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Design and synthesis of aminoxanthone derivatives as promising disruptors of p53:MDM2 interaction

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Academic year: 2021

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Figure 1 - Crystal structure of self-assembled p53 tetramer bound to DNA (PDB code 3KMD)
Figure 4 – Similarity of structural domains of MDM2 and MDMX oncoproteins (adapted from 11 )
Figure 5 - Regulation of p53 by MDM2 and MDMX through autoregulatory feedback loop
Figure 6 – Crystal structures of p63 (PDB code 1RG6) and p73 (PDB code 1COK).
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