Neutralizing Antibodies
B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies.
... of neutralizing antibodies during infection and is also a component in several experimental HCMV vaccines currently being tested in ...gB-specific antibodies secreted from B-cell clones do not have ...
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Genome-wide association study on the development of cross-reactive neutralizing antibodies in HIV-1 infected individuals.
... increase neutralizing antibodies in the absence of CD4 ab T cells against vesicular stomatitis virus (VSV), foot-and-mouth disease virus, as well as Borrelia burgdorferi, the causative agent for lyme ...
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Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection.
... non-neutralizing antibodies induced by H7 vaccination in humans could provide protection through the same ...highly neutralizing mAbs 1A8 and 1B2 in mice at the doses tested was com- parable to the ...
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Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.
... The coronaviruses (CoVs) are enveloped viruses of animals and humans associated mostly with enteric and respiratory diseases, such as the severe acute respiratory syndrome and 10–20% of all common colds. A subset of CoVs ...
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Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.
... broadly neutralizing, including the monoclonal antibodies 2F5 and 4E10 [40,41] and Z13e1 ...specific neutralizing antibodies are only rarely found in HIV-1 infected subjects [90,91] and ...
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Synthetic B-Cell Epitopes Eliciting Cross-Neutralizing Antibodies: Strategies for Future Dengue Vaccine.
... Neutralizing antibodies at suboptimal concentrations or pre-existing cross-reactive antibod- ies in dengue patients are hypothesized to enhance the severity of subsequent DENV infection through the ...
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Pichia pastoris-expressed dengue 2 envelope forms virus-like particles without pre-membrane protein and induces high titer neutralizing antibodies.
... titer neutralizing antibodies, using both epithelial and Fc receptor-bearing cell substrates and capable of conferring partial protection against lethal DENV-2 challenge in a mouse ...VLP-induced ...
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Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults
... virus neutralizing antibodies in previously vaccinated persons aged ≥ 60 years, in comparison to younger ...virus neutralizing antibody titers were determined by means of the 50% Plaque Reduction ...
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Comparison of two high-throughput assays for quantification of adenovirus type 5 neutralizing antibodies in a population of donors in China.
... Ad5 neutralizing antibodies should be focused ...key neutralizing epitopes on the surface of viral capsid proteins, such as Ad5/35 fiber chimeras and Ad5/48 hexon chimeras ...
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Co-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8+ T cells.
... autologous neutralizing antibodies specific for V3 in six ...These neutralizing antibodies were sustained for 16 weeks without boosting, and comparable responses were obtained when ...
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Hepatitis C Virus E1 and E2 Proteins Used as Separate Immunogens Induce Neutralizing Antibodies with Additive Properties.
... non-neutralizing antibodies [41, ...for neutralizing antibody induc- tion: (i) E1 displays a higher degree of intergenotype cross-reactivity than E2, which varies con- siderably between strains, ...
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In vivo emergence of HIV-1 highly sensitive to neutralizing antibodies.
... monoclonal antibodies IgG1b12, 2G12 and ...contemporaneous neutralizing antibodies during ...autologous neutralizing antibodies are present in patient ...
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HIV-1 binding and neutralizing antibodies of injecting drug users
... of neutralizing antibodies from the V3 and V2 loop of HIV-1 gp120, from the genotypes/ variants A, B, Bbr, C, D, E, F, and Brazilian Fbr, and against the HIV-1 MN gp41 amino acids 735-752 (735) and 669-674 ...
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Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA.
... The membrane-proximal external region (MPER), located within the gp41ectodomain, is one of the most conserved regions on Env. It contains epitopes of three well-characterized human bNmAbs: 2F5, 4E10, and 10E8 [11– 16]. ...
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Interplay between basic residues of hepatitis C virus glycoprotein E2 with viral receptors, neutralizing antibodies and lipoproteins.
... with E2-specific antibodies. Three mutants (H617A, R657A and R659A) were not immunoprecipitated by this method suggesting that significant conformational changes are associated with the alanine mutations. These ...
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Correlation between dengue-specific neutralizing antibodies and serum avidity in primary and secondary dengue virus 3 natural infections in humans.
... with IgG serum avidity to DENV3. Because of the rapid kinetics of appearance of IgG Abs in a 2 u DENV infection and the slow affinity maturation process, these highly avid IgG Abs are most likely secreted by MBCs formed ...
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Report of the First Brazilian Symposium on Basic Research in HIV AIDS
... to neutralizing antibodies and cytotoxic T lymphocytes (CTL), therefore these immune re- sponses are attempted to be induced by anti-HIV/ AIDS vaccine ...autologous neutralizing antibodies, ...
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Virulence in Murine Model Shows the Existence of Two Distinct Populations of Brazilian Vaccinia virus Strains
... of neutralizing antibodies point to the development of a sub-clinical infection in mice after inoculation of GP2V, ARAV, PSTV and the control strain LST-BUT by intranasal ...
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Functional screen of paracrine signals in breast carcinoma fibroblasts.
... with neutralizing antibodies as described for ...blocking antibodies to FGF- 2, HB-EGF, heparanase-1, MT1-MMP, SDF-1 and TGF-b1 significantly diminished carcinoma cell growth stimulation ...
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