Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.

To test whether DZNep affects TRAIL signaling in various NHL B-cell lymphoma-derived cell lines, we investigated apoptosis induced by treatment with TRAIL in cells pre-treated

Taken together, our data show that the ability of Mtb to induce IL-1 b secretion was PYCARD, NLRP3, and caspase-1 dependent in human THP-1 cells as well as primary mouse

Increased IL-6 expression, activation of STAT3 in colon tissue, and S100A9 in isolated colonic epithelial cells (CECs), from.. a mouse model of dextran sulfate sodium

Our results demonstrated that this novel compound induced apoptosis of oral cancer cells either in the in vitro cell culture or in the in vivo xenograft tumor mouse model.. In

As shown in Figure 4 B and C, macrophages and dendritic cells from the CRM-0019-infected mice showed reduced numbers of lung and spleen IL-12 and TNF a producing macrophage

In conclusion, we show that peroxide is involved in TRAIL-induced apoptosis in human pancreatic cancer MiaPaCa-2 cells, and that both peroxide and superoxide play regulatory roles

In this study, by ectopic expression of OCT4B in SiHa cells we demonstrated that OCT4B promoted cervical cancer cell proliferation and xenograft growth, and inhibited cell

Because we found that the combined treatment with casticin and TRAIL strongly induced cytotoxicity in gastric cancer cells, we next examined the effect of the treatment on