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Determinants of cell-to-cell variability in protein kinase signaling.

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Academic year: 2017

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Figure 1. Cell-to-cell variability in a minimal model of a gradual kinase cascade. A Schematic representation of a five-step kinase cascade (S…extracellular stimulus; X i and X i  …active and inactive kinases, respectively; P i …phosphatases; k a,i and k d
Figure 3. Cell-to-cell variability of kinase cascades with distributed ultrasensitive switching
Figure 4. Cell-to-cell variability of cascades with a localized switch at the terminal level
Figure 1B). C Variabilities of K m,5 (defined as the stimulus for a half-maximal pathway activation) and X max,5 were analyzed using the IQRatio, and the activation resistance was tuned by varying several phosphatase rate constants (k d,2 – k d,4 , thick,
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