Latin
Latin American American Cancer Cancer Survival Survival Study
Study (LATINCARE Project): (LATINCARE Project):
Cervix
Cervix Cancer Cancer
National
National School School of Public of Public Health Health Oswaldo Cruz
Oswaldo Cruz Foundation Foundation, , Ministry Ministry of Health of Health , , Rio de Janeiro,
Rio de Janeiro, Brazil Brazil
Sergio Koifman
Contents Contents
Antecedents Antecedents
LATINCARE: methods and objectives LATINCARE: methods and objectives
Data collection and analysis Data collection and analysis
Perspectives Perspectives
Objetivos
• Obter estimativas quantitativas e comparáveis da sobrevida de câncer na América Latina para o
câncer de colo uterino a partir de dados
individuais de Registros de Câncer de Base Populacional, fornecidos segundo padrões acordados e centralmente analisados.
• Comparar as estimativas obtidas de sobrevida
para o câncer de colo uterino na America Latina.
Data collection
• Incident cases diagnosed in selected years between 1995-2001
• Invasive cervical cancer
• 5-yrs follow-up (active search)
• Observed & relative survival ascertainment
Data Analysis
• Central data analysis carried out at the
National School of Public Health/Fiocruz,
Ministry of Health, in Rio de Janeiro.
Cancer Registries
Latincare Coordination
•Cancer database in a specific format
•Population database file
•Mortality database file
Summary report with the checking results
Survival analysis
•Organize database
• Data inconsistencies, missing and minimum follow-up checking
•IARC Check
Latincare
1 BEHAVIOUR_RECODE
Behaviour recode
TYPE OF FOLLOW-UP EXPECTED 1 Type Follow-up_expected
CAUSE OF DEATH (ICD10) 4 CAUSE_DEATH (CID10)
ICD CODE 1 ICD_CODE
FOLLOW-UP_STATUS 1 follow-up status
YEAR_ LAST FOLLOWUP 4 ANO_STATUS VITAL
MONTH_LAST FOLLOWUP 2 MÊS_STATUS VITAL
CODING_EXT_DISEASE 1 coding_Exte_disease
1 DIAG_CONFIRMATION
Diag_confirmation
HISTOLOGY ICD0-3 4 MORFOLOGIA
PRIMARY SITE 3 PRIMARY SITE
INDIC_TUMORES MULTIPLOS 2 INDIC_TUMORES MULTIPLOS
YEAR_DIAGNOSTIC 4 ANO_diagn
MONTH_DIAGNOSTIC 2 mês_diagn
EXTENSÃO DA DOENÇA 1 EXTENSÃO DOENÇA
SEX 1 SEXO
RACE 2 RAÇA
AGE AT DIAGNOSIS 3 IDAD_DIAG
YEAR_BIRTH 4 ANO_NASC
MONTH_BIRTH 2 MÊS_NASC
COUNTRY 3 PAIS
TYPE OF REPORTING SOURCE 1 TYPE_REPORT_SOURCE
PATIENT_ID 8 IDENTIFICACÃO _PACIENTE
REGISTRY 2 REGISTRO
LENGHT VARIAVEIS_SEER
VARIAVEIS _LATINCARE
LATINCARE I
1,0 0,5
Deaths 1 month of follow- up
8,3 1,6
DCO
26,4 18,3
Losses before 4 yrs follow-up
87,0 86,6
Histopathological confirmation
0,0 1,2
Reported date inconsistency
2,0 Multiple tumors 4,4
6,0 Unknown vital status 10,9
0.5 Unknown birthday and age 1,6
Lima (1997) N = 724
(%) Goiânia(1997-1999)
N = 437
(%)
Evaluation Parameters
4362 1995-1998
Ecuador Quito
4943 1995-2000
Costa Rica
724 119 409 1997
2000 1996-2001 Peru
Metropolitan Lima Arequipa
Trujillo
101 63 124 1998
2001 2001 Argentina
Prov. Buenos Aires Prov. Rio Negro Prov. Entre Rios
432 1187
203 460 306 200
115 1997-1999
1997 1999 1997 1998 1994-1995
1998-2000 Brazil
Goiânia São Paulo
Belém-Ananindeua Rio de Janeiro
Brasília Campinas
Chile
Valdivia
Cervical cancer cases Year of Diagnosis
Cancer Registries
Five Years Relative Survival of Cervix Cancer, Valdivia-Chile,1998-2000
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
12 24 36 48 60
months
Relative Survival
all ages
< 40 years 40 a 59 years
> 60 years
Five Years Relative Survival of Cervix Cancer, Goiânia-Brazil,1997-1999
0%
20%
40%
60%
80%
100%
12 24 36 48 60
months
R el at iv e S u rv iv al
all ages
< 40 years 40 a 59 years
> 60 years
Five years Observed Survival Curve Cervical Cancer, Lima, Peru - 1997
0%
20%
40%
60%
80%
100%
1 2 3 4 5
years
all ages
< 40 40 a 59
>60
5-yrs relative survival of cervical cancer diagnosed in 1998, Buenos Aires Province,
Argentina
0 20 40 60 80 100 120
12m 24m 36m 48m 60m
< 40 años 40-59 años
≥ 60 anos
todas las edades
Observed survival curve for < 40 years
< 40 years
0,00%
20,00%
40,00%
60,00%
80,00%
100,00%
120,00%
12 24 36 48 60
Months
Obs. Survival BELEMCAMPINAS
GOIANIA LIMA
RIO NEGRO VALDIVIA
Observed survival curve for 40 -59years
40-59 years
0.00%
20.00%
40.00%
60.00%
80.00%
100.00%
12 24 36 48 60
Months
Obs. Survival BELEM
CAMPINAS GOIANIA LIMA
RIO NEGRO VALDIVIA
Observed survival curve for > 60 years
> 60 years
0,00%
20,00%
40,00%
60,00%
80,00%
100,00%
12 24 36 48 60
Months
Obs. Survival BELEMCAMPINAS
GOIANIA LIMA
RIO NEGRO VALDIVIA
Observed survival, all ages
0,00%
20,00%
40,00%
60,00%
80,00%
100,00%
12 24 36 48 60
Months
Obs. Survival BELEMCAMPINAS
GOIANIA LIMA
RIO NEGRO VALDIVIA
0 20 40 60 80 100 Campinas
Belem Lima Valdivia Rio Negro Goiania B. Aires
Relative Survival (%)
51.4 (3.8) 47.5 (3.5)
206 1999
Belém
50.1 (5.5) 44.2 (5.2)
95 1994-1996
Campinas
73.1 (2.7) 68.7 (2.5)
369 1997-1999
Goiania
57.5 (5.0) 54.5 (4.7)
112 1998-2000
Valdivia
53.5 (2.2) 50.0 (2.6)
648 1997
Lima
69.5 (7.3) 67.8 (7.1)
44 2001
Rio Negro
Rel. Surviv.(%) (SE%)
Obs Survival (%) (SE%)
N Year of
Enrollment Cancer Registry
5-years Observed and Relative Survival,
all ages (LATINCARE)
Perspectives
• Other cancer sites:
- breast (in progress) - childhood cancer - stomach
- colorectal
- lung
Coordinators,
Participating Population-Based Cancer Registries
• Adolfo Ortiz, National Cancer Registry, Costa Rica
• Antonio Mirra & Maria Rosario Latorre, Sao Paulo, Brazil
• Elza Martinez, Brasilia, Brazil
• Fernand Bernard Corral, Quito, Ecuador
• Luis Eduardo Bravo, Cali, Colombia
• Luis Medina, Arequipa, Peru
• Jorge Caceres, Antofagasta, Chile
• Maria Enriqueta Bertran, Valdivia, Chile
• Maria Neves Mussio, Belem-Ananindeua, Brazil
• Maria Paula Curado & Jose Carlos de Oliveira, Goiania, Brazil
• Miguel Angel Prince, Entre Rios Province, Argentina
• Nazira Mahayri, Campinas, Brazil
• Paul Pilco & Patricia Perez, Lima, Peru
• Pedro Albujar, Trujillo, Peru
• Ruben Kowalyszyn, Rio Negro Province, Argentina
• Silvia Bonicatto, Buenos Aires Province, Argentina
