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Gla-Rich Protein Is a Novel Vitamin K-Dependent Protein Present in Serum That Accumulates at Sites of Pathological Calcifications

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Academic year: 2021

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Figure 1. Rat GRP gene is highly expressed in nonskeletal tissues. Sites of gene expression were determined by in situ hybridization with  digoxigenin-labeled antisense probes in outer ear paraffin sections, and signal was revealed with alkaline phosphatas
Figure 2. Rat GRP is highly accumulated in cartilage (A, B, F), bone (C), skin and its appendages (D and E), and in the vascular system (G–J) as  deter-mined by immunohistochemistry using the CTerm-GRP primary antibody and peroxidase-conjugated goat anti-r
Figure 3. Gla proteins detection co-localize in rat skin and cartilage with GRP accumulation
Figure 4. GRP is present in human skin (A–F) and vascular system (G–I). A–C: Sites of GRP expression determined by in situ hybridization with digoxigenin-labeled antisense probes (blue) in healthy human skin
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