Estudo in vivo do cimento de fosfato de cálcio acrescido de "whiskers" de Wollastonita : um novo biomaterial

Texto

(1)2324562789248 4

(2) 7 24 1 1 1. 01 1. 4 4 4 4 444544445 !"4 2"#"44$%&'#(44%!!)4743*4 +#!4 4 4 4. 4 4 1 1 1 1. 1 1. 1. 1 14 5,-4./011 01.

(3) 001 1. 1. 001.

(4) 0001 1. 1. 1 1. 0001.

(5) 2012 2. 2 2. 2 2. 2 2 2 2 2 2. 2 012.

(6) 01 1. 1 1. 1. 1 01.

(7) 012 2. 2. 012.

(8) 021212 2. 3456782 9. 2

(9) 1 11 2 2 211 2210 2 22

(10) 1 12102 22 20102 2 22 2 !2"21# 21 22

(11) 1 11 2$2 1 2 22 2 2%&1% 2'2 2 2% 1#1% 22 $ 21 (201 2

(12) 1 10 201 %&1% 22%&1% 22# # 22%%1 !2" 2)&1% 2 2* # 22)%1 2 2 2

(13) 1011 22+1 ,11222)1 2* # 22 )%1 2-)*).!2 2)*)22 2 % 22 2#%121 2%%122

(14) 22 1 22 $ !2/ 2 2 2)*)22 2 2 1 2% 2 12 1 2 12

(15) 1,2%122#2% 2 2 2!2202# 2 2 )*)2 2#1

(16) 2% 2 22%

(17) 2122%

(18) 2$2 1 211 !2 21 2 2# 2 2 2121 3 42'2% 2#1

(19) 21 2% !2/ 2 2# 12 11 22)*)22

(20) 22567)02# 2% 2121 3 4228 122 01 %&1%2 2% , 2-)91 :.2'2 12% 2 201 2

(21) 1 10 2# 22 %221 ,112 21 2#12 2 22%1 2;% !22 2

(22) ;10 2 2 2# 120122

(23) 1 % 1

(24) 1122 2% 2 2)*)2% %1 22 121 3 4228 12<=>?<?@!202

(25) 2 2%1 2 2 22AB7)02% 2 2 2CDE22121 3 4228 12# 21%1 222 2' 2% 2 FGE22 22/F+0 H2-# # 22 1 2

(26) 1

(27) 1% 21 .!2 2

(28) 1 12 2 2 # 222 22'2# 12 2 2#1 2%I1% 22G221 2 2 2 122 281 !2* 211 2:D2 21011 22 1 2 !2 211 2 2%

(29) 2 2122567)02- 27)0.22 2 2%

(30) 2122567)02 % %1 22CD2E22121 3 4228 12- 27)08.!2)1% 211 22%2 2# 2 1 2 2 22:D2JD22CFD21 !2" 2%01 2# 21 22

(31) 1 22 % 21 1% 2% 2K 122+ ,112271%L1 22 M !2"21 2 # N1%2# 1212% 2,I1 2 2 #22OPQRSTUVU=WX(2 "0%2Y %2:!D2 2'2# 12 I02 2222 2 # 2 2 1# 2I 22 !2 2 2, 22N12222 2 # 2 2 27)022-F2FGE.2-FZDE.22-FJ:E.2 2:D2JD22CFD21 2 22 1 2 %10!2/ 2 27)082222 2 # 2# 122HG:E2 2:D21 2G2DZE2 2JD21 22:[\E2 2CFD21 !20201 2% %1%22 2 2%1 22 2 2

(32) 1 12 2%01 22CFD21 2# 2

(33) 1 2 2 2. 0112.

(34) 201112 2. 345678852972 674

(35) 5265 2741952972194515256287272522 647861952972 2972!"#18$748%2972&5 8'51' 2(2 2 '74 '10 201)0723 4 277# 41 2'7619 2887 *2 35182872 58'452+1565 3 '072726 3 ,297278'1 42 275-54

(36) 52887 2 ./0/12/345467/1894:15 '741 18*2-58- '529726)615272"5 8'51' 2 2 2 2 2. 2. 01112.

(37) 012 2. 345673869 9. 0

(38) 0 2 22202 0 2 2 2 020 00202 20 2 0 2022 02 2 20 2202!02 20

(39) 0 2 22 02002

(40) 02 2 22 0020 22"20 02 2 2

(41) 02 2

(42) 02 2 0

(43) 2 2#2 0

(44) 2 2

(45) 02 22 0020 2$ 1 02 2 0

(46) 2% 2

(47) 2&'(2#2'2 22 002 202 2 02 02 2 0 2 20

(48) 0 2 2 02 $ )2'2 202022 2 20

(49) 2 202 2 )2 2 2

(50) 2 2 2 2# 20 2'2 202

(51) 02 2 02 22 2* 22 20

(52) 2 22+)0!+2 2

(53) 022 202,2 022)22 2'- 2.-#%20 2)02+)0!+2 2/ 02 2

(54) 02

(55) 12& 0012(2 2 20 02 2

(56) 2 2 2 2 1 020

(57) 2 0!022 2 2 0202#2 0

(58) 2 2022) 2 2 22 0

(59) 0002 22 0 2 2'2 2+)0!+2 2/ 02020 2# 2 022

(60) 2 )2 2.-#%2)02 2)0 23452+)0!+2 2/ 02) 2 2 2 2 6 2 0 2 002782)529 7$%1:2&0 02 0

(61) 2 2 (2#20

(62) 0 2022

(63) 20 2 2 2)02) 2 2022 00 22 282

(64)

(65) 2202/0 2 2 0 2 2/22242 20020 2) 2 2#202 2020

(66) 0 2 2.-#%2&#%2 (2 22 2 020

(67) 0 2 2.-#%2 23452 2+)0!+2 2/ 02&#%/2 (2 '02 0

(68) 2

(69) 2 2 2)2 02)002242;42 23742 2#2 0 2 )2

(70) 2 22 20 0 2 02)02

(71) 102 2 02 2< 2 #0

(72) 2#2

(73)

(74) 02 02) 2

(75) 2029,0-=

(76) 2 ) "2 * 2> 224202)0202) 2 02 2

(77) 22 2 2)2

(78) 2 2 022020 2 20

(79) 2#2212 2 2 2 2)2

(80) 2 2022#%2 2&72785(2&7?45(2 2&7;25(2 2242;42 23742 2 2 0

(81) 0 202#%/2 2022 2 2)2 2

(82) 0 2) 2:8252 2 2242824?52 2;42 2 22@A52 23742 2' 2

(83) 02 0 2 2202 2 222 220

(84) 0 2 0 23742 2)2B2 2

(85) 0 2 2)02$ 2% 102 2 22.#%2 23452 2+)0!+2 2 2. 012.

(86) 01 11. 23445673897 196151 95

(87) 4 1547 8579 13 1

(88) 38 17966 1 898. 981

(89) 56 197163 1

(90) 933579

(91) 4 158155

(92) 4 131679457981

(93) 38 13 579381 11 !"1#9357 9546$154913657 15813445673897 1 1. 1. 01.

(94) 0212 2. 3456789.

(95) 87949

(96)

(97)

(98)

(99)

(100)

(101)

(102)

(103)

(104)

(105)

(106)

(107)

(108)

(109)

(110)

(111)

(112)

(113)

(114)

(115)

(116)

(117)

(118)

(119)

(120)

(121)

(122)

(123)

(124)

(125)

(126)

(127)

(128)

(129)

(130)

(131)

(132)

(133)

(134)

(135)

(136)

(137)

(138)

(139)

(140)

(141)

(142)

(143)

(144)

(145)

(146)

(147)

(148)

(149)

(150)

(151)

(152)

(153)

(154)

(155)

(156)

(157)

(158)

(159)

(160)

(161)

(162)

(163)

(164)

(165)

(166)

(167)

(168)

(169)

(170)

(171)

(172)

(173)

(174)

(175)

(176)

(177)

(178)

(179)

(180)

(181)

(182)

(183)

(184)

(185)

(186)

(187)

(188)

(189)

(190)

(191)

(192)

(193)

(194)

(195)

(196) .

(197) 8747

(198)

(199)

(200)

(201)

(202)

(203)

(204)

(205)

(206)

(207)

(208)

(209)

(210)

(211)

(212)

(213)

(214)

(215)

(216)

(217)

(218)

(219)

(220)

(221)

(222)

(223)

(224)

(225)

(226)

(227)

(228)

(229)

(230)

(231)

(232)

(233)

(234)

(235)

(236)

(237)

(238)

(239)

(240)

(241)

(242)

(243)

(244)

(245)

(246)

(247)

(248)

(249)

(250)

(251)

(252)

(253)

(254)

(255)

(256)

(257)

(258)

(259)

(260)

(261)

(262)

(263)

(264)

(265)

(266)

(267)

(268)

(269)

(270)

(271)

(272)

(273)

(274)

(275)

(276)

(277)

(278)

(279)

(280)

(281)

(282)

(283)

(284)

(285)

(286)

(287)

(288)

(289)

(290)

(291)

(292)

(293)

(294)

(295)

(296)

(297)

(298)

(299)

(300) . !"#$$" . %&'(')$!"!"#$$" *. +,$-"')$-"./0$ 1. ,$$2)34"50-6)7786)0"$) 9. +,$$2)34":0!""0!6)' ;. <="7)-6)$ >. <?'2)@"$2)-"6A'"BC%DE . <F"'')$-"0-) .

(301) 9GH8I93

(302)

(303)

(304)

(305)

(306)

(307)

(308)

(309)

(310)

(311)

(312)

(313)

(314)

(315)

(316)

(317)

(318)

(319)

(320)

(321)

(322)

(323)

(324)

(325)

(326)

(327)

(328)

(329)

(330)

(331)

(332)

(333)

(334)

(335)

(336)

(337)

(338)

(339)

(340)

(341)

(342)

(343)

(344)

(345)

(346)

(347)

(348)

(349)

(350)

(351)

(352)

(353)

(354)

(355)

(356)

(357)

(358)

(359)

(360)

(361)

(362)

(363)

(364)

(365)

(366)

(367)

(368)

(369)

(370)

(371)

(372)

(373)

(374)

(375)

(376)

(377)

(378)

(379)

(380)

(381)

(382)

(383)

(384)

(385)

(386)

(387)

(388)

(389)

(390)

(391)

(392)

(393)

(394)

(395)

(396)

(397)

(398)

(399)

(400)

(401)

(402)

(403)

(404)

(405)

(406) . +,8J-K"$L6)$ . +,8J-K"$:$MN2"$ . *

(407) 578 5O993

(408)

(409)

(410)

(411)

(412)

(413)

(414)

(415)

(416)

(417)

(418)

(419)

(420)

(421)

(422)

(423)

(424)

(425)

(426)

(427)

(428)

(429)

(430)

(431)

(432)

(433)

(434)

(435)

(436)

(437)

(438)

(439)

(440)

(441)

(442)

(443)

(444)

(445)

(446)

(447)

(448)

(449)

(450)

(451)

(452)

(453)

(454)

(455)

(456)

(457)

(458)

(459)

(460)

(461)

(462)

(463)

(464)

(465)

(466)

(467)

(468)

(469)

(470)

(471)

(472)

(473)

(474)

(475)

(476)

(477)

(478)

(479)

(480)

(481)

(482)

(483)

(484)

(485)

(486)

(487)

(488)

(489)

(490)

(491)

(492) *. <D6M)6)34"!"$="7)-6)$ *. <57M')0-50-6)P#$$" Q. <+:(-)0A$),8-034"!"$:$M&7$ 9. <<R 6"$"M)!'(S ;. <T?0A'$R"62"7&-6) ;. <UR)6)34" >. <V?0A'$:$-)-N$-) >. Q

(493) 73493

(494)

(495)

(496)

(497)

(498)

(499)

(500)

(501)

(502)

(503)

(504)

(505)

(506)

(507)

(508)

(509)

(510)

(511)

(512)

(513)

(514)

(515)

(516)

(517)

(518)

(519)

(520)

(521)

(522)

(523)

(524)

(525)

(526)

(527)

(528)

(529)

(530)

(531)

(532)

(533)

(534)

(535)

(536)

(537)

(538)

(539)

(540)

(541)

(542)

(543)

(544)

(545)

(546)

(547)

(548)

(549)

(550)

(551)

(552)

(553)

(554)

(555)

(556)

(557)

(558)

(559)

(560)

(561)

(562)

(563)

(564)

(565)

(566)

(567)

(568)

(569)

(570)

(571)

(572)

(573)

(574)

(575)

(576)

(577)

(578)

(579)

(580)

(581)

(582)

(583)

(584)

(585)

(586)

(587)

(588)

(589)

(590)

(591)

(592)

(593)

(594) . T?0A'$R)6"$WM)!"$!2-"$W$$"$. T?0A'$!$6-K)!"$.6(M"$!+X!)$ . T+?0A'$!$6-K)!"$.6(M"$!YX!)$ . T<?0A'$!$6-K)!"$.6(M"$!X!)$ . T?0A'$R"62"7&-6) . T+?0A'$:$-)-N$-) 1. T+L6(M"C%D+X!)$Z[%D"7\]$^6$!\"'')$-"0-)+X!)$ 1. T+L6(M"C%DYX!)$Z[%D"7\]$^6$!\"'')$-"0-)YX!)$ 1. T++L6(M"C%DX!)$Z[%D"7\]$^6$!\"'')$-"0-)X!)$ 9. 1

(595) 83_4339

(596)

(597)

(598)

(599)

(600)

(601)

(602)

(603)

(604)

(605)

(606)

(607)

(608)

(609)

(610)

(611)

(612)

(613)

(614)

(615)

(616)

(617)

(618)

(619)

(620)

(621)

(622)

(623)

(624)

(625)

(626)

(627)

(628)

(629)

(630)

(631)

(632)

(633)

(634)

(635)

(636)

(637)

(638)

(639)

(640)

(641)

(642)

(643)

(644)

(645)

(646)

(647)

(648)

(649)

(650)

(651)

(652)

(653)

(654)

(655)

(656)

(657)

(658)

(659)

(660)

(661)

(662)

(663)

(664)

(665)

(666)

(667)

(668)

(669)

(670)

(671)

(672)

(673)

(674)

(675)

(676)

(677)

(678)

(679)

(680)

(681)

(682)

(683)

(684)

(685)

(686)

(687)

(688)

(689)

(690)

(691)

(692)

(693)

(694)

(695)

(696)

(697)

(698) ;. 9

(699) _9_439

(700)

(701)

(702)

(703)

(704)

(705)

(706)

(707)

(708)

(709)

(710)

(711)

(712)

(713)

(714)

(715)

(716)

(717)

(718)

(719)

(720)

(721)

(722)

(723)

(724)

(725)

(726)

(727)

(728)

(729)

(730)

(731)

(732)

(733)

(734)

(735)

(736)

(737)

(738)

(739)

(740)

(741)

(742)

(743)

(744)

(745)

(746)

(747)

(748)

(749)

(750)

(751)

(752)

(753)

(754)

(755)

(756)

(757)

(758)

(759)

(760)

(761)

(762)

(763)

(764)

(765)

(766)

(767)

(768)

(769)

(770)

(771)

(772)

(773)

(774)

(775)

(776)

(777)

(778)

(779)

(780)

(781)

(782)

(783)

(784)

(785)

(786)

(787)

(788)

(789)

(790)

(791)

(792)

(793)

(794)

(795)

(796)

(797)

(798)

(799)

(800) . 7`7a_83

(801)

(802)

(803)

(804)

(805)

(806)

(807)

(808)

(809)

(810)

(811)

(812)

(813)

(814)

(815)

(816)

(817)

(818)

(819)

(820)

(821)

(822)

(823)

(824)

(825)

(826)

(827)

(828)

(829)

(830)

(831)

(832)

(833)

(834)

(835)

(836)

(837)

(838)

(839)

(840)

(841)

(842)

(843)

(844)

(845)

(846)

(847)

(848)

(849)

(850)

(851)

(852)

(853)

(854)

(855)

(856)

(857)

(858)

(859)

(860)

(861)

(862)

(863)

(864)

(865)

(866)

(867)

(868)

(869)

(870)

(871)

(872)

(873)

(874)

(875)

(876)

(877)

(878)

(879)

(880)

(881)

(882)

(883)

(884)

(885)

(886)

(887)

(888)

(889)

(890)

(891)

(892)

(893)

(894)

(895)

(896)

(897)

(898)

(899)

(900) . b9

(901)

(902)

(903)

(904)

(905)

(906)

(907)

(908)

(909)

(910)

(911)

(912)

(913)

(914)

(915)

(916)

(917)

(918)

(919)

(920)

(921)

(922)

(923)

(924)

(925)

(926)

(927)

(928)

(929)

(930)

(931)

(932)

(933)

(934)

(935)

(936)

(937)

(938)

(939)

(940)

(941)

(942)

(943)

(944)

(945)

(946)

(947)

(948)

(949)

(950)

(951)

(952)

(953)

(954)

(955)

(956)

(957)

(958)

(959)

(960)

(961)

(962)

(963)

(964)

(965)

(966)

(967)

(968)

(969)

(970)

(971)

(972)

(973)

(974)

(975)

(976)

(977)

(978)

(979)

(980)

(981)

(982)

(983)

(984)

(985)

(986)

(987)

(988)

(989)

(990)

(991)

(992)

(993)

(994)

(995)

(996)

(997)

(998)

(999)

(1000)

(1001)

(1002)

(1003)

(1004)

(1005)

(1006)

(1007)

(1008)

(1009)

(1010) 9. 2. 012.

(1011) 3. 2. 0112 2. 3. 0112.

(1012) 021112 2. 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 546789 4 6

(1013) 7 4 47887446 77 4. 2. 01112.

(1014) 0123 3. 4. 3. 0123.

(1015) 2012 2. 34536789 7

(1016) . 222!22"#$#2%$$22&''$22'222(2 ')#22)22#22*)+*#)',2 2%&-222*)*22.$22')2/1$2(20*!220',2 22#)'2122)$2%#$$#22222')#22$#322 )+,2 2 2. 2. 012.

(1017) 4 4 4. 0123 3. 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3. 5 5 5 5 5 5 5 5 5 5 5 6 3. 0123.

(1018) 01223 3. 456789 954

(1019) 67 8 69 9 !"#$" %&'()'*+$,-./,+01!"123456" ++2"(+(!2"+&27+0 12#'()'*0%+!2"0##"1!"2 +!,#2%&0 +$,-./,+'''''''''''''''''''''''''''''''''''''''''''''' *5 82"("!01("001210$!0#11'()'3 !"#$1+"#210922"":%"# "1!$' ()'30+,!,#2%"#&+!"'()'32+,!,#2%"$"'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''*; <0$!0#11#"!#2''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''*= > 1!)" 2+2("#"1!"+ )"1+2 "+ $? 12" 1+!#120#!"2%#"!$0 1"(# -. &++""#"+/,@0+2" !"#$' '''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''*A B C!22")+1"!$'3DDD%#07$0,$2++1"(# 2'2%!2'''''''''''''''''''''''''''''''*E F2"("!&++"%#""10G2%#!"02 $"0 #"+/,@0+2" !"#$ %$1!2+"!%#"!'" +"!#101201"(# -.&++"%&+ED2+'" 0+"!H,$1201"(# -.&++"%&+*3D ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''33 2+')#,%!0%I' J0$97#)#,%!0%*3D%&+ 0"#-.'()'=0$97#)#,%!0%I*3D2+%&+ 0"#-.' 2" 1+!#12/,"1.G,9"("0G "1!!!$22"("!%&+*3D2+'''''''''''''''''''''''''''''''''''''''''''''''''33 K" L120 %#"+"1-2", $1G0 "1!1!"+"%#12++ 2,#2"++1"(# 2 )#,%!0%IMD0#!"G+!$&)00#20 !#0N 02" ++1'O"!92"*D:'" +"!%#"!120 #222"("!"+"!9"# "$G120#"+/,@02" !"#$)#,%!0%MD0#2" G"4O"!92" P:''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''3M Q+"!$#)120/,"2,#R7!"#%"# 1"0",1!0!" !2++0#!"+40#2" G"'''''''''''''''''3P S(! 0#)#(2" 1+!#127#"22"("!&++"' 1!)" 2+2("#"1!"+ )"1+2$? 1' )#,%ED2+0#2" !#0N 02" ++1'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''3P (! 0#)#(2" 1+!#121"(# -.&++"$1)22"("!'0#!"G+!$&)00#2 0 !#0N 02" ++1')#,%ED2+' ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''35 8" 11201"(# -.&++"'2120#222"("!'0#!"G+!$&)00#2" G"' ()'*32" 1+!#/,"1.G7%#"+"1-2$1G0 "1!1!"+"%#12++ 2,#2++ 1"(# 2!#112R++12+!1),@9"+'0#!"0#2" !#0N 02" ++1')#,%*3D2+''''''' 35 9 T 9 9 9 9 9 9 9 9 9 9. 3. 01223.

(1020) 012223 3. 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3. 3 012223.

(1021) 0102 2. 3456789 867 3758 8

(1022) !"##$% "&"$"'!"#$"(""')'$!* % +#,$ !'"#$ "'+#-.% +#/,$ !'"#$+##"#"012"/34" "/!!'-***************************************************************************************************************************************05

(1023) 67$8)""'"9$"":*""'9""'"#$"'"%'9#:* *****************************************************************************************************************************************************************;<

(1024) =7$8)""'"9$"": >?1*""'9""'"#$"'" %'9#:@********************************************************************************************************************************************* ;<

(1025) A7$8)""'"9$"": >0;1*'3:"9""' ;B "#$"'"%'9#:@******************************************************************************************************************* 8 8 8 8 8 8. C. 2. C. 0102.

(1026) 001 1. 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 22 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2. 2 1. 001.

(1027) 02012 2. 3456789 854 3758.

(1028) 222122 !"21#01$12#112#2%&12 '( 222)&1#11$&12$2(*1+,2 1&-12 '.!22/1,2#20122.2#2!1/12 12"21/22#2%&12 !22/#2#21#01$122#2 31"2212'1/)&#2#2&412#2/-2 5 '!22&12 1&12#2'0$1/+,2!1/&2 '2212'&2#11#2$2)&22 '6!"271#2'1&#1/112 89!22%1#2201&)/12 '"2/01&1:'122 (812212#21/23/&;22()&12 <1!6&2212)&2&21*#2#2&)&262 <1=2 2212)&2=$$2 2 2"32222 >!<?"2>$2!1*#2#212<)&2=$$2 2 >!<?922912#2>$2#212<)&2=$$2 2 312231&12 6122@212#21/226/+,2 2 6>!12A22>$2#212#2<26)/&2 @2262 21261%&12 B62"2C2121%&12 2 2 D D D D D 2. 0012.

(1029) 01 1. 23456789 6

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

(1031) 01 1. 12134567189

(1032) 11465471151637153176157141437157143541 5514135143541!"141!""1#$%&' (1)41746161543*15+,61134+5141 6144-154.14-71/0161643711543*11571714135141 64/75711575441717634512344)2.10""5(1)314641517461 45173371751737.157371413714107(12177121-461/671 34171751451614464371641411756171+414117.16141 436513-4145417671157451714173473714145417141 164466146117347*1822)1431(.10"!!(1)3714673561 6411973731:22;15443173-41 '<= >&14113,141756171161 413314611457411615016714617717+71671 ?2@ABCD)2.10"!;(1?4-711431534573.17189

(1033) <419737317461 451771145E61514541751157544171417+(11 F4714,737.17154434135/7134-4176717G43-71-51177634.11 414143651147756171+41411734717141617-717634511 4141H1I:F154714189

(1034) <41973731 '<= =&(1 1 1 1 1 1 1 1 J J J J J 1. 101.

(1035) 01 1. 23456789 7 9 4 4

(1036) 11 1!1"#11$%"$&1$'!1"!(1)#($1*"($(11 "+,$(1$#-"-(#1$!$((1!(#./1#"$((10#1'-"-(112(1!(#.1'1$"3(1 0#1!(#(1#),$1!415+#(11-6)$1017/10#)-($110#3$(1$81 -()9$(:110#1!(#(1$#),$15#!(10#$0(-!$10#101155(1 16-1$(15#!(11;#<(0((1=>?>?@/1ABB0:1C72?D2EF@GH/1ABBIJ111 1-6)$101710#0#$(1(1 1-((115-<+-(1110K11 5#!(1#$((1!1(-#$(L811"(1#$(L811(#1!11<11($(-11M(&#1 =FNC2O/1PQQQ:1C72?D2EF@GH/1ABBIJ11@1"$8116-11155#15#!(1#(1 1M#<(0((1R(PB1=SIJT1=MJA/1$1*"11#(10 "!1"!(1(0(11 ;#((L810(#(15(-(#1(1#(113$1$#11#(-11-3*"1$#(-11@1( (L81(1 ;#<(0((1!1(15+#(1-6)$(10#!&1(1#9$(11"#.(10(#(111 1 =UGEVG27?@:1R@?E27?/1PQQQJ11 W$#1(10#3$(1$81-()9$(10#$1$(1!(#.181(1(-$(/1/1(1 $$(11(10$$(1*"181$.((10#1'-"-(1 (1$!$((1 +-(/11()!1$10# 11!$#(-.(L8111 1#)"-($1(1(811 (&(1-"-(#1"#($115$X!$115#!(L811#(+#L81 (1=C72?D2EF@GH/1 ABBIJ11@1(-$(1$'!1!1"(1!-'"-(101#3"1161(#+<)-"(!1Y1Z1 =0#3$(111[\@J/1'1#0$6&-10-(15<(L8116-11(1;#<(0((/1$1"!(1(1 0#3$(1-()$(1!(1(+"$($1$(1!(#.1<#(-"-(#/1(-'!110 "#1+(<101 !-"-(#112"1($##1$(!1"(10(#0(L81$1##"(!$115#$(L81 -6(1=@]\711(-1/1ABB^:1W_?2N:1S@7]@:1R@HS@E@/1ABBPJ111 @1$$(1$81!1"!(15"$L81-(#(!$15$(/1$1$($/1(10#3$(1 $)"11-)(#1(1!-'"-(11-6)$111(810(#0($1$(1#)($.(L81(1 !(#.1<#(-"-(#11@-'!1 /1610#$1$11*"15#!1#!-(L811 !#5)9$1=@EW?@W211(-1/1ABB`:1C72?D2EF@GH/1ABBIJ11@10$$(1$&#1 1. 1 01.

(1037) 01 1. 213456344317389 821

(1038) 56

(1039) 41

(1040) 14