Pretende-se em trabalhos futuros fazer implantes crônicos de multieletrodos na área que corresponde ao HC reptiliano do lagarto tropical Tropidurus hispidus, a fim de realizar registros eletrofisiológicos com a finalidade de: 1) caracterizar os tipos de ondas eletroencefálicas durante os estágios de vigília e sono dessa espécie; 2) analisar se há a ocorrência de sono REM nessa espécie, em função da temperatura ambiental; 3) verificar se há a presença de neurônios espaciais no HC reptiliano; a fim de, afinal, 4) compreender melhor os processos evolutivos envolvidos na formação de memória entre os grupos de vertebrados.
REFERENCIAL BIBLIOGRÁFICO
Abellan, A., Legaz, I., Vernier, B., Retaux, S., Medina, L., 2009. Olfactory and amygdalar structures of the chicken ventral pallium based on the combinatorial expression patterns of LIM and other developmental regulatory genes. J Comp Neurol. 516, 166-186.
Aboitiz, F., 1999a. Comparative development of the mammalian isocortex and the reptilian dorsal ventricular ridge. Evolutionary considerations. Cereb Cortex. 9, 783-791.
Aboitiz, F., 1999b. Evolution of isocortical organization. A tentative scenario including roles of reelin, p35/cdk5 and the subplate zone. Cereb Cortex. 9, 655-661.
Aboitiz, F., Montiel, J., Lopez, J., 2002a. Critical steps in the early evolution of the isocortex: insights from developmental biology. Braz J Med Biol Res. 35, 1455-1472.
Aboitiz, F., Montiel, J., Lopez, J., 2002b. An hypothesis on the early evolution of the development of the isocortex. Brain Res Bull. 57, 481-483.
Aboitiz, F., Montiel, J., Morales, D., Concha, M., 2002c. Evolutionary divergence of the reptilian and the mammalian brains: considerations on connectivity and development. Brain Res Brain Res Rev. 39, 141-153.
Baiard, D. C., Conhecimento, evolução e complexidade na filosofia sintética de Herbert Spencer., Dissertação FFCLRP USP, Ribeirão Preto, 2008.
Bell, J. A., Livesey, P. J., Meyer, J. F., 2009. Environmental Enrichment Influences Survival Rate and Enhances Exploration and Learning But Produces Variable Responses to the Radial Maze in Old Rats. Dev. Psychobiol 51: 564-578.
Bennett, E. L., Rosenzweig, M. R. & Diamond, M. C., 1969. Rat brain: effects of environmental enrichment on wet and dry weights. Science 164: 825–826.
Bisler, S., Schleicher, A., Gass, P., Stehle, J. H., Zilles, K., Staiger, J. F., 2002. Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment. J Chem Neuroanat. 23, 187-198.
dorsal forebrain. Psyhobiology. 17, 445-449.
Bozon, B., Davis, S., Laroche, S., 2003a. A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval. Neuron. 40, 695-701.
Bozon, B., Kelly, A., Josselyn, S. A., Silva, A. J., Davis, S., Laroche, S., 2003b. MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos Trans R Soc Lond B Biol Sci. 358, 805-814.
Burmeister, S. S., Fernald, R. D., 2005. Evolutionary conservation of the egr-1 immediate-early gene response in a teleost. J Comp Neurol. 481, 220-232.
Cajal, S. R., 1904. Textura del sistema nervioso del hombre y de los vertebrados., vol. 1. Imprenta y Librería de Nicolás Moya, Madrid.
Christy, B., Nathans, D., 1989. DNA binding site of the growth factor-inducible protein Zif268. Proc Natl Acad Sci U S A. 86, 8737-8741.
Condorelli, D. F., Dell'Albani, P., Amico, C., Lukasiuk, K., Kaczmarek, L., Giuffrida- Stella, A. M., 1994. Glutamate receptor-driven activation of transcription factors in primary neuronal cultures. Neurochem Res. 19, 489-499.
Cummins, R. A., Walsh, R., Budtz-Olsen, O. E., Konstantinos, T. & Horsfall, C. R., 1973. Environmentally-induced changes in the brains of elderly rats. Nature 243: 516–518.
Davis, K. M., Burghardt, G. M., 2007. Training and long-term memory of a novel food acquisition task in a turtle (Pseudemys nelsoni). Behav Processes. 75, 225-230.
Day, L. B., Crews, D., Wilczynski, W., 2001. Effects of medial and dorsal cortex lesions on spatial memory in lizards. Behav Brain Res. 118, 27-42.
De La Iglesia, J. A., Lopez-Garcia, C., 1997a. A Golgi study of the principal projection neurons of the medial cortex of the lizard Podarcis hispanica. The Journal of Comparative Neurology. 000, 528-564.
De La Iglesia, J. A., Lopez-Garcia, C., 1997b. A Golgi study of the short-axon interneurons of the cell layer and inner plexiform layer of the medial cortex of the lizard Podarcis hispanica. The Journal of Comparative Neurology. 385, 565-598.
De La Iglesia, J. A., Martinez-Guijarro, F. I., Lopez-Garcia, C., 1994. Neurons of the medial cortex outer plexiform layer of the lizard Podarcis hispanica: Golgi and immunocytochemical studies. J Comp Neurol. 341, 184-203.
Diamond, M. C., Ingham, C. C., Johnson, R. E., Bennett, E. L. & Rosenzweig, M. R. Effects of environment on morphology of rat cerebral cortex and hippocampus. J. Neurobiol. 7: 75–85 (1976).
Diamond, M.C., Law, F., Rhodes, H., Lindner, B., Rosenzweig, M.R., Krech, D., Bennett, E.L., 1966. Increases in cortical depth and glia numbers in rats subjected to enriched environment. J. Comp. Neurol. 128: 117–126.
Font, E., Desfilis, E., Perez-Canellas, M., Alcantara, S., Garcia-Verdugo, J. M., 1997. 3-Acetylpyridine-induced degeneration and regeneration in the adult lizard brain: a qualitative and quantitative analysis. Brain Res. 754, 245- 259.
Ghosh, A., Ginty, D. D., Bading, H., Greenberg, M. E., 1994. Calcium regulation of gene expression in neuronal cells. J Neurobiol. 25, 294-303.
Greeberg, N., 1982. A forebrai atlas and stereotaxic technique for the lizard, Anolis carolinensis. Journal of Morphology. 174, 217-236.
Greenough, W. T. & Volkmar, F. R., 1973. Pattern of dendritic branching in occipital cortex of rats reared in complex environments. Exp. Neurol. 40: 491–504.
Gortz, N., Lewejohann, L., Tomm, M., Ambrée, O., Keyvani, K., Paulus, W., Sachser,. N., 2008. Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice. Behavioural Brain Research. 191: 43–48
Grisham, W., Powers, A. S., 1989. Function of the dorsal and medial cortex of turtles in learning. Behav Neurosci. 103, 991-997.
Grisham, W., Powers, A. S., 1990. Effects of dorsal and medial cortex lesions on reversals in turtles. Physiol Behav. 47, 43-49.
Guzowski, J. F., Setlow, B., Wagner, E. K., McGaugh, J. L., 2001. Experience- dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268. J Neurosci. 21, 5089-5098.
Hebb, D.O., 1947. The effects of early experience on problem solving at maturity. Am. Psychol. 2, 306–307.
Holloway, R. L., 1966. Dendritic branching: some preliminary results of training and complexity in rat visual cortex. Brain Res. 2: 393–396.
Hoogland, P. F., Vermeurlen-Van der Zee, E., Intrinsic and extrinsic connections of the cerebral cortex of lizards., Int. Symp. recent advances in understanding the structure and function of the forebrain en repteis., Frankfurt, 1988, pp. 20-29.
Ivazov, N. I., 1983. Role of the hippocampal cortex and dorsal ventricular ridge in conditioned reflex activity of the anguid lizard scheltopusik (Ophisaurus apodus). Neurosci Behav Physiol. 13, 397-403.
Johnson, D., Amaral, D. G., 1998. Hippocampus. In Sheperd GM (Ed.), The Synaptic Organization of the Brain., vol., New York.
Jones, M. W., Errington, M. L., French, P. J., Fine, A., Bliss, T. V., Garel, S., Charnay, P., Bozon, B., Laroche, S., Davis, S., 2001. A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci. 4, 289-296.
Kaczmarek, L., 1993. Molecular biology of vertebrate learning: is c-fos a new beginning? J Neurosci Res. 34, 377-381.
Kaczmarek, L., 2000. Gene expression in learning processes. Acta Neurobiol Exp (Wars). 60, 419-424.
Kandel, E. R., Schwartz, J. H., Jessell T, M., 2003. Principles of neural science, vol., New York: McGraw-Hill.
Kempermann, G., Kuhn, H. G. & Gage, F. H., 197. More hippocampal neurons in adult mice living in an enriched environment. Nature. 386: 493-495.
Knapska, E., Kaczmarek, L., 2004. A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK? Prog Neurobiol. 74, 183-211.
Krubitzer, L., 2007. The magnificent compromise: cortical field evolution in mammals. Neuron. 56, 201-208.
Lau, L. F., Nathans, D., 1987. Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci U S A. 84, 1182-1186.
Lemaire, P., Vesque, C., Schimitt, J., 1988. Two mouse genes encoding potential transcription factores with identical DNA-binding domains are activated by growth factors in cultured cells. Proc. Natl. Acad. Sci. USA. 85, 4691-4695.
Long, K. D., Salbaum, J. M., 1998. Evolutionary conservation of the immediate- early gene ZENK. Mol Biol Evol. 15, 284-292.
Lopez, J. C., Gomez, Y., Vargas, J. P., Salas, C., 2003a. Spatial reversal learning deficit after medial cortex lesion in turtles. Neurosci Lett. 341, 197-200.
Lopez, J. C., Vargas, J. P., Gomez, Y., Salas, C., 2003b. Spatial and non-spatial learning in turtles: the role of medial cortex. Behav Brain Res. 143, 109- 120.
Magalhães, A., Melo, P., Alves, C. J., Tavares, M. A., Souza, L., Summavielle, T. 2008. Exploratory Behavior in Rats Postnatally Exposed to Cocaine and Housed in an Enriched Environment. Ann. N.Y. Acad. Sci. 1139: 358–365.
Mangiamele, L.A.; Burmeister, S.S., 2008. Acoustically evoked immediate early gene expression in the pallium of female Túngara Frogs. Brain Behav. Evol. 72: 239-250.
Marchioro, M., Blank Mde, F., Mourao, R. H., Antoniolli, A. R., 2005. Anti- nociceptive activity of the aqueous extract of Erythrina velutina leaves. Fitoterapia. 76, 637-642.
Martinez-Guijarro, F. J., Freund, T. F., 1992. GABA-immunoreactive basal forebrain afferents innervate GABA-immunoreactive non-pyramidal cells in the cerebral cortex of the lizard Podarcis hispanica. Neuroscience. 51, 425-437.
Medina, L., Abellan, A., 2009. Development and evolution of the pallium. Semin Cell Dev Biol. 20, 698-711.
Mello, C. V., Vicario, D. S., Clayton, D. F., 1992. Song presentation induces gene expression in the songbird forebrain. Proc Natl Acad Sci U S A. 89, 6818- 6822.
Milbrandt, J., 1987. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science. 238, 797-799.
Mohammed, A. H., Zhu, S. W., Darmopil, S., Hjerling-Leffler, J., Ernfors, P., Winblad, B., et al., 2002. Environmental enrichment and the brain. Progress in Brain Research, 138, 109–133.
Mokin, M., Keifer, J., 2005. Expression of the immediate-early gene-encoded protein Egr-1 (zif268) during in vitro classical conditioning. Learn Mem. 12, 144-149.
Molowny, A., Martinez-Calatayud, J., Juan, M. J., Martinez-Guijarro, F. J., Lopez- Garcia, C., 1987. Zinc accumulation in the telencephalon of lizards. Histochemistry. 86, 311-314.
Induction of expression of genes encoding transcription factors in the rat brain elicited by behavioral training. Brain Res Bull. 28, 479-484.
Northcutt, R. G., Kass, J. H., 1995. The emergence and evolution of mammalian neocortex. Trends in Neurosciences. 18: 373-379.
O'Keefe, J., Dostrovsky J., 1971. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res. 34(1):171-5.
O'Leary, D. D., Nakagawa, Y., 2002. Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex. Curr Opin Neurobiol. 12, 14-25.
Olsson T., Mohammed A. H., Donaldson L. F., Henriksson B. G. and Seckl J. R., 1994. Glucocorticoid receptor and NGFI-A gene expression are induced in the hippocampus after environmental enrichment in adult rats. Molec. Brain Res. 23, 349–353.
Pace, T. W., Gaylord, R., Topczewski, F., Girotti, M., Rubin, B., Spencer, R. L., 2005. Immediate-early gene induction in hippocampus and cortex as a result of novel experience is not directly related to the stressfulness of that experience. Eur J Neurosci. 22, 1679-1690.
Pascual-Leone, A., Amedi, A., Fregni, F., Merabet, L. B., 2005. The plastic human brain cortex. Annu Rev Neurosci. 28, 377-401.
Petersohn, D., Schoch, S., Brinkmann, D. R., Thiel, G., 1995. The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2. J Biol Chem. 270, 24361-24369.
Peterson, E., 1980. Behavioral studies of telencephalic functions in reptiles. Plenum. 343-388.
Puelles, L., Kuwana, E., Puelles, E., Bulfone, A., Shimamura, K., Keleher, J., Smiga, S., Rubenstein, J. L. R., 2000. Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6 and Tbr-1. Journal of Comparative Neurology. 424: 409-438.
Puelles, L., Kuwana, E., Rubenstein, J. L. R., 1999. Comparison of the mammalian and avian telencephalon from the perspective of gene expression data. European Journal of Morphology. 37: 139-150.
Ribas, G., C., 2006. Considerations about the nervous system phylogenetic evolution, behavior, and the emergence of consciousness. Rev. Bras. Psiquiatr. 28(4): 326-338.
Ribeiro, S., Goyal, V., Mello, C. V., Pavlides, C., 1999. Brain gene expression during REM sleep depends on prior waking experience. Learn Mem. 6, 500- 508.
Ribeiro, S., Mello, C. V., Velho, T., Gardner, T. J., Jarvis, E. D., Pavlides, C., 2002. Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye- movement sleep. J Neurosci. 22, 10914-10923.
Ribeiro, S., Shi, X., Engelhard, M., Zhou, Y., Zhang, H., Gervasoni, D., Lin, S. C., Wada, K., Lemos, N. A., Nicolelis, M. A., 2007. Novel Experience Induces Persistent Sleep-Dependent Plasticity in the Cortex but not in the Hippocampus. Front Neurosci. 1, 43-55.
Rodriguez, F., Lopez, J. C., Vargas, J. P., Broglio, C., Gomez, Y., Salas, C., 2002. Spatial memory and hippocampal pallium through vertebrate evolution: insights from reptiles and teleost fish. Brain Res Bull. 57, 499-503.
Rosahl, T. W., Spillane, D., Missler, M., Herz, J., Selig, D. K., Wolff, J. R., Hammer, R. E., Malenka, R. C., Sudhof, T. C., 1995. Essential functions of synapsins I and II in synaptic vesicle regulation. Nature. 375, 488-493.
Rosenzweig, M. R., Krech, D., Bennett, E. L. & Diamond, M. C., 1962. Effects of environmental complexity and training on brain chemistry and anatomy. J. Comp. Physiol. Psychol. 55: 429–437.
Shumway, C. A., 2008. Habitat complexity, brain, and behavior. Brain Behav Evol. 72, 123-134.
Sluys, M. V., Rocha, C. F. D., Vrcibradic, D., Galdino, C. A. B., Fontes, A. F., 2004. Diet, activity, and microhabitat use of two syntopic Tropidurus species (Lacertilia: Tropiduridae) in Minas Gerais, Brazil. Journal of Herpetology. 38, 606-611.
Smith-Fernandez, A., Pieau, C., Reperant, J., Boncinelli, E., Wassef, M., 1998. Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes. Development. 125: 2099-2111.
Soulé, J,. Penke, Z., Kanhema, T., Alme, M. N., Laroche, S., Bramham, C. R., 2008. Object-place recognition triggers rapid induction of plasticity-related immediate early genes and synaptic in the rat dentate gyrus. Neural Plasticity. 2008: 1-12.
Verlag. Berlin, Germany.
Thode, C., Bock, J., Braun, K., Darlison, M. G., 2005. The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus. Neuroscience. 130, 611-617.
Toscano, C. D., McGlothan, J. L., Guilarte, T. R., 2006. Experience-dependent regulation of zif268 gene expression and spatial learning. Exp Neurol. 200, 209-215.
Towbin, H., Staehelin, T., Gordon, J., 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 76, 4350-4354.
Turner, A.M., Greenough, W.T., 1985. Differential rearing effects on rat visual cortex synapses: I. Synaptic and neuronal density and synapses per neuron. Brain Res. 329: 195–203.
Vertes, R. P., Hoover, W. B., 2008. Projections of the paraventricular and paratenial nuclei of the dorsal midline thalamus in the rat. J Comp Neurol. 508, 212-237.
Vitt, L. J., Caldwell, J. P., Zani, P. A., Titus, T. A., 1997. The role of habitat shift in the evolution of lizard morphology: evidence from tropical Tropidurus. Proc Natl Acad Sci U S A. 94, 3828-3832.
Zug, G. R., 1993. Herpetology: an Introductory Biology of Amphibians and Reptiles. San Diego, Academic Press. 527.
Wallace, C. S., Withers, G. S., Weiler, I. J., George, J. M., Clayton, D. F., Greenough, W. T., 1995. Correspondence between sites of NGFI-A induction and sites of morphological plasticity following exposure to environmental complexity. Brain Res Mol Brain Res. 32, 211-220.
Walsh, R. N., Budtz-Olsen, O. E., Penny, J. E. & Cummins, R. A., 1969. The effects of environmental complexity on the histology of the rat hippocampus. J. Comp. Neurol. 137: 361–366.
Winson J., 1972. Interspecies differences in the occurrence of theta. Behav Biol. 7(4):479-87.
Winson J., 1978. Loss of hippocampal theta rhythm results in spatial memory deficit in the rat. Science. 201(4351):160-3.
contrasted: Evidence from genes to behavior. J Comp Neurol. 475, 143- 162.