Neoadjuvant Breast Cancer
HVFX 2011-2015
Neoadjuvant CT Breast Cancer: Why?
• Inoperable
• Inflammatory
• Stage III – any cN+
• Large operable cN0 w favorable biology
• Very important: pCR correlates w survival
Neoadjuvant CT Breast Cancer HVFX 2011-2015
• N=45 patients
• 44 women, 1 man
Neoadjuvant CT Breast Cancer HVFX 2011-2015: Age
0 2 4 6 8 10 12 20
30 40 50 60 70 80
Age of patients
Neoadjuvant CT Breast Cancer HVFX 2011-2015: cT
0 5 10 15 20 25 cT1
cT2 cT3 cT4
Neoadjuvant CT Breast Cancer HVFX 2011-2015: cN
0 5 10 15 20 25 30 35 40
cN0 cN1 cN2 cN3
Number of patients
Neoadjuvant CT Breast Cancer HVFX 2011-2015: cT & pT
0 5 10 15 20 25
0 is 1 2 3 4
T response to neoadj CT
Neoadjuvant CT Breast Cancer HVFX 2011-2015: cN & pN
0 5 10 15 20 25 30 35 40
0 1 2 3
N response to NeoAdjuvant CT
Neoadjuvant Breast Cancer
HVFX 2011-2015: Relapse & death-biology
0 1 2 3 4 5 6
Her2 TN Low PgR LKi67 80%
Biology of relapsed or dead patients (n=13)
Neoadjuvant Breast Cancer
HVFX 2011-2015: Relapse & death-staging
0 1 2 3 4 5 6 7 8
M1 T4 ypN2a
Staging characteristics of relapses or dead women
Neoadjuvant Breast Cancer HVFX 2011-2015: Conclusion
• Unfavorable staging still determinant in
prognosis: tumor burden even w favorable biology
• The five TNBC in the dataset all have had
Neoadjuvant Breast Cancer HVFX 2011-2015: Thank you!
