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Otimização da resposta de células T CD8+ de memória ao herpes simplex virus-1 utilizando terapia genética com interleucina-15 e interleucina-21

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(15)

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(16)

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(17)

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(18)

, 5?1-1"2 ) < "486*!74 C 5I N1'R c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cXd> &'! & < /I 5I c1'R> * G-* *22" 74)-AB' ? +*)7")" &*1" 178"AB' )' & )' (7!"1 "' , < *. "1C 9T Z U Z *. "1C ># 2 & 2 2B' 5"&"D*2 )* &!')-D7! "1."2 G-"4.7)")*2 )* .7&' *+ !*2&'2." " (;!-2 * & 2 )* C *2."/*1*5*4)' -+" 178"AB' *4.!* " !*2&'2." 74"." * ")"&.".7(" <Z U Z *. "1C ># &"&*1 )*.*!+74"4.* )"2 & 2 * 2-" ".7("AB' (7" , 5'+' &!7+*7!" 1746" )* &!')-AB' )* α

(19)

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(20)

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(21)

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