Os resultados sugerem que a introdução do radical nitrofenilamino na posição 3 do anel furano (composto 2) aumenta a citotoxicidade da nor-β-lapachona (composto 1) contra células HL-60 em aproximadamente seis vezes, no entanto, essa aumento da citotoxicidade vem acompanhado pela perda parcial da seletividade para células tumorais. O composto 2 induz morte celular por apoptose, além de aumentar os níveis de espécies reativas de oxigênio. Esses achados apontam para o potencial de quinonas sintéticas como protótipo para a produção de novos compostos com propriedades anticâncer.
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