6- DISCUSSÃO
7.0 CONCLUSÃO
Concluindo, os resultados apresentados neste projeto sugerem que o tratamento com células tronco reduz a dor neuropática diabética através da modulação das citocinas pró-inflamatórias e anti-inflamatórias.
Pela primeira vez demonstramos a interação de células tronco com receptores P2X4 que são ativados pelo ATP endógeno no GRD.
Demonstramos, também pela primeira vez, um dos efeitos parácrinos das células tronco através da ativação dos seus receptores P2X4 na liberação de grande quantidade de BDNF.
Neste trabalho pudemos observar que os efeitos analgésicos das células tronco se dão independentemente do processo de regeneração das fibras nervosas periféricas.
Mecanismos de controle anti-inflamatórios endógenos e o receptor P2X4 tornam-se possíveis alvos farmacológicos de interesse para o desenvolvimento de novos medicamentos que atuem no controle da hiperalgesia neuropática diabética, de maneira mais precisa e objetiva, a fim de reduzir os efeitos colaterais dos pacientes em tratamento.
Estes dados, até o momento, também sugerem fortemente que o uso de CTM administradas no espaço subaracnóideo (intratecal) é uma terapia viável para o controle da dor neuropática diabética, uma vez que não há disponível no mercado drogas ou outras terapias eficientes.
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