O presente estudo foi o primeiro a avaliar os efeitos do exercício resistido sobre a reatividade vascular desencadeada pela insulina em artérias mesentéricas superiores de ratos. Uma sessão de exercício resistido aumentou os relaxamentos via IR/PI3K/NOS. Este aumento, se devem em parte a uma maior produção de NO, associado a um aumento da participação dos canais para K+ e da Na+/K+-ATPase. Além disso, foi observado um discreto aumento da via IR/MAPK/ET-1, entretanto sem promover prejuízos no relaxamento destes animais induzidos pela insulina. Conjuntamente, estes resultados demostram que o exercício resistido agudo é capaz de promover ajustes vasculares importantes que atuam diretamente no favorecimento do melhor controledo tônus vascular.
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