Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations.

To further study the importance of CD8 T cells in the immunity to experimental malaria, T cell clones were obtained from spleen cells of BALB/c mice immunized with

To control for the latter, we quantified epitope-specific CD8 + T cell populations in the spleen of LCMV-infected mice [16] and found that eight days after LCMV challenge, the

To link the reduced GC responses in old mice ( Fig 2 ) with cell-intrinsic migratory defects of the naïve CD4 + T cells ( Fig 4 ), we adoptively transferred sorted naïve CD4 + T

To evaluate the outcome of exposure of lymphocytes to tumor cells, 2x10 6 bulk PBMCs and splenocytes or isolated human and murine CD4 + T cells either

Increased expression of Rev3 in human breast epithelial cancer cell lines compared to non- neoplastic human breast epithelial cells MCF-12A, and in human breast tumors compared

To characterize the phenotype and function of human NK cells, and to specifically study if HSV-2 infection drives human NK cell differentiation, peripheral blood was obtained

Our data indicate that while the development of single positive CD4 + and CD8 + T cells in the thymus remained intact in granzyme B-deficient mice, the peripheral pool of CD8 + T

As the diversity of the naı¨ve T cell repertoire is critical to defend against new infections and malignancies, the loss and slow restoration of the naı¨ve T cell population