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Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways.

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Academic year: 2017

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Figure 1. Schematic of components required to implement the new vision of toxicity testing in the 21 st century ( needs permission from NRC TT21C report )
Figure 2. Comparison of current (A) and proposed (B) toxicity testing paradigms. The current approach (Panel A) to setting regulatory standards involves interpretation of the most sensitive end point observed in animal studies
Figure 4. Stress response pathways and network motifs. (A) Typical structure of a stress response pathway (adapted from Simmons et al
Figure 5. p53-mediated perturbation of DNA damage response pathways that affect mutagenesis

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