Biosynthetic pathway
Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression
... The capability of tumors to reprogram cellular metabolism and promote uncontrolled proliferation has only recently emerged as a cancer hallmark (Hanahan & Weinberg, 2011; Cairns, Harris & Mak, 2011; Dang, 2012). ...
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De novo transcriptome assembly and the putative biosynthetic pathway of steroidal sapogenins of Dioscorea composita.
... Steroidal sapogenins are complex molecules and are synthesized by equally complex biosyn- thetic pathways. As there is no genetic information about D. composita, it is very difficult to re- veal the biosynthesis of the ...
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Molecular and Biochemical Analysis of Chalcone Synthase from Freesia hybrid in flavonoid biosynthetic pathway.
... The biosynthetic pathway of flavonoid has been extensively investigated in different model and economically important plant species, such as potato [44], grape [45] and apple ...flavonoid pathway, ...
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Evolution of the vitamin C biosynthetic pathway and transport mechanism: from the global perspective to a Drosophila melanogaster case study
... the pathway, such as Regucalcin, affect many metabolic traits when absent (in the example given, caprolactam degradation, and the pentose phosphate pathway, among others) (Moreno et ...
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Arctic mustard flower color polymorphism controlled by petal-specific downregulation at the threshold of the anthocyanin biosynthetic pathway.
... Intra- and interspecific variation in flower color is a hallmark of angiosperm diversity. The evolutionary forces underlying the variety of flower colors can be nearly as diverse as the colors themselves. In addition to ...
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Nucleotide diversity of a major carotenoid biosynthetic pathway gene in wild and cultivated Solanum (Section Lycopersicon) species
... carotenoid biosynthetic pathway is one of the most extensively known in plants with an array of structural genes and gene products already characterized (Cunningham and Gantt, 1998; Isaacson et ...
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Evolutionary origins and functions of the carotenoid biosynthetic pathway in marine diatoms
... carotenoid pathway compo- nents is shown in Table 1, and details concerning the early carotenoid biosynthetic pathway are given in the Supplementary ...
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The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission.
... GSH biosynthetic pathway in the rodent malaria Plasmodium berghei by disrupting the pbggcs ...GSH biosynthetic pathway, while essential for mosquito stage development, is not an appropriate ...
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The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence
... common biosynthetic pathway for all ...biosynthesis pathway can increase three to eight times the yeast cells are subjected to pyrim- idine limitation (Roy et ...
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Genetic variants in the MicroRNA biosynthetic pathway Gemin3 and Gemin4 are associated with a risk of cancer: a meta-analysis
... In the biogenesis of miRNAs, the Argonaute proteins (Ago1-4) along with Gemin3 and Gemin4 selectively bind to the guide strand to facilitate the formation of an miRNA- RNA-induced silencing complex (RISC) (Slaby et al., ...
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Genetic, biocheminal, and biophysical studies of the heme biosynthetic pathway.
... a pathway have been isolated as multifunctional enzyme complexes ...glycolytic pathway [1], pentose phosphate pathway ...a pathway, and are thus called metabolons ...the pathway ...
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Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc : ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth
... the biosynthetic machinery for GlcCer expression appears to be universally distributed among fungi [1,8,10,21,24] (and references cited ...the biosynthetic functions of the ...
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Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc: ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth (vol 525, pg 59, 2002)
... c Department of Biochemistry, Universidade Federal de Sa‹o Paulo/Escola Paulista de Medicina, Rua Botucatu 862, 04023-900 Sa‹o Paulo SP, Brazil d Division of Nephrology, Department of In[r] ...
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Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
... genes, we newly constructed full deletion mutants, Degt1 and Degt2, by replacing the target loci in the WT h 2 972 strain with the kanamycin resistance marker (kanMX). Correct integration of the kanMX modules into the ...
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Genome-scale transcriptome analysis in response to nitric oxide in birch cells: implications of the triterpene biosynthetic pathway.
... In the group of genes linked to growth regulation, we found nine genes to be repressed and eight genes to be enhanced. The expression of gibberellin 2-beta- dioxygenase 2 (G2OX2), nitrate reductase (NR) and NO associated ...
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Investigation of the biosynthetic potential of endophytes in traditional Chinese anticancer herbs.
... In an attempt to investigate the homology and novelty of amplicons from the genetic screen, the deduced amino acid sequence of the KS and A domain gene fragments were used in multiple sequence alignments and the ...
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Biosynthetic origins of the isoprene units of 4-nerolidylcatechol in Potomorphe umbellata
... triose/pyruvate pathway is compartmentalised in the plastids of plant cells and is involved in the formation of mono-, di-, and tetra- terpenoids, whilst the MVA pathway is located in the cytoplasm and is ...
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Analysis of occludin trafficking, demonstrating continuous endocytosis, degradation, recycling and biosynthetic secretory trafficking.
... Tight junctions (TJs) link adjacent cells and are critical for maintenance of apical- basolateral polarity in epithelial monolayers. The TJ protein occludin functions in disparate processes, including wound healing and ...
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A novel approach for the characterisation of proteoglycans and biosynthetic enzymes in a snail model
... as the type of inter- and intradisaccharide glycosydic linkages. Sulphated GAGs are ubiquitous to the animal kingdom of the Eukarya domain, whereas in the bacteria kingdom only non-sulphated chains of GAGs are found. ...
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Biosynthetic origin of the isoprene units in chromenes of Piper aduncum (Piperaceae)
... confirm that the initial prenylation of the p- hydroxybenzoic acid precursor of chromenes 1 and 2 occurred via MEP pathway (Figure 1). The aromatic and methoxyl carbons enrichments might be due to complex ...
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