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Detection and removal of biases in the analysis of next-generation sequencing reads.

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Academic year: 2017

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Figure 2. Mappability within genomic regions. (A) Mean mappability density values within internal exons and within the exons and introns flanking them
Figure 3. GRO-seq reads localization along exons and introns. Exons were aligned by their 3 9 ss (left panel) or by their 5 9 ss (right panel)
Figure 4. Control analyses of GRO-seq reads. (A) Analysis of 36,905 exonic compositions regions (ECRs) obtained from [32]
Figure 5. Analysis of effect of contamination of run-on experiment with mature RNA. (A) Mean number of GRO-seq read densities within exons and their flanking exons and introns as a function of expression levels obtained from [27], following normalization b

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