• Nenhum resultado encontrado

Estudos estruturais e funcionais de proteinas da familia SBDS com enfase nas ortologas de Trypanosoma cruzi e humana

N/A
N/A
Protected

Academic year: 2021

Share "Estudos estruturais e funcionais de proteinas da familia SBDS com enfase nas ortologas de Trypanosoma cruzi e humana"

Copied!
115
0
0

Texto

(1)0.

(2) 1 1 1 1 1 1 1 1 1 1 1 1. 2 2 2 2 2 2 2 2 2 1 1 1 1 1 . 1 1. 1. 134567157879

(3) 3457197

(4) 771971 494 8571 148488 114 9 4711457 1 2 111 1 2222222222222222222p+/c4/'*b2f(+/*,*2\4''4/'*2-42. 9qr11111111111111e2&(-02242&'(&('*/2242.(,)/0,*/22-427'0&4[,*22-*2.*8 [+/*2 %56%2)08 2s,.*242,*220'&t+0T*22-42EFGHIJKLKM INOFPQR242 3(8 *,*2l2f(+/*,*2\4''4/'*2-42p+/c4/'*92V2`*8 7/,*2b2%U@2 u29,9vb2jkkn92 22222p'/4,&*-0'42@2_,*2`*'0+/,*2-42] *&&022a4'/b2S/+20,2wc02 x0,/,2a*,)3/,92 22222x4242y-0(&0'*-0z2V2{,/c4'2/-*-42e2&*-(*+2-42222222222222222222222 `*8 7/,*2b2w,2&/&(&02-425/0+0T/*92 2 22222|922U'0&4[,*2%56%922j92B/C02208 022D25/022[,&4249222}922 EFGHIJKLKM INOFPQR9222~922B4220,,)/*28 *T,€&/)*2,()+4*'222 ‚922U'0&4[,*22D2e2&'(&('*9222w922a4'/b2_,*2`*'0+/,*2-42] *&&029222 ww922a*,)3/,b2S/+20,2wc02x0,/,9222www922{,/c4'2/-*-42e2&*-(*+2 -42`*8 7/,*292w,2&/&(&02-425/0+0T/*9222wƒ922x[&(+0922. 1 1 1 11111111111111111 111111111111111111 1 1 2 2 1 y')-&l/Cz 1 1 1 81 1 !"#$1%&'()&('*+2*,-2.(,)&/0,*+2*,*+12/220.2&342%56%27'0&4/,2.*8 /+192 ::;<:#=>?:;1 1 !"#@2%56%27'0&4/,A2B/C0208 422D25/021,&342/2A2EFGHIJKLKM INOFPQRA2 S()+4*'28 *T,4&/)2'420,*,)4A2U'0&4/,22V2%&'()&('492 <:1W1> > <:XY$15/0Z([8 /)*92 8:XY$260(&0'*248 25/0+0T/*2\(,)/0,*+242] 0+4)(+*'922 : >:1^:  :W<:$2_,*2`*'0+/,*2-42] *&&022a4'/b2\*C/02`4,4c/c*2d*)4'-*2_+8 4/-*b2B0,*+-02 _+c422U/,&02S*T48 b2d(/22e-(*'-02%0*'422S4&&0b2fg'T2h0C*'T92 ::1W:1Wi#:@2jklkmljkkn92 <!<: :1W1o#= <:W:XY$15/0+0T/*2\(,)/0,*+242] 0+4)(+*'91. „„.

(5) .

(6) †‡ˆ†‰Š‹Œ ŠŽ‘ ’“”•–—˜™š›“—œ“ž Ÿ˜ ›“¡“¢œ£•¤¥˜“—›“¦¥§˜—›“—œ“¨š›“¢˜•©›ª“”¢¦¨¢ª“Ÿœ©›“˜•«¬©¤› ­¤–˜–®œ¤ ›“®›–®œ—¤—›“˜“œ¥§œ“Ÿ ›¯œ§›° ›“±˜²› ˜§³ ¤›“´˜®¤›–˜©“—œ“±•µ“¨¬–® ›§ ›–ª“±´±¨ª“Ÿœ©˜“¤–­ ˜¶œ¥§ •§• ˜“›­œ œ®¤—˜° ›“´¤©¥›–“·˜–®¸¤–ª“Ÿœ©˜“®›¶› ¤œ–§˜™š›“œ“Ÿœ©˜“›Ÿ› §•–¤—˜—œ“—œ“ œ˜©¤µ˜ “œ¥§œ“Ÿ ›¯œ§› —œ“—›•§› ˜—›° ’“¹œ˜§ ¤µ“º •¤ž ˜ šœ¥ª“¥œž Ÿ œ“ž •¤§›“Ÿ˜®¤œ–§œª“¥›©¬®¤§˜“œ“˜§œ–®¤›¥˜ª“Ÿœ©˜“¥•˜ › ¤œ–§˜™š›° ’“–˜“»˜ ›©¤–˜“·œ ¤ª“Ÿ› “ž œ“˜®œ¤§˜ “®›ž ›“˜©•–˜“–›“—œ®›  œ “—›“—›•§› ˜—›“œ“Ÿœ©˜ Ÿ˜®¤¼–®¤˜“œ“› ¤œ–§˜™š›° ›“½ ˜• ¤®¤›“¨­› ™˜ª“Ÿœ©˜“®›¶› ¤œ–§˜™š›“œž “¾½ ´°“¿ ˜—œ™›“¥•˜“Ÿ˜®¤¼–®¤˜“œ“§›—›¥“›¥ ¥œ•¥“œ–¥¤–˜ž œ–§›¥° ›¥“¢ ›­¥°“½ ˜ ®›“À ¤œ¿œ “œ“¹œ˜§ ¤µ“»˜¥§¤©¸›ª“Ÿ› “ž œ“ œ®œ²œ œž “œž “¥œ•¥ ©˜²› ˜§³ ¤›¥ª“Ÿœ©˜“˜§œ–™š›“œ“—¤¥Ÿ›–¤²¤©¤—˜—œ° ›¥“Ÿœ¥£•¤¥˜—› œ¥“—›“Á¹½ ¢“»¸ ¤¥§¤˜–“¢ ›²¥§ª“˜–¤œ©˜“¢˜Ã›–¤“œ“©œ¯˜–— ›“»›  œ˜“œ“˜ §›—›¥“›¥“˜©•–›¥“£•œ“ž œ“˜•«¤©¤˜ ˜ž “—• ˜–§œ“ž œ•¥“Äœ¥§Å¿¤›¥Æ“–›“Á¹½ ¢° ’¥“¢ ›­˜¥°“»˜ ©˜“Ç ©¤Ãœ¤ ˜“œ“ȸ˜ ¤–“¹©•ž œ–¥®¸œ¤–ª“Ÿœ©˜“®›©˜²› ˜™š›“–œ¥¥œ“Ÿ ›¯œ§›ª Ÿœ©˜¥“¥•¿œ¥§Éœ¥“œ“® ¬§¤®˜¥“›­œ œ®¤—˜¥° ›¥“¢ ›­¥°“Ê› ¿“À›²˜ ¿ª“»©˜•—¤›“Ë œ –œ®Ì“œ“½ ˜ ¤›“½ • ˜Ì˜ž ¤ª“Ÿœ©˜“Ÿ˜ §¤®¤Ÿ˜™š›“–› œ«˜ž œ“—œ“£•˜©¤­¤®˜™š›“œ“˜Ã˜©¤˜™š›“—œ¥§œ“§ ˜²˜©¸›° ›¥“ž œž ² ›¥“—˜“²˜–®˜“¶“¢ ›­¥°“”˜²¤›“©ž œ¤—˜ª“¾›–˜©—›“´˜¿œž ª“±•¤¥“¦—•˜ —›“´œ§§› œ“Ê› ¿“À›²˜ ¿“¶“Ÿœ©˜“—¤¥Ÿ›¥¤™š›“œž “Ÿ˜ §¤®¤Ÿ˜ “—˜“˜Ã˜©¤˜™š›“­¤–˜©“—œ¥§œ“§ ˜²˜©¸›° ›“Ÿ ›¿ ˜ž ˜“—œ“¢³¥¶¿ ˜—•˜™š›“œž “¹¤›©›¿¤˜“”•–®¤›–˜©“œ“½ ›©œ®•©˜ “—˜“Í´Á»½ ¢° ÎÏ.

(7) ÐÑÒÓÔÕÒÖ×ØÒÙÚÑÛÕÒÜÓÝ×ÞßØÑÞàÛØÑÒÓÕÓÙá×ÞÑÒÓÚÑÓâãâäÜÓÔÕáÑÓÒ×ÔÑÛåÕÓåæßÞØßÑÜ ßÑÞçØçèÞßØÙÓÕÓåÛÑßÙÓÚÕÓÕéÔÕÛØèÞßØÙÒê ÐÑÒÓÙë ØìÑÒÓÚÑÓìÛ×ÔÑÓâíî ÜÓÔÑÛÓåÕÛÕë Óë ÕÓÛÕßÕïØÚÑÓë ×ØåÑÓïÕë ÓÕÓÔÕáÑÒÓÕÞÒØÞÙë ÕÞåÑÒð íØÙÜÓñÕÚÛØßÜÓñÕáØÒÙÜÓòáÙçØÙÜÓó×ÜÓâÕÙÞÚÛÑÜÓôÙåØÜÓõÑë ÕÞØÙÜÓäÙÞÚÛÙÓÕÓö÷ÙØÒê ÐÑÒÓÙë ØìÑÒÓÚÑÓìÛ×ÔÑÓÚÕÓßÛØÒåÙáÑìÛÙÝØÙÜÓÔÕáÙÓøåØë ÙÓßÑÞçØçèÞßØÙðÓÐë ÙÞÚÙÜÓñÙë ØáÙÜ ñÙÛáÙÜÓñÙÛÑáÜÓòÙïØÑÜÓùÙÛÕÞÜÓùÕááúÜÓî ÙÛßÑÒÜÓî ÙÛØÑÜÓãÙÚØÙÜÓôÛØÜÓöÙåØÜÓûÙÞÕÒÒÙê ÐÑÒÓÞÑçÑÒÓÙë ØìÑÒÓÚÑÓìÛ×ÔÑÓÚÕÓõî ãðÓÐáÕéÙÞÚÛÕÜÓñÙë ØáÙÜÓòÙïØÑÓÕÓóÑÛìÕê ÐÑÒÓÙë ØìÑÒÓÚÑÓñÕíØî üÜÓÔÕáÙÓåÛÑßÙÓÚÕÓÕéÔÕÛØèÞßØÙÜÓÒ×ìÕÒåýÕÒÓÕÓßÛþåØßÙÒðÓÐáØÞÕÜÓÐÞÙ ÿ áþçØÙÜÓÐÞÚÛæÜÓÐÞÚÛæÒÜÓ0ÙÞØÕáÓî öÜÓ0ÙÞØÕáÓâÙÞ1ÙÜÓü×ìÕÞØÙÜÓ2 ×ìÙÜÓ2 ×ÒåÙçÑÜÓó×áØÑÜ âÕåØßØÙÜÓâ×áØÜÓî ÙÛßÑÒÜÓî ÙÛìÙÛÕå÷ÜÓî ÙÛØÞÙÜÓãÙåúÜÓõÕÞÙåÙÜÓõÑÒØÜÓöØÙìÑÜÓûÕÛ×Ò3Ùê 4ÒÓÖ×ÕÛØÚÙÓÙë ØìÙÒÓÐÚÛØÙÞÙÜÓÐÞÚÛÕØÙÜÓñÕáØÒÙÜÓüáÙØÞÕÜÓ2 ØçÙÞØáÜÓöÕÛÕ1ÙÜÓÕÓ5ØáÚÕÞÕÜÓÔÕáÑ Ù×éþáØÑÓÔÛàåØßÑÓÕÓåÕøÛØßÑÜÓÒ×ìÕÒåýÕÒÓÕÓßÛþåØßÙÒÓÕÓÔÕáÙÓøåØë ÙÓßÑÞçØçèÞßØÙêÓÐìÛÙÚÕ6ÑÓÔÑÛ ÒÕÛÕë ÓÒÕë ÔÛÕÓë ×ØåÑÓÒÑáþßØåÙÒê ÐÑÒÓë Õ×ÒÓÖ×ÕÛØÚÑÒÓÙë ØìÑÒÓÖ×þë ØßÑÒÓÐáÕÒÒÙÞÚÛÙÜÓÐë ÙÚÕ×ÜÓ7ÕáÚÕÛÓÕÓäÙë ÙÞåÙê ÐÑÓë Õ×ÓßÑë ÔÙÞ÷ÕØÛÑÓÕÓÒÕë ÔÛÕÓÙë ØìÑÓòÙïØÑêÓÐìÛÙÚÕ6ÑÓÔÑÛÓÕÒåÙÛÓÒÕë ÔÛÕÓÙÑÓë Õ× áÙÚÑÜÓÞ8ÑÓë ÕÓÔÕÛë ØåØÞÚÑÓÚÕÒØÒåØÛÓÕë Óë Ñë ÕÞåÑÓÙáì×ë ê 4Óë ØÞ÷ÙÓÝÙë þáØÙÜÓÖ×ÕÓÒÕë ÔÛÕÓë ÕÓÙÔÑØÑ×ÓÕÓØÞßÕÞåØçÑ×Óë ×ØåÑêÓôÛØÞßØÔÙáë ÕÞåÕÓÙÑÒ ë Õ×ÒÓÔÙØÒÜÓÔÑÛÓë ÕÓÔÙÒÒÙÛÕë ÓÑÒÓçÙáÑÛÕÒÓÞÕßÕÒÒàÛØÑÒÓÔÙÛÙÓÕ×Óß÷ÕìÙÛÓÙåæÓÙÖ×Øê ôÑÛÓÝØë ÜÓÙìÛÙÚÕ6ÑÓÙÓ0Õ×ÒÓÔÑÛÓå×ÚÑê. 9.

(8)

(9)   

(10)    

(11)     

(12)     ! "   # "$ "

(13) %" $ &'&'()*+,,-./0,0(10(2*3+,,+4 +,''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''& &'5'(67/+20,(0.8+98*1+,(.7(3*+,,-./0,0(10(2*3+,,+4 +,'''''''''''''''''''''''''''''''''''''''''''5 &':'(;(1+0.<7(=>=(0(7(?2+/0-.7(=)>='''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''@ &'A'(B3C0/*8+,''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''&5 # "D

(14) " 

(15) #" 

(16) !  

(17)  $E 5'&'(F 7/02*7*,(0(F G/+1+,'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''&H 5'&'&'(I+.,/2J<K+(1+,(80/+20,(10(0L?20,,K+''''''''''''''''''''''''''''''''''''''''''''''''''''&H 5'&'5'(ML?20,,K+(17,(?2+/0-.7,'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''&@ 5'&':'(NJ2*O*P7<K+(17,(?2+/0-.7,(0(204 +<K+(17(P7J17(10(Q*,/*1*.7 '''''''''''''''''''&R 5'&'A'(I2+4 7/+S27O*7(10(0LP9J,K+(4 +90PJ972(7.79-/*P7'''''''''''''''''''''''''''''''''''''''&T 5'&'H'(N2+/0U9*,0(9*4 */717'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''&V 5'&'@'(M.,7*+(?727(7.W9*,0(10(7S20S7<K+''''''''''''''''''''''''''''''''''''''''''''''''''''''''''&V 5'&'R'(;.W9*,0,(10(>*P2+-,4 +(I*2PJ972(XI>Y'''''''''''''''''''''''''''''''''''''''''''''''''''''''5Z 5'&'T'(M.,7*+,(10(P2*,/79*[7<K+''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''5& 5'&'V'(ML?02*4 0./+,(10(\0,,+.].P*7(F 7S.G/*P7(^JP9072(X\F ^Y''''''''''''''''''''''55 5'5'(\0,J9/71+,'''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''5@ 5'5'&'(=)>=(10(_`abcbccdefgh`eeij(N7kN6ZZ5:''''''''''''''''''''''''''''''''''''''''''''''5@ 5'5'5'(=)>=(10(lgccmgabn `coefcoaopieigoj(qr\Z55P''''''''''''''''''''''''''''''''''''''5V 5'5':'(=)>=(10(sa`tgubebn gfcadvij(wP=)>=''''''''''''''''''''''''''''''''''''''''''''''''''':& 5'5'A'(=)>=(10(xbn bfegtiouej(y,=)>='''''''''''''''''''''''''''''''''''''''''''''''''''''''''':: 5':'(>*,PJ,,K+ ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''HZ # " z {   " 

(18) #"  

(19) 

(20) |}~€‚ƒ‚„ € †}‡ˆ‰Š‹

(21) Œ‚„ ‚ ƒ€‰ŽƒŠ

(22) Œ‘z. ’“.

(23) ”ê•êÓÐõö–2 ÿ ӖӗÓñ÷ÙÛÙßåÕÛØ1ÙåØÑÞÓÑÝÓå÷ÕÓöÛúÔÙÞÑÒÑë ÙÓßÛ×1ØÓÑÛå÷ÑáÑìÓÑÝÓå÷ÕÓäí0ä ÔÛÑåÕØÞÓÛÕçÕÙáÒÓÙÞÓØÞåÛØÞÒØßÙááúÓÚØÒÑÛÚÕÛÕÚÓÕéåÕÞÚÕÚÓñ—åÕÛë ØÞÙáÓÛÕìØÑÞÓÒ÷јØÞì õãЗØÞåÕÛÙßåØÞìÓÙßåØçØåúêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꙚ ”ê›êÓÐõö–2 ÿ Ӗ–Ó—ÓäåÛ×ßå×ÛÕÜÓÚúÞÙë ØßÒÓÙÞÚÓõãÐÓØÞåÕÛÙßåØÑÞÓÙÞÙáúÒØÒÓÑÝÓå÷ÕÓ÷×ë ÙÞ äí0äÓÔÛÑåÕØÞêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꜚ žŸ ¡¢£¤¥¦§¥¤¨£¢©ª«©¥«¥Ÿ«¬©Ÿ«¡­®ž© §§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§¯° ¬«±«¬²¨­ž©¥³­³£­¤´¬µ±­ž© §§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§§¯¶. ·¸¸.

(24) £­©¡ž¥¹«¥¡ž³«£ž© öÙïÕáÙӕê•ðÓî ×åÙ6ýÕÒÓÞÑÓìÕÞÕÓº»¼ºÓÛÕáÙßØÑÞÙÚÙÒÓ½ÓÚÑÕÞ6ÙÓä0ä êêêêêêêêêêêêêêêêêêêêêêêêꕕ öÙïÕáÙӛê•ðÓÿáØìÑÞ×ßáÕÑåþÚÕÑÒÓ×åØáØ1ÙÚÑÒÓÔÙÛÙÓÔÛÑÚ×68ÑÓÚÑÒÓßáÑÞÕÒÓÚÕÓÕéÔÛÕÒÒ8Ñ êꕙ öÙïÕáÙӛê›ðÓõÕìØ8ÑÓßÑÛÛÕÒÔÑÞÚÕÞåÕÓ½ÒÓÚØÝÕÛÕÞåÕÒÓßÑÞÒåÛ×6ýÕÒÓÚÙÓ7Òäí0äêêêêêêêêêêêꕜ öÙïÕáÙӛê”ðÓÐÚØåØçÑÒÓ×åØáØ1ÙÚÑÒÓÞÙÓåÕÞåÙåØçÙÓÚÕÓÚØë ØÞ×ØÛÓÙÓÙìÛÕìÙ68ÑÓÚÙÓÔÛÑåÕþÞÙ ößäí0äÓåÛ×ÞßÙÚÙêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꕾ öÙïÕáÙӛêšðÓöÙë ÔýÕÒÓÕÓßÑÞßÕÞåÛÙ6ýÕÒÓ×åØáØ1ÙÚÑÒÓÞÙÒÓë ÕÚØÚÙÒÓÚÕÓñ0 êêêêêêêêêêêêêêêêêêê꛿ öÙïÕáÙӛê™ðÓ0ÕÒßÛØ68ÑÓÚÑÒÓÕÞÒÙØÑÒÓÚÕÓßÛØÒåÙáØ1Ù68ÑÓÛÕÙáØ1ÙÚÑÒÓßÑë ÓÙÒÓÚØÝÕÛÕÞåÕÒ ÔÛÑåÕþÞÙÒêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꛕ öÙïÕáÙӛêœðÓ0ÕÒßÛØ68ÑÓÚÙÒÓÙë ÑÒåÛÙÒÓÚÙÓ7Òäí0äÓ×åØáØ1ÙÚÙÒÓÔÙÛÙÓÑÒÓÕéÔÕÛØë ÕÞåÑÒÓÚÕ õî ã êêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꛔ öÙïÕáÙӛêÀðÓÐÞàáØÒÕÓÚÙÓößäí0äÓåÛ×ÞßÙÚÙÓÕë ÓÚØÝÕÛÕÞåÕÒÓÔ7ÒÓÔÑÛÓÕéÔÕÛØë ÕÞåÑÒÓÚÕ 0âäÓÕÓÕÒÔÕßåÛÑÒßÑÔØÙÓÚÕÓÙïÒÑÛ68ÑÓÚÕÓá×1Ó×áåÛÙçØÑáÕåÙêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꔛ. ÁÂÂÂ.

(25) £­©¡ž¥¹«¥±­´¢¬ž© òØì×ÛÙӕê•ðÓüÒÖ×Õë ÙÓÚÑÓÔÛÑßÕÒÒÙë ÕÞåÑÓÚÑÓÔÛæ—ÛõãÐÓÕë ÓºÃÄÄÅÃÆÇÈ ÉÄÊË ÄÊÆÊÌÍËÍÃÊÎ Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î êêêêêêêêêêêêêêêêêêêêêêê” òØì×ÛÙӕê›ðÓõÕÔÛÕÒÕÞåÙ68ÑÓÚÕÓÙáì×ÞÒÓÚÑÒÓÝÙåÑÛÕÒÓÕÞçÑáçØÚÑÒÓÞÑÓÔÛÑßÕÒÒÑÓÚÕ ë Ùå×ÛÙ68ÑÓÕÓÕéÔÑÛåÙ68ÑÓÚÙÒÓÒ×ï×ÞØÚÙÚÕÒÓÛØïÑÒÒÑë ÙØÒӚ¿äÓÕӜ¿äÎ Î Î Î Î Î êêêêêêš òØì×ÛÙÓ •ê”ðÓ ÐáØÞ÷Ùë ÕÞåÑÓ ÚÙÒÓ ÒÕÖ×èÞßØÙÒÓ ÚÕÓ Ùë ØÞÑàßØÚÑÒÓ ÚÕÓ ë Õë ïÛÑÒ ÛÕÔÛÕÒÕÞåÙåØçÑÒÓÚÙÓÝÙë þáØÙÓäí0äêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêÏ òØì×ÛÙӕêšðÓüÒåÛ×å×ÛÙÓÚÙÓÔÛÑåÕþÞÙÓäí0äÓÚÕÓÐÆÄÅÃÊÇÑÒÇÓÔËÕÖÔÒÑÍ×ÔËÓØÐÝäí0äÙÚÚÚÚÚÚÚÚÚÚÚ¾ òØì×ÛÙӛê•ðÓÐÞàáØÒÕÒÓÚÕÓÚØßÛÑþÒë ÑÓßØÛß×áÙÛÓÚÙÓôÙÛôò¿¿›”Î Î Î Î Î Î Î Î Î Î êêê›À òØì×ÛÙӛê›ðÓñÛØÒåÙØÒÓÚÙÓÔÛÑåÕþÞÙÓôÙÛôò¿¿›”Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î êêê›À òØì×ÛÙӛê”ðÓô×ÛØÝØßÙ68ÑÓÕÓÕÞÒÙØÑÒÓÚÕÓßÛØÒåÙáØ1Ù68ÑÓÚÙÓÜâõ¿››ßêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꔿ òØì×ÛÙӛêšðÓÐÞàáØÒÕÒÓÚÕÓÚØßÛÑþÒë ÑÓßØÛß×áÙÛÓÚÙÓÜâõ¿››ßêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꔿ òØì×ÛÙӛê™ðÓô×ÛØÝØßÙ68ÑÓÚÙÓÔÛÑåÕþÞÙÓößäí0äÓåÛ×ÞßÙÚÙêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꔛ òØì×ÛÙӛêœðÓô×ÛØÝØßÙ68ÑÓÚÙÓÔÛÑåÕþÞÙÓäí0äÓ÷×ë ÙÞÙêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꔚ òØì×ÛÙÓ ›êÀðÓ ñÛÑë ÙåÑìÛÙÝØÙÓ ÚÕÓ Õéßá×Ò8ÑÓ ë ÑáÕß×áÙÛÓ ÙÞÙáþåØßÙÓ ÚÙÓ ÔÛÑåÕþÞÙ 7Òäí0äêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꔙ òØì×ÛÙӛêÏðÓÐÞàáØÒÕÒÓÚÕÓÚØßÛÑþÒë ÑÓßØÛß×áÙÛÓÚÙÓ7Òäí0äÓÎ Î Î Î Î Î Î Î êêêêêêêêêêêêêꔙ òØì×ÛÙӛê¾ðÓî ØßÛїßÛØÒåÙØÒÓÑïåØÚÑÒÓÚ×ÛÙÞåÕÓÕÞÒÙØÑÒÓÚÕÓßÛØÒåÙáØ1Ù68ÑÓßÑë ÓÙÓÔÛÑåÕþÞÙ äí0äÓ÷×ë ÙÞÙÓÎ Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î êêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꔜ òØì×ÛÙӛꕿðÓôÛÑåÕøáØÒÕÓáØë ØåÙÚÙÓÚÙÓ7Òäí0äÓÎ Î Î Î Î Î Î Î Î Î Î Î Î Î Î Î êê”À òØì×ÛÙӛꕕðÓüÒÔÕßåÛÑÓÚÕÓë ÙÒÒÙÓÚÙÓ7Òäí0äÓÙÔøÒÓÔÛÑåÕøáØÒÕÓáØë ØåÙÚÙÓßÑë ÓåÛØÔÒØÞÙ ”À òØì×ÛÙӛꕛðÓô×ÛØÝØßÙ68ÑÓÚÑÒÓÚÑë þÞØÑÒÓÚÙÓ7Òäí0ä êêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêê”Ï òØì×ÛÙӛꕔðӖá×ÒåÛÙ68ÑÓÚÑÒÓÕéÔÕÛØë ÕÞåÑÒÓÚÕÓåÛØÔáÙÓÛÕÒÒÑÞÝÞßØÙÓßÑáÕåÙÚÑÒÓÔÙÛÙÓÑ ÙÒÒØÞÙáÙë ÕÞåÑÓÒÕÖ×ÕÞßØÙáÓÚÙÓÔÛÑåÕþÞÙÓ7Òäí0ä êêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꚿ òØì×ÛÙӛꕚðÓÐÒÒØÞÙáÙë ÕÞåÑÓÒÕÖ×ÕÞßØÙáÓÚÙÓÔÛÑåÕþÞÙÓ7Òäí0äÓ×åØáØ1ÙÞÚїÒÕÓÑ ÔÛÑìÛÙë ÙÓäë ÙÛåÞÑåÕïÑÑ3êêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꚛ òØì×ÛÙӛꕙðÓñ÷Õë ØßÙáÓä÷ØÝåӖÞÚÕéÓØñä–ÙÓÔÙÛÙÓÑÒÓàåÑë ÑÒÓñÞÓÚÙÓÔÛÑåÕþÞÙÓ7Òäí0äêꚔ òØì×ÛÙӛꕜðӖá×ÒåÛÙ68ÑÓÚÙÓåÛÙÞÒÝÕÛèÞßØÙÓÚÕÓë ÙìÞÕåØ1Ù68ÑÓÕÞçÑáçØÚÙÓÞÑÓÕéÔÕÛØë ÕÞåÑ ÚÕÓ7ññ7—öÿñäÜêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꚚ òØì×ÛÙӛê•ÀðÓÐÒÒØÞÙáÙë ÕÞåÑÓÚÙÓßÙÚÕØÙÓáÙåÕÛÙáÓÚÑÓÙë ØÞÑàßØÚÑÓØÒÑáÕ×ßØÞÙӕ¿ÓÚÙ 7Òäí0ä êêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêꚙ òØì×ÛÙӛê•ÏðÓüéÔÕÛØë ÕÞåÑÒÓÚÕÓåÛÑßÙÓ÷ØÚÛÑìèÞØÑßÚÕ×åæÛØÑÓØ7ß0ÙÓÚÙÓ7Òäí0äêêêêêêêêêêêêêšÀ àá.

(26) òØì×ÛÙӛꕾðÓãÿüÒÓßÙÛÙßåÕÛþÒåØßÑÒÓÚÕÓÕÒåÛ×å×ÛÙÒÓÒÕß×ÞÚàÛØÙÒêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêêšÏ òØì×ÛÙӛ꛿ðÓüåÙÔÙÒÓÚÑÓßàáß×áÑÓÚÙÓÕÒåÛ×å×ÛÙÓÚÙÓÔÛÑåÕþÞÙÓ7Òäí0ä êêêêêêêêêêêêêêêêêêêêêêêêêêꚾ. â.

(27) £­©¡ž¥¹«¥ž³¬«®­žãª«© ”äüöä ™äüöä ÐÝäí0ä íî õí ñ—åÕÛë ØÞÙá ñ0 ß0ãÐ ñ77 ñãä ñÿäÜ ñÜÐãÐ. 0íÐ 0ñ 0âä 0ãÐ 0öö 0ÜÐãÐ üî äÐ òÜä7 7ä0ñ 7Òäí0ä –ôö2 –öä• –öä› âí. üÒÔÙ6ÙÚÑÛÓÕéåÕÛÞÑӔäÓØåæçÊÆèÃÒÕéÆÃèËÄÆÍÓÊ×ÕºêÃÄÊÆÕëìí üÒÔÙ6ÙÚÑÛÓÕéåÕÛÞÑәäÓØåæçÊÆèÃÒÕéÆÃèËÄÆÍÓÊ×ÕºêÃÄÊÆÕëìí ôÛÑåÕþÞÙÓäí0äÓÚÕÓÐÆÄÅÃÊÇÑÒÇÓÔËÕÖÔÒÑÍ×ÔË íÙÞßÑÓÚÕÓÚÙÚÑÒÓÚÕÓõî ãÓØ»ÍÇÒÇÑÍÄÃÒÕî ÃÑèÊçÍÄÕïÊËÇèÃèÄÊÕ¼ÃçÃÕ»ÃèðÙ üéåÛÕë ØÚÙÚÕÓßÙÛïÑéØÓåÕÛë ØÞÙáÓÚÙÓÔÛÑåÕþÞÙ 0ØßÛÑþÒë ÑÓßØÛß×áÙÛÓØñÍÆÄÔÒÃÆÕ¼ÍÄÅÆÇÍËÈ Ù 0ãÐÓßÑë ÔáÕë ÕÞåÙÛ 7ØÔÑÔáÙÒØÙÓßÙÛåØáÙìÕë —ßÙïÕáÑÓØñÃÆçÍÒÃÑÊòóÃÍÆÕóÉêÇêÒÃËÍÃÙ ôÛÑìÛÙë ÙÓßÑë Ô×åÙßØÑÞÙáÓÔÙÛÙÓÚÕåÕÛë ØÞÙ68ÑÓÕÒåÛ×å×ÛÙáÓÙÓÔÙÛåØÛÓÚÕ ÚÙÚÑÒÓÚÕÓßÛØÒåÙáÑìÛÙÝØÙÓÕÓõî ãÓØñÆÉËçÃÒÒÇÑÆÃêÅÉÕôÕõî ïÕºÉËçÊÈ Ù üÒÔÕßåÛÑÒßÑÔØÙÓÚÕÓßÑÛÛÕáÙ68ÑÓ÷Ñë ÑÞ×ßáÕÙÛ ØñöÆÆÊÒÃçÍÇèÕºêÊÄçÆÇËÄÇê÷Ù ôÛÑìÛÙë ÙÓßÑë Ô×åÙßØÑÞÙáÓÔÙÛÙÓßàáß×áÑÓÒÕë ؗÙ×åÑë ÙåØ1ÙÚÑÓÚÕÓÕÒåÛ×å×ÛÙ ÚÕÓÔÛÑåÕþÞÙÒÓÔÑÛÓõî ã ØñÇÈ ÓÍèÊ×ÕÃËËÍÑèÈ ÊèçÕÃè×Õ×÷èÃÈ ÍÄËÕÐÒÑÇÆÍçÅÈ ÕÖÇÆÕõî ïÕÐêêÒÍÄÃçÍÇèËÙ ÐÞÕë ØÙÓ0ØÙë ÑÞڗíáÙß3ÝÙÞÓؼÍÃÈ Çè×ò»ÒÃÄðÖÃèÕÐèÊÈ ÍÃÙ 0ØÒÖ×ÕÛÙåÑÒÕÓßÑÞìèÞØåÙÓؼÉËðÊÆÃçÇËÍËÕñÇèÑÊèÍçÃÙ üÒÔÙá÷Ùë ÕÞåÑÓÚØÞÝë ØßÑÓÚÕÓá×1ÓؼÉèÃÈ ÍÄÕøÍÑÅçÕºÄÃççÊÆÍèÑÙ ùßØÚÑÓÚÕÒÑéØÛØïÑÞ×ßáÕØßÑÓؼÊÇæÉÆÍÓÇèÔÄÒÊÍÄÕÐÄÍ×Ù •Üš—ÚØåØÑåÛÕØåÑá ôÛÑìÛÙë ÙÓßÑë Ô×åÙßØÑÞÙáÓÔÙÛÙÓßàáß×áÑÓÚÕÓÕÒåÛ×å×ÛÙÓÚÕÓÔÛÑåÕþÞÙÒÓÔÑÛ õî ãÓؼ÷èÃÈ ÍÄËÕÐÒÑÇÆÍçÅÈ ÕÖÇÆÕõî ïÕÐêêÒÍÄÃçÍÇèËÙ üÞÒÙØÑÓÚÕÓØÞåÕÛÙ68ÑÓÔÛÑåÕþÞٗõãÐÓØåÒÊÄçÆÇêÅÇÆÊçÍÄÕÈ ÇÓÍÒÍçÉÕËÅÍÖçÕÃËËÃÉÙ 0Ñë þÞØÑÓã—åÕÛë ØÞÙáÓÚÙÓäí0äÓØúÔèÑÃÒûÕ÷ÅÆüýþÿêûÕºÅÿÃÄÅÈ ÃèÙ üÒÔÕßåÛÑÒßÑÔØÙÓÚÕÓßÑÛÛÕáÙ68ÑÓ÷ÕåÕÛÑÞ×ßáÕÙÛ ØóÊçÊÆÇèÔÄÒÊÃÆÕºÍèÑÒÊÕ1ÔÃèçÔÈ ÕñÇÅÊÆÊèÄÊÙ ôÛÑåÕþÞÙÓäí0äÓÚÕÓóÇÈ ÇÕËÃêÍÊèË –ÒÑÔÛÑÔØáÓ2—3—•—åØÑìÙáÙßåÑÔØÛÙÞÑÒþÚÕÑ üÒÔÙ6ÙÚÑÛÓØÞåÕÛÞÑӕÓØÍèçÊÆèÃÒÕçÆÃèËÄÆÍÓÊ×ÕËêÃÄÊÆÕ4Ù üÒÔÙ6ÙÚÑÛÓØÞåÕÛÞÑӛÓØÍèçÊÆèÃÒÕçÆÃèËÄÆÍÓÊ×ÕËêÃÄÊÆÕ5Ù î ÕØÑÓÚÕÓß×áå×ÛÙÓÚÕÓïÙßåæÛØÙÒÓ6â×ÛØÙÓíÕÛåÙÞØ7 89.

(28) ë õãÐ ë å÷äí0ä ãÿü ãÿüäÜ. õãÐÓë ÕÞÒÙìÕØÛÑ ôÛÑåÕþÞÙÓäí0äÓÚÕÓî ÊçÅÃèÇçÅÊÆÈ ÇÓÃÄçÊÆÕçÅÊÆÈ ÃÔçÇçÆÇêÅÍÄÔË üÝÕØåÑÓã×ßáÕÙÛÓÿçÕÛ÷Ù×ÒÕÛÓØõÔÄÒÊÃÆÕöÌÊÆÅÃÔËÊÆÕåÖÖÊÄçÙ üÒÔÕßåÛÑÒßÑÔØÙÓÚÑÓüÝÕØåÑÓã×ßáÕÙÛÓÿçÕÛ÷Ù×ÒÕÛ ØõÔÄÒÊÃÆÕöÌÊÆÅÃÔËÊÆÕåÖÖÊÄçÕºêÊÄçÆÇËÄÇê÷Ù ã—åÕÛë ØÞÙá üéåÛÕë ØÚÙÚÕÓÙë ØÞÑÓåÕÛë ØÞÙáÓÚÙÓÔÛÑåÕþÞÙ ÿ0 œ¿¿ 0ÕÞÒØÚÙÚÕÓøåØßÙÓÙӜ¿¿ÓÞÙÞ ë ÕåÛÑÒ ôÙÛôò¿¿›” ôÛÑåÕþÞÙÓäí0äÓÚÕÓ ÉÆÇÄÇÄÄÔËÕÃÓÉËËÍ ôñõ õÕÙ68ÑÓÕë ÓßÙÚÕØÙÓÚÙÓÔÑáØë ÕÛÙÒÕÓØ ÇÒÉÈ ÊÆÃËÊÕñÅÃÍèÕïÊÃÄçÍÇèÙ ô0í íÙÞßÑÓÚÕÓÚÙÚÑÒÓÚÕÓÕÒåÛ×å×ÛÙÓÚÕÓÔÛÑåÕþÞÙÒÓØ ÆÇçÊÍèÕ¼ÃçÃÕ»ÃèðÙ Ô7 ôÑåÕÞßØÙáÓ÷ØÚÛÑìÕÞØ ÞØßÑ ôî äò òá×ÑÛÕåÑÓÚÕÓÝÕÞØáë ÕåØáÒ×áÝÑÞØáÙ õî ã õÕÒÒÑÞÝÞßØÙÓî ÙìÞæåØßÙÓã×ßáÕÙÛÓØõÔÄÒÊÃÆÕî ÃÑèÊçÍÄÕïÊËÇèÃèÄÊûÕõî ïÙ õãÐ ùßØÚÑÓõØïÑÞ×ßáÕØßÑÓØõÍÓÇèÔÄÒÊÍÄÕÐÄÍ×Ù õãÐÒÕô õØïÑÞ×ßáÕÙÒÕÓô õãô õØïÑÞ×ßáÕÑÔÛÑåÕþÞÙ õõî 0Ñë þÞØÑÓÚÕÓÛÕßÑÞ÷ÕßØë ÕÞåÑÓÙÑÓõãÐÓØïõÐÕïÊÄÇÑèÍçÍÇèÕî ÇçÍÖÙ ÛõãÐ õãÐÓÛØïÑÒÒÑë Ùá äí0ä ôÛÑåÕþÞÙÓÙÒÒÑßØÙÚÙÓ½ÓÒþÞÚÛÑë ÕÓä÷˜Ùß÷ë ÙޗíÑÚØÙޗ0ØÙë ÑÞÚ ØºÅÿÃÄÅÈ Ãèò»Ç×ÍÃèò¼ÍÃÈ Çè×ÕºÉè×ÆÇÈ ÊÙ º»¼º 2ÕÞÕÓÖ×ÕÓßÑÚØÝØßÙÓÙÓÔÛÑåÕþÞÙÓäí0ä º»¼º ôÒÕ×ÚÑìÕÞÕÓÚÕÓº»¼º º×Ç4ê ôÛÑåÕþÞÙÓäí0äÓÚÕÕºÃÄÄÅÃÆÇÈ ÉÄÊËÕÄÊÆÊÌÍËÍÃÊ ä0ä äþÞÚÛÑë ÕÓä÷˜Ùß÷ë Ùޗ0ØÙë ÑÞÚÓغÅÿÃÄÅÈ Ãèò¼ÍÃÈ Çè×ÕºÉè×ÆÇÈ ÊÙ ä0ä—ôÐ2ü üáÕåÛÑÝÑÛÕÒÕÓÕë ÓìÕáÓÚÕÓÔÑáØÙßÛØáÙë ØÚÙÓßÑë ÓÚÑÚÕßØáÓÒ×áÝÙåÑÓÚÕÓÒøÚØÑ ÒÞÑõãÐ ôÕÖ×ÕÞÑÓõãÐÓÞ×ßáÕÑáÙÛÓØËÈ ÃÒÒÕèÔÄÒÊÇÒÃÆÕïõÐÙ ÒÞÑõãô ôÕÖ×ÕÞÙÓÔÙÛåþß×áÙÓÛØïÑÞ×ßáÕÑÔÛÑåæØßÙÓÞ×ßáÕÑáÙÛ ØËÈ ÃÒÒÕèÔÄÒÊÇÒÃÆÕÆÍÓÇèÔÄÒÊÇêÆÇçÊÍèÙ ößäí0ä ôÛÑåÕþÞÙÓäí0äÓÚÕÓéÆÉêÃèÇËÇÈ ÃÕÄÆÔ

(29) Í öñöô ôÛÑåÕþÞÙÓÙÒÒÑßØÙÚÙÓÙÓå×ë ÑÛÜÓÛÕì×áÙÚÙÓÕë ÓÞþçÕáÓÚÕÓåÛÙÚ×68Ñ ØçÆÃèËÒÃçÍÇèÃÒÒÉÕÄÇèçÆÇÒÒÊ×ÕçÔÈ ÇÆòÃËËÇÄÍÃçÊ×ÕêÆÇçÊÍèÙ öüû ôÛÑåÕÙÒÕÓÚÑÓçþÛ×ÒÓÚÑÓåÙïÙßÑÓØéÇÓÃÄÄÇÕåçÄÅÕ ÍÆÔËÕêÆÇçÊÃËÊÙ öë öÕë ÔÕÛÙå×ÛÙÓë æÚØÙÓÚÕÓåÛÙÞÒØ68Ñ .

(30) öÿñäÜ åõãÐ Üâõ¿››ß. üÒÔÕßåÛÑÒßÑÔØÙÓÚÕÓßÑÛÛÕáÙ68ÑÓ÷Ñë ÑÞ×ßáÕÙÛÓåÑåÙá ØéöçÃÒÕñÇÆÆÊÒÃçÍÇèÕºêÊÄçÆÇËÄÇê÷ õãÐÓåÛÙÞÒÔÑÛåÙÚÑÛ ôÛÑåÕþÞÙÓäí0äÓÚÕÓºÃÄÄÅÃÆÇÈ ÉÄÊËÕÄÊÆÊÌÍËÍÃÊ. .

Referências

Documentos relacionados

Não é nossa intenção abordar aqui todos os tipos de processos estocásticos exis- tentes, mas sim analisar, com algum detalhe, uma pequena parcela, bastante relevante para o estudo

Confirming the pathogenicity of isolates B1, 9P, 10P, and 12P, only leaves of coffee seedlings inoculated with the respective suspensions reproduced the symptoms of

Nesse sentido, podemos destacar que a passagem família-escola pode ser entendida como uma cena, um encontro, em que algo – a criança, o enigma, o desejo, o infantil sexual - passa de

O objetivo deste estudo foi testar a consorciação da couve-de-folhas, cultura principal, com outras hortaliças folhosas alface e cebolinha, sob dois manejos com biofertilizante antes

pratica diaria da cultura physica. ft1turo de nossa 11acionalidade. todos os nossos alumnos, praticada melhores dias. systematicamente durante todo o pe- Entre estas

Como os cristais líquidos são estados físicos intermediários ao estado sólido e ao estado líquido, é dito que apresentam uma ou mais mesofases entre esses dois estados..

Deste modo, foi feita uma análise da ocorrência dos diferentes tipos de sinais emitidos pelos golfinhos na presença e na ausência de embarcações e uma análise

Esses achados destacam a importância da avaliação de fatores que podem representar variáveis relevantes para obtenção de resultados positivos após a cirurgia