A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.

In summary, this study showed that inhibition of AR activity caused increased activation of Wnt/ β -catenin pathway and this increased activation promoted androgen-independent growth

To explore whether S100A6 promotes PDAC cell migration and invasion via regulation of β - catenin, we transfected stable β -catenin-knockdown Panc-1 cells with a S100A6

We favor the possibility of a Wnt/ b -catenin-Mstn negative feedback loop, as our experimental evidence points towards a specific interaction, direct or indirect, between Wnt/

We find that SIRT1 overexpression inhibits the growth of colon cancer cells dependent on b -catenin activity, suppresses the localization of b -catenin to the nucleus, and

80% reduction of Wnt/ b -catenin signaling had no effect on the cell growth or viability of MDA-MB-231, MCF7, and DLD-1 cells, lines that were sensitive to both PORCN siRNA and

We aimed, on the one hand, to inhibit dedifferentiation due to the RET/PTC junction oncogene by siRNA and, on the other hand, to investigate a role of Wnt/ b -catenin pathway in

In summary, in addition to inhibiting cell growth by reducing proliferation and inducing apoptosis, Huaier reduces cell mobility in ovarian cancer cells via the AKT/GSK3 b / b

However HCT116 colon cancer cells that are known to exhibit high levels of endogenous Wnt pathway activity due to an intrinsic mutation in the b -catenin gene ( D S45) showed