e72 14th International Congress on Infectious Diseases (ICID) Abstracts 27.012
Antioxidant nutritional status and superoxide dismutase (SOD) levels in school—aged children infected with human immunodeficiency virus
R. Vega Patin, F.L. Ceragioli Oliveira, R.C. de Menezes Succi, O.M. Silvério Amâncio, A.D.F. Thomé Barbosa Gouvea, C. Zanin Palchetti∗, D.M. Machado, F. Ancona Lopez
Universidade Federal de São Paulo - UNIFESP/EPM, São Paulo, Brazil
Background: Antioxidant micronutrients play an impor-tant role in HIV infection. Deficiencies of micronutrients are associated with immune deficiency, rapid disease pro-gression and mortality. The aim of the study was evaluate antioxidant nutritional status in prepubertal school-aged children in two situations: HIV exposure and the control group.
Methods: Prospective transversal study including 51 HIV-infected children attended at the Pediatric Infectious Disease Clinic - Universidade Federal de São Paulo, São Paulo city, Brazil and their respective exposed siblings not infected by HIV (n = 31) and the ones not exposed to HIV (n = 32). Antioxidant substances related to the clinical, dietary and biochemical variables in the groups were evaluated.
Results: Vitamin A, C, E, beta-carotene, licopene, zinc and copper intake and plasma levels of vitamins A, C, E, beta-carotene, serum copper and superoxide dismutase (SOD) and protein C reactive, did not significantly differ in the groups. Major probability of vitamin A inadequacy was identified in the HIV-infected group (43.1%) as well as in the exposed but non-infected by HIV (48.4%), when compared to the non-exposed to HIV (37.5%) (P> 0.05). Lower rates of dietary vitamin E in HIV-infected children with inadequate trans fatty acid intake (P< 0.005) were verified. In the three studied groups, vitamin E correlated to the dietary saturated and polyunsaturated fatty acid (P< 0.007). Lower rates of the erythrocyte and serum zinc (P< 0.02) were verified in the HIV-infected children, when compared to the other groups. In the same group, correlation between dietary and bio-chemical values for vitamin C (r = 0.34;P= 0.01) and serum zinc (r = 0.37;P= 0.008); serum copper with SOD (r = 0.30) and with serum zinc (r = 0.43) and an inverse correlation of the erythrocyte zinc with the serum copper (r = -0.31) and with SOD (r = -0.50) were found. Plasma levels of vitamin E, licopene and betacarotene were related to CD4 count (P< 0.05) but negatively to the viral load (P< 0.02).
Conclusion: HIV-infected school-aged children without severe infectious processes in the last year presented oxidative stress by the chronic viral infection, allied to infectious processes, promoting increase in the demand of antioxidant. Interdisciplinary accompaniment has become essential, emphasizing adequate dietary in antioxidant micronutrient intake by HIV-infected children.
doi:10.1016/j.ijid.2010.02.1648
27.013
Lipodystrophy and antioxidants in school-aged children infected with human immunodeficiency virus
R. Vega Patin, F.L. Ceragioli Oliveira, R.C. de Menezes Succi, D.M. Machado, C. Zanin Palchetti∗, S. Pessoa, O.M. Silvério
Amâncio, F. Ancona Lopez
Universidade Federal de São Paulo - UNIFESP/EPM, São Paulo, Brazil
Background: To identify association between clinical-metabolic repercussions of the lipodystrophy with micronu-trient nutritional status and the enzyme superoxide dismutase in HIV-infected children.
Methods:Prospective and transversal study was assessed in 51 HIV-infected children attended at the Pediatric Infec-tious Disease Clinic - Universidade Federal de São Paulo, São Paulo city, Brazil. The clinical, nutritional and biochemical variables were related to the presence or absence of clinical lipodystrophy.
Results:Lipodystrophy was present in 25.5% of the chil-dren. This group was identified for subjects of younger age at the moment of diagnosis and antiretroviral ther-apy (ART) was more damaging concerning current clinical and immune status (P< 0.03). The current use and the time lapse of estavudine use (D4T) were related to lipodystro-phy presence (P< 0.04). The lipodystrophic group presented higher trunk-arm ratio and lower values of phase angle. The dietary energy, macronutrient and micronutrient intake did not differ in the groups. The prevalence of hipertriglyc-eridemia and immune damage were verified in the first group (P< 0.008). Lipodystrophy was related to fast insulin values, glutamic piruvic transaminase (GPT) and HOMA (P< 0.02). Biochemical levels of micronutrients and superoxide dismu-tase (SOD) did not vary in the groups (P> 0.05). Multiple regression analysis showed that 37% of the trunk-arm ratio was explained by triglycerides, HOMA and SOD variables and the time of protease inhibitor use, when controlled by inad-equate saturated fatty acid intake (more than 7% of total energy).
Conclusion:Although the variables assessed in this study were associated to trunk-arm ratio, there were other fac-tors that must be investigated in order to prevent or to minimize the damages caused by the oxidative stress, in order to decrease the cardiovascular disease risk factors in HIVinfected children.
doi:10.1016/j.ijid.2010.02.1649
27.014
Factors influencing pregnancy among HIV positive women receiving anti-retroviral therapy in Tororo district, Uganda
M. Busuulwa
Medical Epidemiologist, Kampala, US, Uganda
