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Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin

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Academic year: 2021

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Fig. 3. Cx43-containing EVs loaded with dox decrease the activation of signalling pathways related to cell motility
Fig. 4. EVs loaded with dox have anti-tumoural activity in 4T1 luc2 tumour-bearing mice
Fig. 5. EVs loaded with dox inhibit tumour growth in vivo. Representative serial BLI of mice bearing bilateral 4T1 luc2 subcutaneous tumours before treatment (at day 5), and at days 8 and 11 after cells inoculation, corresponding to 3 days after the first
Fig. 6. Cx43-containing EVs ameliorate dox cardiotoxicity in vivo. Tumour-bearing mice were treated (i.t.) with 0.2 mg/kg of free dox, EV Cx43  dox or EV Cx43  dox 5 and 8 days after bilateral subcutaneous 4T1 luc2 cells inoculation

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