Factor H
The interaction between factor H and Von Willebrand factor.
... We compared the binding of recombinant VWF-A2 and VWF-A1 to full-length and truncated fH molecules, using a co- immunoprecipitation assay. After incubation with fH molecules, the recombinant VWF-A2 domain (GST-A2 fusion ...
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Employer Branding: Uma Estratégia de Atração e Retenção de Talento aplicada à empresa Factor H
... a Factor H uma empresa de consultoria que presta serviços na área do recrutamento, do desenvolvimento pessoal e da formação, existe a possibilidade de apresentar a utilização da estratégia do EB aos seus ...
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Human factor H-related protein 2 (CFHR2) regulates complement activation.
... and factor H bind to C3b (Figure 3) and inhibit C3 convertase activities we assayed how the combination of the two proteins modulates complement ...and factor H, each used at concentration ...
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Alterations of choroidal blood flow regulation in young healthy subjects with complement factor H polymorphism.
... A common polymorphism in the complement factor H gene (rs1061170, Y402H) is associated with a high risk of age-related macular degeneration (AMD). In the present study we hypothesized that healthy young ...
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Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3.
... The major human complement regulator in blood, complement factor H (FH), has several closely related proteins, called FH-related (FHR) proteins. As all FHRs lack relevant comple- ment regulatory activity, ...
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Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration.
... We also analyzed the HTRA1 rs 11200638 polymorphism (Table S2). LOC387715 rs10490924 and HTRA1 rs11200638 are located only 6.1 kb from each other, and correspondingly, we observed only 5 genotypes out of 787 that were ...
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Meningococcal factor H binding proteins in epidemic strains from Africa: implications for vaccine development.
... A number of protein antigens are being developed for prevention of meningococcal serogroup B disease (Reviewed in [23,24]). These antigens also are prevalent in meningococcal strains with other capsular serogroups ...
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Thrombotic Microangiopathy with Complement Factor H Gene Mutations Unassociated with Atypical Hemolytic Uremic Syndrome
... Atypical hemolytic uremic syndrome (aHUS) is a rare multigenic disorder characterized by thrombotic microangiopathy (TMA). Among the genes that are associated with aHUS, mutations in the complement factor H ...
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Interaction of complement factor h and fibulin3 in age-related macular degeneration.
... Age-related macular degeneration (AMD) is a major cause of vision loss. It is associated with development of characteristic plaque-like deposits (soft drusen) in Bruch’s membrane basal to the retinal pigment epithelium ...
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Microbes bind complement inhibitor factor H via a common site.
... Complement is an important arm of innate immunity. Activation of this plasma protein cascade leads to opsonization of targets for phagocytosis, direct lysis of Gram-negative bacteria, and enhancement of the inflam- ...
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Affinity purification of human factor H on polypeptides derived from streptococcal m protein: enrichment of the Y402 variant.
... Factor H (FH) plays a key role in the regulation of complement activation, both in the fluid phase and on cell surfaces [1-3]. This ~150 kDa glycoprotein, which is composed of 20 short consensus repeats ...
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Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.
... regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the chromosome 1q32 locus linked to SLE, have been associated with multiple human diseases and may contribute to dysregulated ...
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Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi.
... for factor I- mediated degradation of C3b and support the dissociation (decay- accelerating activity) of the C3 convertase, C3bBb ...‘‘factor H-related’’ proteins (CFHR1, CFHR2, CFHR3, CFHR4A, ...
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The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement.
... Complement forms an important arm of innate immunity against invasive meningococcal infections. Binding of the alternative complement pathway inhibitor factor H (fH) to fH-binding protein (fHbp) is one ...
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The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.
... Sbi:C3d:Factor H complexes represent –to our knowledge- a novel mechanism for Factor H ...attachment. Factor H has a C3b/C3d binding region within the C-terminal recognition region, ...
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Arq. Bras. Oftalmol. vol.72 número4
... Most of the AMD-associated CFH SNPs lie within important functional domains of the encoded protein. These domains con- tain binding sites for C3b, heparin, sialic acid, and C-reactive protein. Thus, these SNPs might ...
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An overview on the treatment for atypical hemolytic uremic syndrome
... ESRD: end-stage renal disease; MCP: membrane cofactor protein; DGKɛ: diacylglycerol kinase ɛ; FH: Factor H; CFH: complement factor H; CFI: complement factor I; CFB[r] ...
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An analysis of the sequence variability of meningococcal fHbp, NadA and NHBA over a 50-year period in the Netherlands.
... PorA [16,17,18,19] have been used: though, those vaccines only provide protection for homologous strains carrying the same PorA [20–23]. To overcome antigenic variability, vaccines based on multiple outer membrane ...
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Temporal Changes in BEXSERO® Antigen Sequence Type Associated with Genetic Lineages of Neisseria meningitidis over a 15-Year Period in Western Australia.
... Neisseria meningitidis (the meningococcus) is the causative agent of invasive meningococcal disease (IMD). IMD is characterised by meningitis and/or fatal septicaemia. The highest inci- dence of IMD occurs in infants ...
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Rev. bras.oftalmol. vol.71 número3
... complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degen- eration in the Finnish ...tor H gene and neovascular age-related ...
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