Prognóstico em osteossarcoma: análise clínica, epidemiológica, histopatológica e imuno-histoquímica

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Emilio Carlos Curcelli

PROGNÓSTICO EM OSTEOSSARCOMA:

análise clínica, epidemiológica, histopatológica e imuno-histoquímica

Tese apresentada à Faculdade de

Medicina de Botucatu - Unesp para

obtenção do título de doutor em

Bases Gerais da Cirurgia

Botucatu

2008

(2)

Emilio Carlos Curcelli

PROGNÓSTICO EM OSTEOSSARCOMA:

análise clínica, epidemiológica, histopatológica e imuno-histoquímica

Tese apresentada à Faculdade de

Medicina de Botucatu – Unesp para

obtenção do título de doutor em Bases

Gerais da Cirurgia.

Orientador: Prof. Dr. Sérgio Swain Müller

Co-orientadora: Profa. Dra Anete Kinumi Ueda

Botucatu

2008

(3)

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Dedicatória

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Curcelli EC. Prognóstico em osteossarcoma

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Agradecimento

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Curcelli EC. Prognóstico em osteossarcoma

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Curcelli, EC. Prognóstico em osteossarcoma

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Curcelli EC. Prognóstico em osteossarcoma

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Abstract

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Curcelli EC. Prognóstico em osteossarcoma

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Curcelli EC. Prognóstico em osteossarcoma

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Sumário

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Curcelli EC. Prognóstico em osteossarcoma

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Curcelli EC. Prognóstico em osteossarcoma

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Introdução

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Curcelli EC. Prognóstico em osteossarcoma

24

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Revisão da literatura

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GGGGGGGGjóGt SGGXS]aGXUGrGGUG OX`_`PGGíéGGXS]aGXGGGtGGUGOYWW[PSGGXSX\aGXUG zGGUGOX`^\PSG{ GGUGOX`_\PSGwGGUGOX``XPGG nGGUGOX``ZPGGGGGGGGUG jGGt GGUGOX``YPSGz¡GGUGOYWWWPSGtGGUGOYWW[PG GiGGUGOYWW]PSGGGGGéGGGùGGG GGUG G YUZGss¡íéGGG G vGG¡TSGGĂSGGûG çG G G ðG G çG G G óUG vG G G éGGGSGGGĂGGðSGóSGĀGGóG O|TiG G USG X`^^bG zSG X`_YbG oSG X``XbG tG G USG YWW[PUG

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zGGUGOYWWZPGGGGðGGðGGG G G ðG ïG G G G G G G GGGGX\WSGGùUG {GGGðGGGGíéGG G G SG G G SG G G G GGùUGuéGçSGGSGGGGèG GGGGGGGéGSGGGçGG G G ùSG G G ïG G íéG éG éG UG kG G SG G G G G SG éG ïG óG ¡G GéGGóGçGGçUGG G YU\GjjíéG G zGGíéGGSGTGGGG ûGGGóSGùGGGùG UG xG æG ¡íéG G SG G G G G GGGGïGOz¡SGX``ZPUG vGGGGéGGSGGGG G `WLG G G OmG MG tSG X``ZbG kG G UG YWW^PUG lG G SG ùG G ùSG G ¡éG G íéG ùG G G íéG ùG SG G G TïUG jSG G ĀG çG G íéG G ïG G G G G G G ¡G GG GOz¡SGX`_YPUG vG G ùG G G G éaG çSG çSG çSG çSG G G ïGGTùGGGOz¡SGX``ZPUGGG uG G çSG G ¡G G ïG G G ùG G ùUG uG çSG G G G G G G

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zG y G G UG OYWWYPSG G G çG G G G \WLG G SG G G çG G G çG GGG\WLSGGGGY\LUGGG

wG OYWW\PG G _XSZLG G G G G G èGçSGXXS]LSGçGGZSZLSGçUG

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G G OmG MG tSG X``ZPUG iG G UG OX`_`PG G zG G UG OX`^`PGGGGGGïGGðGGùG GGGUGlSGGh GGUGOX`_`PSGG ùGïGGGGGUGG vGGTùGGGGG G XLG G G G G G G G G ùG OoSG X``XbGmGMGtSGX``ZbG~GGUSGYWWYbGkGGUSGYWW^PUG wGwGGUGOX``^PSG{GGUGOX```PSGy GGUG OYWWWPSG iG G UG OYWW]PSG G éG G G G G SG G G G G èG ùSG éG ïG ĀG G G G ùUG z

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vG G G G G G G ðG G ùG G G G G G G OrG G USG X`_`bG oSG X``XbG mG MG tSG X``ZbG z¡SG X``ZbG h G MG j¡SG YWWYbG |G MG rSG YWWYPUG vG G G G G G óSG G SG GGGùGGGGGO~GGUSG X`_[PUG vG çG éG G G G G G G G G ïTG G G íG G wSG íéG G G ûG OtG G USG X`_`PUG {ðG G ùG G G G G G G éG G G ùG OrG G USG X`_`bG mG G USG YWWYPUG zG mG G UG OYWWYPSG G ðGGGçGæGGGGZS[LGG \S\LG G G G SG G íûG G G íGGwGGGWS^GGWS`LGGUGkGGUGOYWW^PG GXS^LGGðGGGçSGGG GGíUGG

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G YU]GlG G vGGGGéGGGGG ðSG G íéG G G G ïG G G G G G G G íéG G G G G OlSGX``ZPUG vGGGGïGGGGlGGGG X`_WGGtG{Gz GOlSGX`_ZPGGGhG qG jG G jG zG G lG yG yG OoG G UG X`_`bGkGGUSGYWWYPUG lG G G ðG óG G G aGnSGGGíéGùbG{SGGGGúbGGtSGGG íG G ðG G çUG wG ðG óG G G G G pSG ppG G pppSG G G hSG G G GGiSGUG

kG G G oG G UG OX`_`PSG G G G éG G G G G ĀTïSG SG ZWLG SGGùSGGGçGpbG]WLSGGçGppGGXWLSGG çG pppUG vG G ĂSG G çG pSG éG G G O]]LPSGGSGGçGppSGéGGGO`WLPUGG wG G G G G çG pppG OíG çPSGGùSGGGùGGSGGGSG G G G G G ðG G G OiG G USG X``_SG YWWWbG ~G G USG YWWWbG w÷TnG G USG YWWZbG tG G USG YWW[bGyGGUSGYWW[bGtGGUSGYWW\bGt{GGUSGYWW]bGwGG USGYWW]PUGxGGGGGçSGGûGéGG GGĂGGOsGGUSGX`_]PUG

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Prognóstico em osteossarcoma: análise clínica, epidemiológica, histopatológica e imuno-histoquímica

Emilio Carlos Curcelli

PROGNÓSTICO EM OSTEOSSARCOMA:

análise clínica, epidemiológica, histopatológica e imuno-histoquímica

Tese apresentada à Faculdade de

Medicina de Botucatu - Unesp para

obtenção do título de doutor em

Bases Gerais da Cirurgia

Botucatu

2008

Emilio Carlos Curcelli

PROGNÓSTICO EM OSTEOSSARCOMA:

análise clínica, epidemiológica, histopatológica e imuno-histoquímica

Tese apresentada à Faculdade de

Medicina de Botucatu – Unesp para

obtenção do título de doutor em Bases

Gerais da Cirurgia.

Orientador: Prof. Dr. Sérgio Swain Müller

Co-orientadora: Profa. Dra Anete Kinumi Ueda

Botucatu

2008

Dedicatória

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Agradecimento

Curcelli EC. Prognóstico em osteossarcoma

Agradecimento

Curcelli EC. Prognóstico em osteossarcoma

Curcelli, EC. Prognóstico em osteossarcoma

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Abstract

Curcelli EC. Prognóstico em osteossarcoma

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Sumário

Curcelli EC. Prognóstico em osteossarcoma

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Curcelli EC. Prognóstico em osteossarcoma

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Introdução

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Revisão da literatura

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Curcelli EC. Prognóstico em osteossarcoma

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Curcelli EC. Prognóstico em osteossarcoma

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Revisão da literatura

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Curcelli EC. Prognóstico em osteossarcoma

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