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Structural basis for the pathophysiology of lipoprotein(a) in the athero-thrombotic process

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Academic year: 2019

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Figure 1 - Structural homologies between apolipoprotein(a) and plasminogen. Lp(a) shares its  li-pid composition and  apolipopro-tein B-100 with low density  lipo-proteins (LDL)
Figure 2 - Representation of the cDNA sequence of human apolipoprotein(a). The apo(a) gene contains a hypervariable region encoding a variable number (n = 1 to ~40) of kringles 4 type 2 that determines the existence of several apo(a) isoforms
Figure 3 - Plasminogen activa- activa-tion by t-PA on fibrin and by  pro-urokinase on cell surfaces is the major mechanism of defense against thrombosis
Figure 4 - Competitive inhibition of the binding of plasminogen by Lp(a). Inhibition of plasmin generation results in  accumula-tion of fibrin, cholesterol and smooth muscle cells on the  vas-cular wall.
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