 Polymorphisms of estrogen receptors, ERα and GPR30: association with breast cancer susceptibility and prognosis
Susana M Alves, Luís Mesquita, Rita Sousa, Fátima Peralta, Henriqueta C Silva
P7 Breast cancer and environmental factors
J Vicente Paulo, Lélita Santos, Graça Fernandes
P8 Primary bone lymphoma
C Pissarro C Azevedo, P José A F F Tavares, M Isabel P Portela, A José L C P Santos, J Manuel P S Casanova
Session 2 - Molecular Carcinogenesis
O5 Regulation of DNA damage responses by mismatch repair
Anatoly Zhitkovich
O6 Insoluble Ni compound-induced gene amplification/gene silencing causes over-expression of microtubules/microfilaments, cell shape changes, and de-regulation of global gene expression/Ca+2 gradients, inducing morphological/ neoplastic transformation of
10T1/2 mouse embryo cells
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O7 The bioenergetic signature of cancer
José M. Cuezva
O8 Roles of beta-arrestin1/2 in prostaglandin-mediated signaling and tumor development
Robert Langenbach, Huei-Chen Lao, Kyung-Soo Chun
O9 PINK1/BRPK inhibits apoptotic cell death and enahances cellular invasiveness through an activation of mTORC2 pathway
Hitoshi Murata, Masakiyo Sakaguchi, Ken Kataoka, Nam-ho Huh
O10 Receptor for activated C-kinase (RACK1) plays a central role in Ras-mediated signal transduction
Johan R Lillehaug, Line M Myklebust, Arnt Raae, Bodil Bjørndal
P9 The role of CD26 and CD40 expression in therapeutic response - experimental study in oral cancer lines
Joana P N Batista, Sílvia S Neves, A Cristina Gonçalves, Vera Alves, Ana Sarmento-Ribeiro, Marília Dourado
P10 Abstract not submitted for publishing
P11 Evaluation of the role of miR-34b in modulation of radioresistance in non-small cell lung cancer
Joana B Silva, Sílvia S Neves, A Cristina Gonçalves, Margarida Marques, Luís Mesquita, Filomena Botelho, A Bela Sarmento-Ribeiro, Henriqueta C Silva
P12 P-cadherin expression in feline mammary tissues
A Catarina Figueira, Júlio Carvalheira, M Manuela Lacerda, M Fátima Gärtner
P13 Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer?
Cláudio J Maia, Cátia V Vaz, Carina G Peres, Cecília R A Santos, Sílvia Socorro
P14 MicroRNA-21 in lung cancer: overexpression in metastasis of pulmonary adenocarcinomas and squamous cell carcinomas
Maria R Silva, Paulo Santos, Isabel Velada, Catarina Gomes, M João d’Aguiar, Lia Teixeira, João Dinis, Susana Carmona, Luisa Cortes, Lina Carvalho
P15 Involvement of mitochondrial and survival signaling in berberine-induced apoptosis in melanoma cells
Ana Burgeiro, Consuelo Gajate, El H Dakir, Paulo J Oliveira, Faustino Mollinedo
P16 Metabolic changes in human bronchial epithelial cells upon chronic exposure to hexavalent chromium
Leonardo M R Ferreira, Maria S Santos, M Carmen Alpoim, Ana M Urbano
P17 Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypes
Ana Sampaio, Luís Mendes, Ana C Gonçalves, Margarida Abrantes, Ana B Sarmento, Filomena Botelho, Paulo Oliveira, Vilma Sardão, Rui Carvalho, Ana M Urbano and M Carmen Alpoim
Session 3 - Tumor Microenvironment and Tumor Cell Biology
O11 Tumor Microenvironment Controls the Rate of Cancer Progression and Metastasis
Raghu Kalluri
O12 Metabolism and metastasis: in the bone marrow and beyond
Sérgio Dias
O13 The Immune Biology of Microsatellite Unstable Cancer
Magnus von Knebel-Doeberitz
O14 Targeting secreted heat shock protein-90alpha (Hsp90α) to prevent breast cancer progression
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O15 JAKs and STATs in Chemoresistance
Ana Costa-Pereira
O16 Autophagy turns specific: the discovery of p62 and NBR1 as autophagy cargo receptors
Geir Bjørkøy
P18 Abstract not submitted for publishing
P19 Abstract not submitted for publishing
P20 Relation between autophagy and the resistence of glioblastoma cells to temozolomide
Anália Carmo, Helena Carvalheiro, Maria C Lopes
P21 GLUT expression and 18F-FDG uptake in breast cancer cell lines
Ana M Abrantes, Mónica Martins, Ana C Gonçalves, Maria C Rodrigues, Ana C Mamede, Sónia D Tavares, José M Lima, Adriano Rodrigues, Ana B Sarmento-Ribeiro, Maria F Botelho
P22 MDR modulation in colorectal adenocarcinoma cell lines: kinetic studies using 99mTc-sestamibi
João Casalta-Lopes, A Margarida Abrantes, Joana Rio, Mafalda Laranjo, Bárbara Oliveiros, A Cristina Gonçalves, Ana B. Sarmento-Ribeiro, M. Filomena Botelho
P23 Phenotypic analysis of breast cell lines – triple negative cells vs expressing hormonal receptors
Mafalda Laranjo, Maria J Carvalho, Artur Paiva, A Margarida Abrantes, Isabel Torgal, Carlos F Oliveira, M Filomena Botelho
P24 Abstract not submitted for publishing
P25 A nonconjugated naphthalene derivative of meso-tetra-(3-hydroxy)-phenyl-porphyrin as a sensitizer for photodynamic therapy
Abílio J F N Sobral, Ana M Urbano, Pedro Silva, Sofia M Fonseca, Cláudia T Arranja, Hugh D Burrows
P26 Polyaromatic hydrocarbons accentuate malignant phenotype of the PC3 prostate cancer cell line
Mariana O Freitas, José Oliveira, Ana M Fernandes, Maria I Coutinho, Vera Alves, Anabela Mota-Pinto, Ana B Sarmento-Ribeiro
P27 MGBG–cisplatin combination chemotherapy against breast cancer
Raquel F Gonsalves, Maria P M Marques
P28 Melanoma skin cancer: could chromone derivatives be efficient chemopreventors?
Mafalda M Dias, Maria P M Marques
P29 Exosomes from human ovarian carcinoma SKOV3 cells are enriched in glycosylated proteins
Cristina Escrevente, Peter Altevogt, Júlia Costa
P30 Delocalized lipophilic cations as a new therapeutic approach in cancer
A Barbosa Ribeiro, A Luísa Ferreira, A Cristina Gonçalves, Sílvia Neves, A Maria Araújo, Filipa Carvalho, João Carvalho, Rui M Santos, Vera Alves, Teresa Silva, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P31 Cytotoxic effect induced by combination of polyamines metabolites and endocannabinoid, anandamide, on human cancer cells: a new anticancer strategy
A Lúcia M Batista-de-Carvalho, G Tempera, N Viceconte, S Saccoccio, E Bidollari, M Nalli, Enrico Morera, Giorgio Ortar, Enzo Agostinelli
P32 An in vitro tumor-fibroblast interaction model of human oral squamous cell carcinoma
Jozséf Dudás, M Bitsche, V Schartinger, G M Sprinzl, H Riechelmann
P33 Physiologic parameters variation in ICR mice during a chemical induced liver carcinogenesis experiment
Ivo Conceição-Pereira, Nuno M Paula-Santos, Filipa O Pereira, Maria J Pires, Luis F Palomino, Aura A Colaço, Paula A Oliveira
P34 Role of VEGF signalling in the regulation of KDR expression in endothelial and tumoral microenvironment
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P35 EP4-mediated prostanoid signalling promotes oral cancer progression
Karen Sapienza, Stewart Sale, Angela Hague, Ian.R. Hart, J.ohn F. Marshall, Gareth.J. Thomas
P36 Role of notch pathway and HNF1 in cell death induced by HDACs inhibitors in ovarian cancer cell lines, serous and clear cells
Fernanda Silva, Jacinta Serpa, Germana Domingues, Gabriela Silva, António Almeida, Ana Félix
P37 TRAP1 and SORCIN cooperate in a survival pathway responsible for inducing drug-resistance in human colorectal carcinoma (CRC)
Matteo Landriscina, Francesca Maddalena, Gabriella Laudiero, Maria R Amoroso, Annamaria Piscazzi, Valentina Lombardi, Alberto Fersini, Franca Esposito
P38 Dll4 blockade interferes with the bone marrow vascular niche and perturbs hematopoietic recovery following myeloablation
Leonor Remédio, Tânia Carvalho, Sérgio Dias
P39 Short-chain sphingolipids for enhanced cellular uptake of liposome-encapsulated amphiphilic anti-cancer drugs
Lília R C Pedrosa, Albert van Hell, Wim van Blitterswijk, Ann L B Seynhaeve, Alexander M M Eggermont, Timo L M ten Hagen, Marcel Verheij, Gerben A Koning
P40 Osteosarcoma contains a subpopulation of cancer stem-like cells that are highly resistant to radiotherapy
Sara R M Neves, Aurio O G Lopes, Anália do Carmo, Antero J Abrunhosa, Paulo C P S Simões, Artur A Paiva, M Filomena Botelho, Célia M F Gomes
P41 Indentification of cancer stem-like cells in osteosarcoma and their implications in response to chemotherapy
Áurio O Lopes, Sara R Neves, Anália do Carmo, Artur A Paiva, Maria Botelho, Célia M Gomes
P42 Metabolic responses of A549 lung cells to cisplatin and radiation exposure studied by 1H NMR spectroscopy Ana F Ladeirinha, Inês D Lamego, Ana M Gil, Joana B Melo, Isabel M Carreira, Iola F Duarte
P43 In vivo pulmonary metastatic profile of breast cancer cell lines expressing hormonal receptors versus triple negative
M João Carvalho, A Margarida Abrantes, Mafalda Laranjo, Francisco Falcão, Sofia Cabrita, M Filomena Botelho, Carlos F de Oliveira, Isabel Torgal
P44 New targeted therapies in myelodysplastic syndrome: the role of farnesyltransferase and proteasome inhibitors
A Cristina Gonçalves, Ana Oliveira, Diana Moreira, Silvia Neves, Vera Alves, Teresa Silva, Luís Mesquita, Henriqueta Coimbra, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P45 Targeted gene silencing for cancer treatment
Lígia C G da Silva, José S Ramalho, M Conceição P de Lima, Sérgio Simões, João N Moreira
P46 Recombinant trail: a synergistic effect in myeloid leukemias
Filipa Carvalho, A Sofia Coelho, Cátia Domingues, João A Carvalho, André Ribeiro, Rui M Santos, A Cristina Gonçalves , Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P47 Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?
Ana S Ribeiro, Laura C Carreto, André Albergaria, Bárbara Sousa, Sara Ricardo, Fernanda Milanezi, Raquel Seruca, Manuel A Santos, Fernando Schmitt, J oanaParedes
P48 Contribution of Thomsen-Friedenreich antigens to bladder cancer malignancy: Characterization of cell line models
Paulo F Severino, Mylène A Carrascal, Helena Gouveia, M Guadalupe Cabral, Manuela Correia, Nadia Malagolini, Mariella Chiricolo, Fabio Dall’Olio, Paula AVideira
P49 Antitumoral effect of farnesiltransferase and mtor inhibitors in hepatocellular carcinoma: in vitro studies
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P50 Metalloproteinase inhibitors as a potential therapeutic approach in multiple myeloma: a preliminary study
A Sofia Pais, A Cristina Gonçalves, Catarina Geraldes, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P51 Novel antitumor DNA monoalkylating agents: Synthesis and biological evaluation
Ana F Brito, M Isabel Soares, Mafalda Laranjo, A Margarida Abrantes, José A Paixão, Ana M Beja, Manuela R Silva, Teresa P Melo, M Filomena Botelho
P52 The effect of cisplatin in 5637 bladder cancer cell line
Rosário Pinto-Leite, Regina Arantes-Rodrigues, M Luís Cardoso, Lúcio Santos, Paula A Oliveira
Session 4 - Cancer Genetics and Epigenetics
O17 CDH3/P-cadherin overexpression in breast carcinomas: its regulatory mechanisms, the role in cell invasion, and the association with cancer stem cell properties
Joana Paredes
O18 Spontaneous development of lung adenocarcinoma in the CADM1 gene-deficient mice
Masayoshi Nagata, Mika Sakurai-Yageta, Daisuke Yamada, Taketo Kawai, Yumi Tsuboi, Takeshi Ito, Akihiko Ito, Midori Yoshida, Yoshinori Murakami
O19 The FRAGILOME project, a strategy for the discovery of new gene biomarkers in cancer
Manfred Schwab
O20 Gene amplification in breast cancer – looking for the molecular mechanisms
Sergei Kovalenko
O21 Molecular Genetic Study of Female Cancers in Novosibirsk, Russia
Lyudmila F Gulyaeva
O22 E-cadherin mediated cellular effects and molecular partners. Gastric cancer as an invasive model
Joana Figueiredo, Joana Simões-Correia, Joana Fernandes, Ana R Mateus, Gianpaolo Suriano, Joana Paredes, Carla Oliveira, Raquel Seruca
P53 Identification of copy number variations of chromosomes 7, 9 and 10 in human glioblastomas by SNP-arrays
Inês Crespo, Maria D Tabernero, Ana B Nieto, Olinda Rebelo, Hermínio Tão, Fernando Gomes, Catarina R Oliveira, Maria C Lopes, Alberto Orfao
P54 Circadian gene variants and MT6s level in nurses under different work shifts – preliminary results
Edyta Reszka, Beata Peplonska, Edyta Wieczorek, Jolanta Gromadzinska, Wojciech Sobala, Wojciech Wasowicz, Agnieszka Bukowska, Jenny A Lie
P55 MFSD2A is a novel lung tumour suppressor gene whose expression is modulated by a 5’-region polymorphism
Francesca Colombo, Monica Spinola, Felicia S Falvella, James P Sullivan, David S Shames, Luc Girard, Paola Spessotto, John D Minna, Tommaso A Dragani
P56 FGFR4 GLY388ARG polymorphism modulates cancer patients’ survival in pooled analysis
Elisa Frullanti, Tommaso A Dragani
P57 KRAS and EGFR mutations coexisting in lung adenocarcinoma
Vitor Sousa, Ana Alarcão, Patricia Couceiro, Maria R Silva, Maria J d’Aguiar, Lia Teixeira, Lina Carvalho
P58 Modulation of DNA damage prevention and signaling pathways in diet induced colon cancer prevention
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P59 MIR-143 over-expression reduces the growth of xenograft tumors from colon carcinoma cells
Pedro M Borralho, Sofia Gomes, Raquel T Lima, Rui E Castro, Maria H Vasconcelos, Cecília M P Rodrigues
P60 Histone deacetylation - a new epigenetic target in cancer
João A Carvalho, Emília Cortesão, José D Branco, Ana C Gonçalves, Sílvia Neves, Filipa Carvalho, André Ribeiro, Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P61 EGFR unusual mutation status in lung adenocarcinomas
Ana Alarcão, Vitor Sousa, Patrícia Couceiro, Maria Silva, Maria J. d’Aguiar, Lia Teixeira, Lina Carvalho
P62 Identification of a common deletion region in 10q26 associated with human gliomas
Margarida Alves, Paulo Liberato, Ana Rita Conde, Manuela Mafra, Alexandra Inverno, Ana Teresa Maia, Denise Bagrel, Isabel Carreira, Miguel Brito, Carolino Monteiro
P63 STEAP1 expression in prostate cancer and its regulation by androgens
Inês Gomes, Cecília R A Santos, Sílvia Socorro, Carlos Lopes, Cláudio J Maia
P64 EGFR/erb-1, HER2/erb-2, CK7, LP34, Ki67 and p53 expression in preneoplastic lesions of bronchial epithelium
Lina Carvalho, Joana E Santo, Ana Alarcão, Patricia Couceiro, Maria R Silva, Ana Gomes, Maria J d’Aguiar, Lia Teixeira, Vitor Sousa
Session 5 - Translational Cancer Medicine
O23 Quality control in colon and rectal cancer surgery
Karl-Heinrich Link
O24 Detecting tumor responses to treatment using hyperpolarized 13C magnetic resonance spectroscopic imaging Kevin M Brindle
O25 Tumor-tailored treatment of colorectal cancer: from bench to bedside?
Marko Kornmann
O26 Targeting non-viral vectors to tumor cells and the tumor microenvironment
Vera Moura, Manuela Lacerda, Paulo Figueiredo, M Luísa Corvo, M Eugénia M Cruz, M Conceição P. de Lima, Sérgio Simões, João N Moreira
O27 Adjuvant therapy in colorectal cancer – studies of the FOGT group
Ludger Staib, Marko Kornmann, Karl-Heinrich Link
O28 “Omic” landscapes of breast cancer - the end of the beginning
Carlos Caldas
O29 Bacterial anticancer weapons: a promising tool to fight cancer
Ananda M Chakrabarty
P65 Improving the classification of brain tumors in mice with perturbation enhanced (PE)-MRSI
Rui V Simões, Sandra Ortega-Martorell, Teresa Delgado-Goñi, Yann le Fur, Marti Pumarola, Ana P Candiota, Patrick J Cozzone, Margarida Juliá-Sapè, Carles Arús
P66 NMR metabonomic study of lung cancer: metabolic profiling of tissues
Cláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vítor Sousa, Lina Carvalho, Iola F Duarte
P67 NMR metabonomic study of lung cancer: metabolic profiling of urine and blood plasma
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