A incorporação de clorexidina em materiais de base de prótese tem-se mostrado um procedimento interessante, uma vez que o agente antimicrobiano permanece no local de ação e é necessária menor concentração do agente para obter o efeito terapêutico desejado na estomatite protética. A preparação em pó parece ser mais favorável nos condicionadores de tecidos e nos liners pela sua eficácia e exequibilidade; nas resinas acrílicas, a incorporação por imersão apresenta bons resultados na duração de libertação (28 dias), bem como na eficácia e ainda permite que seja novamente recarregada. Contudo, as propriedades das resinas tendem a ser mais afetadas com a incorporação de clorexidina do que os outros materiais estudados.
A comparação entre estudos é difícil de realizar uma vez que são aplicadas diferentes metodologias (formulação, concentração, tempo de incorporação e libertação, avaliação da eficácia), e os materiais têm matrizes diversas com implicações importantes tanto na cinética de libertação da clorexidina como ao nível das suas propriedades.
São necessários mais estudos in vitro padronizados de forma a prever qual o tipo e a formulação de clorexidina mais indicados para cada material (plastificantes e poliméricos) e testar as alterações “incorporadas” nas propriedades físicas e mecânicas de cada um. Preferencialmente, através de métodos com elevada sensibilidade e reprodutibilidade, a incorporação, a libertação e a eficácia da clorexidina incorporada devem ser quantificadas, assim como a possibilidade de recarregamento deve ser testada.
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Anexos
Anexo 1 – Declaração de Autoria da Monografia
Anexo 2 – Parecer do Orientador para entrega definitiva do trabalho apresentado