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85 9. R. Quinn, Comparing rat's to human's age: how old is my rat in people years?, Nutrition

(Burbank, Los Angeles County, Calif.), 21 (2005) 775-777.

10. J. Meites, R.W. Steger, H.H. Huang, Relation of neuroendocrine system to the reproductive decline in aging rats and human subjects, Federation proceedings, 39 (1980) 3168-3172.

11. S. Amaral, P. Mota, A.S. Rodrigues, L. Martins, P.J. Oliveira, J. Ramalho-Santos, Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak, FEBS letters, 582 (2008) 4191-4196.

12. A. Banerjee, Anuradha, K. Mukherjee, A. Krishna, Testicular glucose and its transporter GLUT 8 as a marker of age-dependent variation and its role in steroidogenesis in mice, Journal of experimental zoology. Part A, Ecological genetics and physiology, 321 (2014) 490-502.

13. M.G. Alves, A.D. Martins, C.V. Vaz, S. Correia, P.I. Moreira, P.F. Oliveira, S. Socorro, Metformin and male reproduction: effects on Sertoli cell metabolism, Br. J. Pharmacol., 171 (2014) 1033-1042.

14. T.R. Dias, M.G. Alves, J. Silva, A. Barros, M. Sousa, S. Casal, B.M. Silva, P.F. Oliveira, Implications of epigallocatechin-3-gallate in cultured human Sertoli cells glycolytic and oxidative profile, Toxicol. In Vitro, 41 (2017) 214–222.

15. M.G. Alves, P.J. Oliveira, R.A. Carvalho, Substrate selection in hearts subjected to ischemia/reperfusion: role of cardioplegic solutions and gender, NMR in biomedicine, 24 (2011) 1029-1037.

16. D.S. Wishart, D. Tzur, C. Knox, R. Eisner, A.C. Guo, N. Young, D. Cheng, K. Jewell, D. Arndt, S. Sawhney, C. Fung, L. Nikolai, M. Lewis, M.A. Coutouly, I. Forsythe, P.

Tang, S. Shrivastava, K. Jeroncic, P. Stothard, G. Amegbey, D. Block, D.D. Hau, J.

Wagner, J. Miniaci, M. Clements, M. Gebremedhin, N. Guo, Y. Zhang, G.E. Duggan, G.D. Macinnis, A.M. Weljie, R. Dowlatabadi, F. Bamforth, D. Clive, R. Greiner, L. Li, T.

Marrie, B.D. Sykes, H.J. Vogel, L. Querengesser, HMDB: the Human Metabolome Database, Nucleic acids research, 35 (2007) D521-526.

17. L.W. Sumner, A. Amberg, D. Barrett, M.H. Beale, R. Beger, C.A. Daykin, T.W.M. Fan, O. Fiehn, R. Goodacre, J.L. Griffin, T. Hankemeier, N. Hardy, J. Harnly, R. Higashi, J.

Kopka, A.N. Lane, J.C. Lindon, P. Marriott, A.W. Nicholls, M.D. Reily, J.J. Thaden, M.R.

Viant, Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI), Metabolomics : Official journal of the Metabolomic Society, 3 (2007) 211-221.

86 18. F. Savorani, G. Tomasi, S.B. Engelsen, icoshift: A versatile tool for the rapid alignment of 1D NMR spectra, Journal of magnetic resonance (San Diego, Calif. : 1997), 202 (2010) 190-202.

19. F. Dieterle, A. Ross, G. Schlotterbeck, H. Senn, Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics, Analytical chemistry, 78 (2006) 4281-4290.

20. H.H. Zhang, J. Huang, K. Duvel, B. Boback, S. Wu, R.M. Squillace, C.L. Wu, B.D.

Manning, Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway, PloS one, 4 (2009) e6189.

21. J. Carrola, V. Bastos, I. Jarak, R. Oliveira-Silva, E. Malheiro, A.L. Daniel-da-Silva, H.

Oliveira, C. Santos, A.M. Gil, I.F. Duarte, Metabolomics of silver nanoparticles toxicity in HaCaT cells: structure-activity relationships and role of ionic silver and oxidative stress, Nanotoxicology, 10 (2016) 1105-1117.

22. M.N. Triba, L. Le Moyec, R. Amathieu, C. Goossens, N. Bouchemal, P. Nahon, D.N.

Rutledge, P. Savarin, PLS/OPLS models in metabolomics: the impact of permutation of dataset rows on the K-fold cross-validation quality parameters, Molecular bioSystems, 11 (2015) 13-19.

23. L. Berben, S.M. Sereika, S. Engberg, Effect size estimation: methods and examples, International journal of nursing studies, 49 (2012) 1039-1047.

24. J. Xia, D.S. Wishart, Using MetaboAnalyst 3.0 for Comprehensive Metabolomics Data Analysis, Current protocols in bioinformatics, 55 (2016) 14.10.11-14.10.91.

25. L.R. Franca, T. Ogawa, M.R. Avarbock, R.L. Brinster, L.D. Russell, Germ cell genotype controls cell cycle during spermatogenesis in the rat, Biology of reproduction, 59 (1998) 1371-1377.

26. F. Boussouar, M. Benahmed, Lactate and energy metabolism in male germ cells, Trends in endocrinology and metabolism: TEM, 15 (2004) 345-350.

27. F. Deepinder, H.T. Chowdary, A. Agarwal, Role of metabolomic analysis of biomarkers in the management of male infertility, Expert review of molecular diagnostics, 7 (2007) 351-358.

28. J.L. Griffin, J. Troke, L.A. Walker, R.F. Shore, J.C. Lindon, J.K. Nicholson, The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy, FEBS letters, 486 (2000) 225-229.

29. J.M. Lawler, W.S. Barnes, G. Wu, W. Song, S. Demaree, Direct antioxidant properties of creatine, Biochemical and biophysical research communications, 290 (2002) 47-52.

87 30. T. Yamamoto, I. Horii, T. Yoshida, Integrated NMR-based metabonomic investigation of early metabolic effects of ethylene glycol monomethyl ether (EGME) on male reproductive organs in rats, The Journal of toxicological sciences, 32 (2007) 515-528.

31. L. Rato, M.G. Alves, S. Socorro, R.A. Carvalho, J.E. Cavaco, P.F. Oliveira, Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells cultured in vitro, Bioscience reports, 32 (2012) 61-69.

32. S.M. Mendis-Handagama, S.J. Gelber, Signs of aging are apparent in the testis interstitium of Sprague Dawley rats at 6 months of age, Tissue & cell, 27 (1995) 689- 699.

33. M. Auroux, N.N. Nawar, N. Rizkalla, Testicular aging: vascularization and gametogenesis modifications in the Wistar rat, Archives of andrology, 14 (1985) 115- 121.

34. B.V.D. Neves, F. Lorenzini, D. Veronez, E.P. Miranda, G.D. Neves, R. Fraga, Numeric and volumetric changes in Leydig cells during aging of rats, Acta cirurgica brasileira, 32 (2017) 807-815.

35. S.J. Sokanovic, M.M. Janjic, N.J. Stojkov, A.Z. Baburski, M.M. Bjelic, S.A. Andric, T.S.

Kostic, Age related changes of cAMP and MAPK signaling in Leydig cells of Wistar rats, Experimental gerontology, 58 (2014) 19-29.

36. D. Sahoo, A. Roy, G. Chainy, Rat testicular mitochondrial antioxidant defence system and its modulation by aging, Acta Biol Hung., 59 (2008) 413-424.

37. M.V. Lobo, F.J. Alonso, R.M. del Rio, Immunohistochemical localization of taurine in the male reproductive organs of the rat, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 48 (2000) 313-320.

38. S. Meizel, C. Lui, P. Working, R. Mrsny, Taurine and hypotaurine: their effects on motility, capacitation and the acrosome reaction of hamster sperm in vitro and their presence in sperm and reproductive tract fluids of several mammals, Development, Growth & Differentiation, 22 (1980) 483-494.

39. D.E. Boatman, B.D. Bavister, E. Cruz, Addition of hypotaurine can reactivate immotile golden hamster spermatozoa, Journal of andrology, 11 (1990) 66-72.

40. O.I. Aruoma, B. Halliwell, B.M. Hoey, J. Butler, The antioxidant action of taurine, hypotaurine and their metabolic precursors, Biochemical Journal, 256 (1988) 251-255.

41. R.J. Aitken, G.N. De Iuliis, J.M. Finnie, A. Hedges, R.I. McLachlan, Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: development of diagnostic criteria, Human Reproduction, 25 (2010) 2415- 2426.

88 42. I.M. Fearnley, J. Carroll, R.J. Shannon, M.J. Runswick, J.E. Walker, J. Hirst, GRIM-

19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I), The Journal of biological chemistry, 276 (2001) 38345-38348.

43. H.M. Brown-Borg, W.T. Johnson, S.G. Rakoczy, Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice, Age (Dordrecht, Netherlands), 34 (2012) 43-57.

44. A. Baracca, F. Chiaradonna, G. Sgarbi, G. Solaini, L. Alberghina, G. Lenaz, Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells, Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1797 (2010) 314-323.

45. D.S. Aaronson, R. Iman, T.J. Walsh, J. Kurhanewicz, P.J. Turek, A novel application of 1H magnetic resonance spectroscopy: non-invasive identification of spermatogenesis in men with non-obstructive azoospermia, Human reproduction (Oxford, England), 25 (2010) 847-852.

46. D.E. Vance, J.E. Vance, Physiological consequences of disruption of mammalian phospholipid biosynthetic genes, Journal of Lipid Research, 50 (2009) S132-137.

47. M. Zhang, H. Zhang, H. Li, F. Lai, X. Li, Y. Tang, T. Min, H. Wu, Antioxidant Mechanism of Betaine without Free Radical Scavenging Ability, Journal of agricultural and food chemistry, 64 (2016) 7921–7930.

48. M.J. Jones, S.J. Goodman, M.S. Kobor, DNA methylation and healthy human aging, Aging cell, 14 (2015) 924-932.

49. A.A. Johnson, K. Akman, S.R.G. Calimport, D. Wuttke, A. Stolzing, J.P. de Magalhães, The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease, Rejuvenation Research, 15 (2012) 483-494.

50. F. Maccari, A. Arseni, P. Chiodi, M.T. Ramacci, L. Angelucci, Levels of carnitines in brain and other tissues of rats of different ages: effect of acetyl-L-carnitine administration, Experimental gerontology, 25 (1990) 127-134.

51. J. Mansfeld, N. Urban, S. Priebe, M. Groth, C. Frahm, N. Hartmann, J. Gebauer, M.

Ravichandran, A. Dommaschk, S. Schmeisser, D. Kuhlow, S. Monajembashi, S.

Bremer-Streck, P. Hemmerich, M. Kiehntopf, N. Zamboni, C. Englert, R. Guthke, C.

Kaleta, M. Platzer, J. Suhnel, O.W. Witte, K. Zarse, M. Ristow, Branched-chain amino acid catabolism is a conserved regulator of physiological ageing, NATURE COMMUNICATIONS, 6 (2015) 10043-10054.

89 52. R.H. Houtkooper, C. Argmann, S.M. Houten, C. Canto, E.H. Jeninga, P.A. Andreux, C. Thomas, R. Doenlen, K. Schoonjans, J. Auwerx, The metabolic footprint of aging in mice, Scientific reports, 1 (2011) 134.

53. G. D'Antona, M. Ragni, A. Cardile, L. Tedesco, M. Dossena, F. Bruttini, F. Caliaro, G.

Corsetti, R. Bottinelli, M.O. Carruba, A. Valerio, E. Nisoli, Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice, Cell metabolism, 12 (2010) 362-372.

54. M. Iwasa, Y. Kobayashi, R. Mifuji-Moroka, N. Hara, H. Miyachi, R. Sugimoto, H.

Tanaka, N. Fujita, E.C. Gabazza, Y. Takei, Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis, PloS one, 8 (2013) e70309.

55. P.M. Engelfriet, E.H. Jansen, H.S.J. Picavet, M.E. Dollé, Biochemical markers of aging for longitudinal studies in humans, Epidemiologic reviews, 35 (2013) 132-151.

Chapter 4

Seminal plasma metabolites and aging: Impact on male