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5th
Portuguese Young
Chemists Meeting
(5th PYCheM)
&
1st
European Young
Chemists Meeting
{1st EYCheM)
Centro Cultural Vila Flor
Guimaraes, Portugal
COMMITTEES
ORGANIZING COMMITTEE
Catarina Cust6dio (3B's Research Group) Lufsa Rodrigues (3B's Research Group) Joi!o Borges (3B's Research Group) Ana Rita Araujo (3B 's Research Group) Sara Amorim (3B' s Research Group) lvo Aroso (3B's Research Group) Raquel Teixeira(3B's Research Group) Rarnon Novoa-Carballal (3B's Research Group)
Ana Soares (Chemistry Department of University ofMinho) Cristina Sousa (Chemistry Department of University ofMinho) Tiago Silva (3B's Research Group)
Lara Reys (3B 's Research Group) Sandra Silva (3B' s Research Group) Leonardo Mendes (SPQ)
SCIENTIFIC COMMITTEE
Joilo F. Mano (Univ. do Minho, Portugal) lva Pashkuleva (Univ. do Minho, Portugal) Femanda Proen~ (Univ. do Minho, Portugal) Artur Silva (Univ. de Aveiro, Portugal) Ant6nio Femando Silva (Univ. do Porto, Portugal) Maria Joa:o Moreno (Univ. de Coimbra, Portugal)Ver6nica Bermudez (Univ. de Tn\s os Montes e Alto Douro, Portugal) Matilde Marques (Inst. Superior Tecnico, Portugal)
Isabel Ferreira (Inst.Politecino de Bragan~a, Portugal) Arrnando Silvestre (Univ. de Aveiro, Portugal) Jose Esperan~a (ITQB, Portugal)
Ant6nio Varandas (Univ. de Coimbra, Portugal) Fatima Bento (Univ. do Minho, Portugal) Aranzazu del Campo (MPIP Mainz, Germany) Radim Hrdina (Univ. ofPardubice, Czech Republic) Edward Matthijs (KU Leuven, Belgium)
SPQ SECRETARIAT
Leonardo Mendes Cristina Campos5th PYCheM & 1st EYCheM- 2016 Guimaraes, Portugal
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26 April 27 April 28 April
RegistratiOn and
Workshop of Organic
Inorganic, Physical,
9:00- Open Sc1ence and Chemistry and
13:20 European Open Medicinal Analytical and
Access Policies in Chemistry Electrochemistry
H2020
13:30 Operung Ceremony Lunch Lunch
CHEM2NATURE Symposmm Chelllical
strategies for modification of natural ongm matenals Biochemistry and 14:00. Green Chemistry + Medicinal 18:00 Chemistry of Chemistry Natural Products Assembleia GQJ (17h) 18:00 Walking Tour 19:00
J
Welcome Cocktail21:30 Get-together mght Gala Dmner
29 April Materials Chemistry and Nanomaterials and Surface Chemistry Lunch Materials Chemistry and Nanomaterials and Surface Chemistry Closmg Ceremony 11
27th
April
PU • Nuno Maulide (50+ 10)
I
8h30 "'Oreanic synthesi' with rearrangemeDts: catalrsit ofunusual bond formino reaction:.!'t
OPIO· Novel Metal-Free Approach to Promising 09h30 COX-2 Inhibitors via Bronsted Acids-Catalyzed
Decomposition of Diazofuranones
Organic Chemistry Dmilrii Semeuok (10+5)
OPII· Luminescent Boranils and Boron-diketonates 09h45 +
Samuel Guieu (10+5) Medicinal Chemistry
OP12· Synthesis ofcopper(II) complexes of
!OhOO Chair: Dr. Fernanda Proen~a aJ)'lhydrazone and their application as catalysts in
oxidation of cycloalkanes in different media Young chair: Raquel Ribeiro Seixas Gon~alo
Antunes de Oliveira Tia2o 00+5) OP13-A novel strategy towards a regioselective
one-10hl5 pot synthesis of azaindoles
Marina Joana Dias Pires (lO+S) OP14· Functionalization oflnternal Alkynes: A New 10h30 Approach to 1,2-Disubstituted Cyclopentadienes
Nikola Topolovcan (10+5)
10h45 Coffee break+ Poster session
IL4. Artnr Siba (30+5)
llh!S "Greener heating methodJ in the oynthesis of biolotrlcally active heterocvclic compounds"
OP15 ·Application of Cinchona-alkaloids
llh50 Organocatalysts Pathway to in an Novel Rivastigmine and Efficient Synthetic SOvia Domin2os Fernandes (10+5) OP!6-Modular Oxindole Synthesis-a General an
Efficient Rhodiunt-Catalysed Addition of
12h05 Arylboronic Acids to !satin-Derived
N-Boc-Protected
··Carolina Silva Marques (10+5)
OP17-Iridium Catalyzed Asymmetric
12h20 Organic Chemistry Hydrogenation ofQninoline and Derivatives Quinoxaline
+ Tahar Ayad (10+5)
Medicina I Chemistry OP 18-Novel Fluorescent Organic Salts based on
12h35 Chair: Dr. Armando Silvestre Cationic or Anionic Dyes Andreia Sofia de Almeida Baptista Forte Young Chair: Silvia Domingos Fernandes (10+5)
OP 19-Candidacidal potential of licorice phenolic 12h50 extract: emphasis on its mode of action
Natalia Ana Pereira da Cruz Martins{lOill
OP20- Development oflntegrated S}stems for
Extraction and Purification ofMonoclonal 13h05 Antibodies directly from CHO Cell Cultures
Emanuel Auguato Vieira Capela (10+5)
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14h20 15h20 15h35 15h50 16h05 Biochemistry 16h20 + Medicinal Chemistry16h35 Chair: Vitor Gaspar Young chair: Filipa Joilo Femandes Gomes 16h50
17h05
17h35
!ShOO
PL3 - Helder Santos (Sll+ I 0) "Bridging between engineering and medidne
-Current applications of nanomedicines for cancer,
diabetes and cardiovascular diseases'' OP21- Development of new anti-bacterial agents
Carolina dos Santos Vina~:reiro (10+S) OP22- Synthesis of Anticancer Symmetric
Bis(N-alkylaniline)triruylmethanes via Friedel-Crafts-Catalyzed Reaction between
Secondary Anilines
Rafael Filine Teixeira Arbnez Goems (10+5} OP23- Identification oflnhibitors and Mechanisms
oflnhibition ofProtein Tyrosine Phosphatases -Potential Therapeutical Targets in Various
Pathological Disorders Knban-Jankowska Alicja (10+5) OP24- Anticancer activity and molecular signalling of potent chemotherapeutics- 2-methoxyestradiol and
fulvestrant in therapy of osteosarcoma Magdalena Gorska (111+5} OP25- Action of new porphyrin conjugates with
potential anti-malaria activity on membranes SofJa Ines Leal Dnarte (10+5} OP26- Self-assembled polymer-metal micelles: new
promising anticancer agentes Leonor de Sa No~:ueira Corte-Real (10+5}
PYCAAward (10+5)
IL5 - Moria Joiio Moreno (30 + 5) "Importance of passive processes in cholesterol
homeostasis- absorption at the intestine and distribution in the blood" Coffee Break + Poster Session
Walking Tour
OP19 • Candidacidal potential of licorice phenolic extract: emphasis on its mode of action
Natfllia Martins u Sofia Costa-Oliveira '·Jsabel C F R Ferreira 1 S6nia Sjlva 2' Mariana Heruiqyes 2 Corresponding Author: [email protected]
1 Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Braganra, Campus de Santa Apol01tia, ]]72, 5301-855 Braganra. Portugal.
2CEB, Centre of Biological Engineering, UBRO-Laboratorio de Investigariio em Bioftlmes Rosdrio
0/iveira, University of Minho, 4710-057 Braga, Portugal.
3Departmenl of Microbiology, Faculty of Medicine, Porta University, Alameda Professor Hemani
Manteira, 4200-319 Porta, Portugal.
Medicinal plants bave gained a special attention in the last years, due to its renowned health benefits, such as antimicrobial effects [I]. In fact, several natural matrices bave been increasingly studied, namely for its antifungal activity against opportunistic fungi [2,3]. Candida species, although commensa! microorganisms, have caused severe organic dysfunctions to the host, once current antifungal agents have lost their recognized efficiency [2]. So, numerous studies have been carried out focusing the mechanisms of acquired drug-resistance by Candida species [<Hi]. However, apart from the discovery of an efficient multi-drug therapy (i.e. chemical drugs and also natural extracts combination), the discovery of the involved mechanisms of actions, morphological changes and related kinetic parameters are of major
importance. Glycyrrhiza glabra L. (licorice) hydromethanolic extract have evidenced promissory
candidacidal effects, and therefore, the involved mechanisms of action need to be clarified. Thus, in the present study these modes of action were assessed, by using flow cytometry.Overall, the licorice extract induced significant and irreversible primary damages on Candida cells, being membrane disruption and
consequent unviability one of the main targets. In fact, after membrane destabilization, cells lost their
proper homeostasis, their metabolic functions were blocked and, consequently cells lost functionality. The relevance and interest of the achieved results open new insights towards the upcorning use of the present phenolic matrix, being important to evaluate its in viva efficacy. Therefore, further studies are necessary to deepen knowledge on this field, aiming not only to establish therapeutic and prophylactic doses, but also to improve the clinical intervention in Candida infections.
References
[I] Sher, A., Gomal J. Med. Sci. 2009, 7, 72--78.
[2] Martins, N.; Ferreira, I. C. F. R; Barros, L.; Si!va, S.; Heruiques, M., Mycopathol2014, 177, 223-240. [3] Martins, N.; Barros, L.; I. C. F. R., Ind. Crops Prod. 2015, 74,648-670.
[4] Kanafani, Z. A.; Perfect, J. R, C!in. Infect. Dis.-Antirnicrob. Resist. 2008, 46, 120-128.
[5] Sang!ard, D.; Odds, F. C., Lancet Infect. Dis. 2002, 2, 73-85.
[6] White, T. C.; Holleman, S.; Dy, F.; Laurence, F.; Stevens, D. A.; Mirels, L. F., Antimicrob. Agents
Chemother. 2002, 46, 1704-1713.
Acknowledgments The authors acknowledge FCT (Portugal) for financial support to CIMO
(PEst-OE/AGUI0690/2014) and N. Martins grant (SFRHIBD/87658/2012).
