Houve melhoras nos parâmetros clínicos periodontais ao longo dos 12 meses da pesquisa tanto nos pacientes com e sem diabetes, porém sem alterações nos níveis glicêmicos dos pacientes com diabetes. Portanto, a terapia periodontal, nestes pacientes, está indicada por
razões de saúde bucal e não, necessariamente, com a intenção de melhorar o controle glicêmico.
REFERÊNCIAS
AINAMO, J.; BAY, I. Problems and proposals for recording gingivitis and plaque. Int. Dent. J., v. 25, n. 4, p. 229-35, 1975.
ALLEN, E. M. et al. Oxidative and inflammatory status in type 2 diabetes patients with periodontitis. J. Clinical Periodontol., v. 38, n. 10, p. 894-901, 2011.
ALMEIDA, F.; NAVARRO, A.; BASCONES, A. Clinical and Metabolic Changes After Conventional Treatment of Type 2 Diabetic Patients With Chronic Periodontitis. J Periodotol, v. 77, n. 4, p. 591-8, 2006
AMERICAN DIABETES ASSOCIATION (ADA). Classification and Diagnosis of Diabetes.
Diabetes Care, v. 38, p. S8-S16, 2015. Suplemento 1.
ARNETZ, L.; EKBERG, N. R.; ALVARSSON, M. Sex differences in type 2 diabetes: focus on disease course and outcomes. Diabetes Metab. Syndr. Obes., v. 7, p. 409-20, 2014.
BASCONES-MARTINEZ, A. et al. Host defence mechanisms against bacterial aggression in periodontal disease: basic mechanisms. Med. Oral, Patol. Oral Cir. Bucal, v. 14, n. 12, p. e680–5, 2009.
BASCONES-MARTINEZ, A. et al. Periodontal disease and diabetes-Review of the Literature. Med. Oral Patol. Oral Cir. Bucal, v. 16, n. 6, p.e722-9, 2011.
BORGNAKKE, W. S. et al. Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence. J. Periodontol., v. 84, p. S135-52, 2013. Suplemento 4.
BORGNAKKE, W. S. et al. The multi-center randomized controlled trial (RCT) published by the journal of the American Medical Association (JAMA) on the effect of periodontal therapy on glycated hemoglobin (HbA1c) has fundamental problems. J. Evid. Based Dent. Pract., v. 14, n. 3, p. 127-32, 2014.
CASARIN, R. C. V. et al. Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis. J. Periodont., v. 48, n. 1, p. 30–6, 2013.
CHEN, L. et al. Effects of non-surgical periodontal treatment on clinical response, serum inflammatory parameters, and metabolic control in patients with type 2 diabetes: a randomized study. J. Periodontol., v. 83, n. 4, p. 435-43, 2012.
COHEN, D. W.; ROSE, L. F.; MINSK, L. The periodontal-medic risk relationship. Compend. Contin. Educ. Dent., v.19, n.1, p. 11-24, 1998.
CORBELLA, S.; FRANCETTI, L.; TASCHIERI, S.; DE SIENA, F.; DEL FABBRO, M. Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta-analysis. Journal of Diabetes Investigation, v. 4, n. 5, 2013.
COX, J. F.; ZARB, G. A. The longitudinal clinical efficacy of osseointegrated dental implants: a 3-year report. Int. J. Oral Maxillofac. Implants, v. 2, n. 2, p. 91–100, 1987. CRUZ, G. A. et al. Clinical and laboratory evaluations of non-surgical periodontal treatment in subjects with diabetes mellitus. J. Periodontol., v. 79, n. 7, p. 1150-7, 2008.
DEMMER, R. T. et al. The influence of anti-infective periodontal treatment on C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. PLoS One, v.8, n.10, e77441, 2013.
DESHMUKH, J.; JAWALI, M. A.; KULKARNI, V. K. Modulation Therapy – a promising new concept in treating periodontal diseases. Int. J. Dent. Clin., v. 3, n. 2, p. 48-53, 2011. DESHPANDE, K. et al. Diabetes and periodontitis. J. Indian Soc. Periodontol., v. 14, n. 4, p. 207-2012, 2010.
DOGAN, B. et al. Consistent intrafamilial transmission of Actinobacillus
actinomycetemcomitans despite clonal diversity. J. Periodontol., v. 79, n. 2, p. 307–15, 2008.
ENGEBRETSON, S.; KOCHER, T. Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis. J. Clin. Periodontol., v. 40,p. S153–S63, 2013. Suplemento 14.
ENGEBRETSON, S. P. et al. The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. JAMA, v. 310, n. 23, p. 2523-32, 2013.
ESPOSITO, K. et al. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA, v. 292, n. 12, p. 1440-6, 2004.
FERNANDEZ-REAL, J. M.; RICART, W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev, v. 24, p. 278-301, 2003.
GROSSI, S. G.; GENCO, R. J. Periodontal disease and diabetes mellitus: a two-way relationship. Ann. Periodontol., v. 3, n. 1, p. 51-61, 1998.
HANES, P. J.; KRISHNA, R. Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible? EPMA J., v. 1, n. 1, p. 101-16, 2010.
HASEEB, M. et al. Periodontal disease in type 2 diabetes mellitus. J. Coll. Physicians Surg. Pak., v. 22, n. 8, p. 514-518, 2012.
HUANG, D. M. et al. Colonization relationship between Porphyromonas gingivalis and
Bacteroides forsythus in the infected root canals with chronic apical periodontitis. Shanghai
Kou Qiang Yi Xue, v. 14, n. 5, p. 531-535, 2005.
IMRAN, S. A. et al. Targets for glycemic control. Can. J. Diabetes, v. 37, p. S31-34, 2013. Supplement 1.
IWASAKI, M. et al. Longitudinal relationship between metabolic syndrome and periodontal disease among Japanese adults aged ≥70 years: the Niigata Study. J. Periodontol., v. 86, n. 4, p. 491-498, 2015.
IZUORA, K. et al. Impact of periodontal disease on outcomes in diabetes. Contemp. Clin. Trials, v. 41, p. 93-99, 2015.
JANKET, S. J. Scaling and root-planing (SRP) may improve glycemic control and lipid profile in patients with chronic periodontitis (CP) and type 2 diabetes (DM2) in a specific subgroup: a meta-analysis of randomized clinical trials. J. Evid. Based Dent. Pract., v. 14, n. 1, p. 31-33, 2014.
JAVED, F. et al. Effect of nonsurgical periodontal therapy (with or without oral doxycycline delivery) on glycemic status and clinical periodontal parameters in patients with prediabetes: a short-term longitudinal randomized case-control study. Clin. Oral Investig., v. 18, n. 8, p. 1963-8, 2014.
KARJALAINEN, K. M.; KNUUTTILA, M. L. E. The Onset of diabetes and poor metabolic control increases gingival bleeding in children and adolescents with insulindependent diabetes
mellitus. J. Clin. Periodontol., v. 23, p. 1060-1067, 1996.
KOSHY, G.; KAWASHIMA, Y.; KIJI, M.; NITTA, H.; UMEDA, M.; NAGASAWA, T.; ISHIKAWA, I. Effects of single-visit full-mouth ultrasonic debridement versus quadrant-wise ultrasonic debridement. J Clin Periodontol., v. 32, p. 734–743, 2005.
KOU, Y.; INABA, H.; KATO, T. et al. Inflmmatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols. J. Periodontol., v. 79, n. 1, p. 174-180, 2008.
KUDVA, P.; TABASUM, S. T.; GARG, N. Evaluation of clinical and metabolic changes after non-surgical periodontal treatment of type 2 diabetes mellitus patients: a clinic biochemical study. J. Indian Soc. Periodontol., v. 14, n. 4, p.257-62, 2010.
LAKSCHEVITZ, F. et al. Diabetes and periodontal diseases: interplay and links. Curr. Diabetes Rev., v. 7, n. 6, p. 433-439, 2011.
LYRA, R. et al. Prevenção do diabetes mellitus tipo 2. Arq, Bras. Endocrinol. Metabol., v. 50, n. 2, p. 239-249, 2006.
LLAMBES, F. et al. Effect of non-surgical periodontal treatment with or without doxycycline on the periodontium of type 1 diabetic patients J. Clin. Periodontol., v. 32, n. 8, p. 915-920, 2005.
LOE, H. Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care, v. 16, p. 329-334, 1993.
LOPEZ, J. M.; BAILEY, R. A.; RUPNOW, M. F.; ANNUNZIATA, K. Characterization of type 2 diabetes mellitus burden by age and ethnic groups based on a nationwide survey. Clin. Ther., v. 36, n. 4, p. 494-506, 2014.
LOPEZ, N. J; SMITH, P. C.; GUTIERREZ, J. Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease: a randomized controlled trial. J. Periodontol., v. 73, n. 8, p. 911-924, 2002.
LOVEGROVE, J. M. Dental plaque revisited: bacteria associated with periodontal disease. J.
N. Z. Soc. Periodontol., n. 87, p. 7-21, 2004.
MEALEY, B. L.; OATES, T. W. Diabetes mellitus and periodontal diseases. J. Periodontol., v. 77, n. 8, p. 1289-1303, 2006.
MEIGS, J. B. et al. The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging. Diabetes, v. 52, n. 6, p. 1475-1484, 2003.
MENG, H. Association between periodontitis and diabetes mellitus. Beijing Da Xue Xue
Bao, v. 39, n. 1, p. 18-20, 2007.
MOEINTAGHAVI, A. et al. Non-surgical periodontal therapy affects metabolic control in diabetics: a randomized controlled clinical trial. Aust. Dent. J., v. 57, n. 1, p. 31-37, 2012. MUHLEMAN, H. R.; SON, S. Gingival sulcus bleeding- a leading symptom in initial gingivitis. Helvetica Odontologica Acta, v. 15, n. 2, p. 107-113, 1971.
NATALI, A. et al. Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes. Diabetes, v. 55, n. 4, p.1133-1140, 2006.
NISHIMURA, F. et al. Periodontal disease as part of the insulin resistance syndrome in diabetic patients. J. Int. Acad. Periodontol., v. 7, n. 1, p. 16-20, 2005.
ODETTI, P. et al. Good glycaemic control reduces oxidation and glycation end-products in collagen of diabetic rats. Diabetologia, v. 39, n. 12, p.1440-1447, 1996.
OLIVER, R. C.; TERVONEN, T. Diabetes: a risk factor for periodontitis in adults? J. Periodont., v. 65, p. 530-538, 1994. Supplement 5.
PASTER, B. J. Bacterial diversity in human subgengival plaque. J. Bacteriol., v. 183, n. 12, p. 3770- 3783, 2001.
PATEL, S. P. et al. Association of metabolic syndrome and periodontal disease in an Indian population. J. Int. Acad. Periodontol., v. 16, n. 4, p. 98-102, 2014.
PETERSEN, P. E.; OGAWA, H. Strengthening the prevention of periodontal disease: the WHO approach. J. Periodontol., v. 76, n. 12, p. 2187-93, 2005.
QUIRYNEN, M. et al. Full-vs. partial-mouth disinfection in the treatment of periodontal infections: short-term clinical and microbiological observations. J. Dent. Res., v. 74, n. 8, p. 1459-1467, 1995.
RAMAN, R.P.C.; TAIYEB-ALI, T.B.; CHAN, S.P.; CHINNA, K.; VAITHILINGAM, R.D.
Effect of nonsurgical periodontal therapy verses oral hygiene instructions on Type 2 diabetes subjects with chronic periodontitis: a randomised clinical trial. BMC Oral Health, v.14, 2014.
SAITO, Y. et al. Stimulation of Fusobacterium nucleatum biofim formation by Porphyromonas gingivalis. Oral Microbiol. Immunol., v. 23, n. 1, p. 1-6, 2008
SANTOS, V. R. et al. Effectiveness of full-mouth and partial-mouth scaling and root planing in treating chronic periodontitis in subjects with type 2 diabetes. J. Periodontol., v. 80, n. 8, p. 1237-1245, 2009.
SANTOS, V.R.; LIMA, J.A.; MIRANDA, T.S.; GONÇALVES, T.E.D.; FIGUEIREDO, L.C.; FAVERI, M.; DUARTE, P.M. Full-mouth disinfection as a therapeutic protocol for type-2 diabetic subjects with chronic periodontitis: twelve-month clinical outcomes. A randomized controlled clinical trial. J Clin Periodontol, v. 40, p. 155–162, 2013.
SCHMIDT, A. M. et al. Activation of receptor for advanced glycation end products. A mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis.
Circ. Res., v. 84, n. 5, p. 489-497, 1999.
SOCRANSKY, S. S. et al. Effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. I. Overall effect and kinetics of change. J. Clin. Periodontol., v. 40, n. 8, p. 771-780, 2013.
SOSKOLNE, W. A.; KLINGER, A. The relationship between periodontal disease and diabetes: an overview. Ann. Periodontol., v. 6, n. 1, p. 91-98, 2001.
STANKOA, P.; HOLLA, L. I. Bidirectional association between diabetes mellitus and inflammatory periodontal disease. A review. Biomed. Pap. Med. Fac. Univ. Palacky
Olomouc Czech Repub., v. 158, n. 1, p. 35-38, 2014.
STEGEMAN, C. A. Oral manifestations of diabetes. Home Healthc. Nurse, v. 23, n. 4, p. 233-242, 2005.
TANABE, S.; BODET, C.; GRENIER, D. Peptostreptococcus micros cell wall elicits a pro- inflammatory response in human macrophages. J. Endotoxin Res., v. 13, n. 4, p. 219-226, 2007.
TAYLOR, J. J.; PRESHAW, P. M.; LALLA, E. A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J. Periodontol., v. 84, p. S113-S34, 2013. Supplement 4.
TEEUW, W. J.; GERDES, V. E.; LOOS, B. G. Effect of Periodontal Treatment on Glycemic Control of Diabetic Patients. Diabetes Care, v. 33, n. 2, p.421-427, 2010.
TSAI, C.; HAYES, C.; TAYLOR, G. W. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Commun. Dent. Oral Epidemiol., v. 30, n. 3, p. 182-92, 2002.
TSUTSUMI, C.; KAKUMA, T. Regular tooth brushing is associated with a decreased risk of metabolic syndrome according to a medical check-up database. Kurume Med J, 2015.
TURK, Z. et al. Rat tissue collagen modified by advanced glycation: Correlation with duration of diabetes and glycemic control. Clin. Chem. Lab. Med., v. 37, n. 8, p. 813-820, 1999.
TZE-FANG, W.; I-AN, J.; CHYUAN, C.; YEN-PING, L.Effects of Periodontal Therapy on Metabolic Control in Patients With Type 2 Diabetes Mellitus and Periodontal Disease A Me ta-Analysis. Medicine, v. 93, n. 28, p.292, 2014
WANG, T. F. et al. Effects of periodontal therapy on metabolic control in patients with type 2 diabetes mellitus and periodontal disease a me ta-analysis. Medicine (Baltimore), v. 93, n. 28, p. e292, 2014.
WORLD HEALTH ORGANIZATION. Global health estimates: deaths by cause, age, sex and country, 2000-2012. Geneva: WHO, 2014.
YETKIN, A. Z. et al. The impact of the IL11: IL17 ratio on the chronic periodontitis pathogenesis: a preliminary report. Oral diseases, v. 15, n. 1, p. 93-99, 2009.
ZHOU, M. et al. Investigation of the Effect of Type 2 Diabetes Mellitus on Subgingival Plaque Microbiota by HighThroughput 16S rDNA Pyrosequencing. PLoS ONE, v. 8, n. 4, e61516, 2013.
APÊNDICE APÊNDICE A – Parecer do comitê de Ética em Pesquisa