Fludarabine induces apoptosis in chronic lymphocytic leukemia - the role of P53, Bcl-2, Bax, Mcl-1, and Bag-1 proteins

The aim of this study was to determine the expression of proliferative (Mcm-2, Mcm-5 and geminin) and apoptotic (Bcl-2 and Bax) proteins in samples from two distinct families

Expressão dos genes anti-apoptóticos a1, bcl-2, bcl-x L , bcl-w, c-flip, ciap- 1, ciap-2 e mcl-1 nos grupos de pacientes com LMC em remissão citogenética e refratários após

The main findings are as follows: (1) DEX preconditioning reduced MDA and increased SOD activity in the A549; (2) DEX precon- ditioning increased the Bcl-2/Bax ratio and decreased

Furthermore, treatment with MT-3 caused a dose-de- pendent increase in Bcl-2 levels and the levels of Bcl-2 in SAMP8 mice treated with high doses of MT-3 were signiicantly higher

Objective: In the present study, the expression of anti-apoptotic (XIAP and Bcl-2) and apoptotic (cytochrome C, caspase 9, APAF-1), caspase 3 and the Smac/DIABLO genes related to

the genetic framework; Genetic and molecular analysis of programmed cell death in Drosophila; The caspases: consequential cleavage; Regulation of apoptosis by the bcl-2 family

the genetic framework; Genetic and molecular analysis of programmed cell death in Drosophila; The caspases: consequential cleavage; Regulation of apoptosis by the bcl-2 family

Esses resultados mostraram que o provável gene alvo regulado pelo let7d – NME6 (inibidor de p53) e o alvo para miR-29b – MCL-1 (anti-apoptótico da família do BCL-2 ),