1Division of Plastic Surgery, Hospital das Clínicas, São Paulo University
Medical School - São Paulo/SP, Brazil.
2Hospital Universitário, University of São Paulo - São Paulo/SP, Brazil.
Email: [email protected]
Received for publication on October 13, 2006. Accepted for publication on October 16, 2006.
REVIEW
COMPLEX WOUNDS
Marcus Castro Ferreira1, Paulo Tuma Júnior1,Viviane Fernandes Carvalho1, Fábio Kamamoto2
Ferreira MC, Tuma Jr. P,Carvalho VF, Kamamoto F. Complex wounds. Clinics. 2006;61(6):571-8.
Complex wound is the term used more recently to group those well-known difficult wounds, either chronic or acute, that challenge medical and nursing teams. They defy cure using conventional and simple “dressings” therapy and currently have a major socioeconomic impact. The purpose of this review is to bring these wounds to the attention of the health-care community, suggesting that they should be treated by multidisciplinary teams in specialized hospital centers. In most cases, surgical treatment is unavoidable, because the extent of skin and subcutaneous tissue loss requires reconstruction with grafts and flaps. New technologies, such as the negative pressure device, should be introduced. A brief review is provided of the major groups of complex wounds—diabetic wounds, pressure sores, chronic venous ulcers, post-infection soft-tissue gangrenes, and ulcers resulting from vasculitis.
KEYWORDS: Complex wounds. Socioeconomic impact. Surgical treatment. Skin grafting. Skin flaps.
Expectancy of a longer life is recognized as one of ma-jor contributions afforded by modern civilization; however, improvement of quality of life has not necessarily followed that increase in life years. On the contrary, older populations may develop problems related to longevity that can compromise their quality of life.
Losses of cutaneous integument, represented not only by skin disruption but also by loss of subcutaneous tissues, sometimes including even muscle and bone, have been gen-erally defined in medical textbooks as “wounds”. There are striking differences between simple wounds, for example surgical wounds or skin scratches, and those chronic wounds that do not heal primarily and demand specialized care, mostly in hospitals. However, the latter have not mer-ited enough attention by surgeons who consider the treat-ment of wounds to be a less sophisticated aspect of the pro-fession, and consequently of no special interest.
More recently, the increasing number of aged patients and the frequency of these more difficult wounds has started
to attract the attention not only of doctors and nurses but also of health-care administrators worried about the impact of the cost of these wounds on their hospital budgets.
In Brazil, the topic has not attained widespread inter-est, but in the State of São Paulo and in particular in Hos-pital das Clínicas of São Paulo University Medical College, the problem is gaining more importance in this new cen-tury.
A proposal was made by a group working at the Divi-sion of Plastic Surgery of the Institution to form a multidisciplinary group including doctors (plastic and vas-cular surgeons, dermatologists) and wound therapy nurses.1 It was formally approved in 2006, and its main goal is the study of the so-called “complex wounds”.
But what are complex wounds?
and the challenge they pose for medical and nursing teams. One or more of the following conditions must be present for a wound to be categorized as a “complex” type: 1 – Extensive loss of the integument is an important
crite-rion, whether it is an acute or chronic wound. Chronic wounds are defined as wounds that have not healed expontaneously in 3 months2 and usually have a com-mon pattern of the complexity.
2 – Infection is frequently present as a complication in chronic wounds and in itself may be the cause of the problem that resulted in tissue loss, as happens in ag-gressive infections like Fournier’s gangrene.
3 – Compromised viability of superficial tissues—clear necrosis, or signs of circulation impairment either lo-calized or more extensive, usually in the limbs, lead-ing to extensive loss of substance.
4 –Association with systemic pathologies that impair nor-mal healing causing wounds to fail to heal with simple care and requiring special attention. Feet ulcers in dia-betic patients and many forms of vasculitis are com-mon examples.
We thus consider the most commonly seen complex wounds, needing special care by a specialized group, as the following:
1 – Wounds in the lower extremity of diabetic patients, 2 – Pressure ulcers,
3 – Chronic venous ulcers,
4 – Wounds following extensive necrotic processes caused by infections (Fournier’s and other), and 5 – Chronic wounds related to vasculitis and
immuno-suppressive therapy that have not healed using sim-ple care.
Burns might be included in this group of complex wounds (and indeed they are, in many instances, very com-plex wounds), but tradionally they are separated from this group, basically because burns have been regarded for some time to be a special condition that should be treated in spe-cialized burn centers.
Using these concepts, over the last 5 years we have es-tablished measures to ensure a better understanding of the prevalence of these complex wounds in our institution (in-cluding the establishment of an electronic database) and to study and revise the procedures usually used to treat them, ie, dressings, surgical options, and new technologies that have recently become available, such as the negative pressure on wounds (vacuum systems).
It has already become clear to us that these complex wounds should usually be treated using surgical procedures instead of leaving them to clinical and expectant measures. Additionally, débridements, skin grafting, and flap coverage should be indicated sooner than has been done traditionally.
Determining that the majority of these complex wounds should be considered “surgical cases” and not just “cases for dressings” surely represents the major turning point of a new policy to provide more stable coverage of the wounds, thus improving the quality of life. It should re-duce the time of hospitalization and the cost of treatment. Preventative measures are also essential.
Complex wounds will be briefly reviewed, and main factors of policies that will produce faster and stable clo-sure of these wounds—awareness of the importance for the health-care system, complexity of the treatment, and cur-rent best surgical approaches—will be emphasized.
Wounds in diabetic patients
It is well known that diabetes mellitus is a chronic multi-factorial disease. Global prevalence of diabetes was 120 mil-lion in 1996, but predictions for 2030 suggests values as high as 366 million, due to longer life expectancies, obesity, and sedentary life styles.3,4,5 In Brazil, the diabetic population is estimated to be approsimately 10 million.6 In 2001, persons throughout Brazil who were 40 years old or older were in-vited to participate in community screening for diabetes as part of the Brazilian Ministry of Health’s Plan for the Reor-ganization of Care for Arterial Hypertension and Diabetes Mellitus. Of the 30.2 million persons in the target population, 22.1 million (73.0%) were examined, and 3.5 million tested (15.7%) positive for elevated blood glucose levels.7
Among the complications that most frequently affect the diabetic individual are cardio-, retino-, and nephropathies; however, wounds in the lower extremity also are a major burden for the patient and health system.8,9,10
Such wounds are usually chronic, mostly in the feet, and treatment is difficult; all too often, these wounds do not heal primarily.11,12 Simple control of glucose blood lev-els, although important, is not necessarily followed by heal-ing these ulcers.13,14 Frequently, wounds evolve with exten-sive necrosis and infectious processes that may lead to am-putation of body parts, even of limbs.15,16,17,18
Modern treatment of this pathology includes evaluation not only of the vascular status,28,29,30 but also of the neu-ropathy, using more precise tests to assess the sensibility of the feet,31 such as the PSSD™(Pressure Specified Sen-sory Device) described by Lee Dellon of Baltimore32; in use at the Hospital das Clínicas.33
This wound should be treated surgically and as soon as possible, removing necrotic tissues34,35,36 and providing wound bed preparation37,38 using specific dressings39,40 or negative pressure41,42,43 (vacuum devices). Closure should be achieved as soon as possible with skin grafting,44,45,46 local flaps,47,48,49,50 or microsurgical flaps.51,52,53
With these measures, we expect to reduce the signifi-cant personal and economic costs caused by the “diabetic foot”—the resulting longer stay in hospital, longer reha-bilitation, and need for special care. Amputations should be avoided at all costs, as they are no longer the only al-ternative for treatment of the ulcer after failure of conserva-tive measures to heal the ulcer, even if associated with com-plications like osteomyelits.54,55
Primary healing in the USA is estimated to cost between US$ 7,000 and US$10,000 per person, but the overall cost of an amputation related to the diabetic foot is estimated between 4.6 and 13.7 billion dollars.56
Costs in Brazil for the treatment of these patients are not known, but due to the notorious deficiencies in our health system, they must be very high, and worse, they sig-nify a major burden for patients and their families.
Pressure sores
Many patients today need a long period of hospitaliza-tion for the treatment of chronic illnesses; typically they are old and have limitations in their normal movements. In this context, we come across pressure wounds, also known as pressure sores which represent a significant chal-lenge for health professionals.57,58
A pressure sore is defined as an area of necrosis in the integument developed as a result of compression of soft tis-sues between an osseous prominence and a hard surface during a sufficiently long period of time to induce local ischemia.59
Patients with pressure sores have extended dependency on their caretakers, higher mortality, and lower quality of life. Pressure sores increase hospitalization time and the overall cost of treatment.60
Accordingly to the NationalPressure Ulcer Advisory Panel, a US agency that coordinates actions for prevention and treatment of pressure sores, prevalence in hospitals in the USA varies from 3% to 14%, increasing to 15% to 25% in nursing homes.61 The incidence reported by Bergstrom
et al62 in home care was 23.9%. In a study performed by São Paulo University at its Hospital Universitário, the in-cidence was 39.5% in surgical units, but higher, 41%, in intensive care units.63
The incidence and prevalence of pressure sores has grown due to the increase in patient age and lower mortal-ity in high-complexmortal-ity surgeries. It is our impression that in São Paulo it has also grown due to a decrease in the qual-ity of care and prevention, especially in intensive care units. Although the problem of diabetic wounds is very ex-tensive but not well quantified in Brazil, the problem caused by excessive pressure sores in bedridden patients should be simpler to evaluate, and measures to identify the potential cases for developing pressure sores should be put in practice, especially because we know that these preventa-tive procedures are most important in the overall care of the patients.
Unfortunately, policies for preventative measures to avoid the development of complex wounds have not been implemented in Brazil, and we are seeing more and more cases in our hospitals, in addition to many recurrences of already treated ulcers.
Hospital das Clínicas comprises for Institutes, the larg-est being the Central Institute, with 920 beds. On average we have 40 patients with pressure sores—about 5%, a fig-ure similar to the international standard. Specific evalua-tion of the severity of those ulcers is currently being done, aided by the use of electronic databases.
Our proposal is to treat such cases as they are identi-fied, but to also take into account that the treatment should more prompt than that in the conventional expectant ori-entation. Surgical treatment is the main option, and includes debridement of necrotic tissues, use of negative pressure64 (vacuum) to better prepare the wound bed, and providing definite closure with stable transplants, mostly local, well-vascularized transplants.65
Prevention must be enforced using well-known scale protocols already reported. The Braden scale is the most popular in our hospitals, and it has been translated into Por-tuguese.66 These protocols are very important for preven-tion of ulcers in higher-risk patients, but even after the clo-sure of the sore, rehabilitation should be instituted in or-der to prevent recurrences.
Chronic venous ulcers
Chronic venous ulcers are considered to be the most common disorder of vascular origin.70,71 The chronic ulcer is caused by chronic venous insufficiency in the lower ex-tremity, but it is frequently aggravated by scarring proc-esses in the surrounding skin and subcutaneous tissues that render treatment of the ulcer by conventional measures slow and that leave tissues prone to recurrences.72
Definite treatment of venous insuffiency is not possi-ble with the presently availapossi-ble technology.73,74,75 Measures to alleviate the insuffiency should be performed when in-dicated; but in order to solve the problem of the chronic wound, a more aggressive surgical protocol should aim to remove the lipodermatosclerotic tissues and to reconstruct the area with tissues that could bring venous channels to alleviate the stasis.76,77,78,79
Venous ulcers are frequent, approximately 0.06% to 1.5% nationally and and internationally.80,81,82 The problem is universally severe, and there is a considerable economic impact.83,84
The etiology and pathophysiology of chronic venous ulcers are still incompletely understood. The most common treatment options include prolonged bed rest, Unna’s boot,85 local wound care,86,87,88 and skin grafting.89,90 We are evalu-ating modern dressings that can be used for this condition and prevent complications.91
The importance of the role of skin grafting resilience and its potential to prevent recurrence is being evaluated, as is that of local and distant flaps used in more severe cases of recalcitrant ulcers after removal of the lipodermatosclerotic tissues.92,93
Vein stripping and perforator ligation valvuloplasty may improve regional venous hemodynamics and are often in-dicated by vascular surgeons, but they do not solve the problem of the wound if there is irreversible scarring due to surrounding lipodermatosclerosis.
For these reasons, we have categorized chronic venous ulcers as complex wounds in order to study dressings and other new ways to treat these wounds as well as the rel-evance of some surgical procedures being developed in the USA, including the use of new local flaps and even micro-surgical transplants to more permanently close the difficult wounds.68
Extensive necrotic gangrene as in Fournier’s syndrome
Fournier’s gangrene is an infectious necrotizing fasciitis of the perineum and genital regions caused by a mixture of aerobic and anaerobic organisms. The mortality rate from this infection ranges from 0% to 67%.94 The outcome is usually fatal if there is no early recognition and extensive surgical debridement upon initial diagnosis.95 This should
be followed by aggressive antibiotic therapy combined with other precautionary and resuscitative measures. It is well know that early aggressive surgical debridement combined with broad-spectrum antibiotic coverage results in de-creased mortality from Fournier’s gangrene and other forms of extensive necrotic fasciitis.
Fournier’s gangrene occurs in male and female patients with genital abscesses, cellulitis, necrotizing fasciitis, and vascular disorders; it is more frequent in males than in fe-males.92
Precautionary measures are important for supporting the patient with Fournier’s gangrene as are urinary and fecal diversions when necessary. Treatment with hyperbaric oxy-gen is still controversial as a complementary treatment to débridements, although some have claimed advantages with its use.96
In the Hospital das Clínicas, São Paulo, aggressive débridements have been used for more than 15 years, and the mortality rate has declined impressively.97,98
However, there are not many articles related to the re-construction after the removal of skin and subcutaneous tis-sue that sometimes are quite extensive, and the wound is usually not amenable to direct closure.
In order to reduce the hospitalization time, we operate to reconstruct these patients promptly, use negative pres-sure (vacuum) for faster preparation of the wound bed, and use skin grafting to close the wound.
Later, reconstruction using flaps for functional (cover-age of testicles) and for aesthetic proposes are done at un-der ambulatory conditions.
Wounds in patients with autoimmune disease or under immunosuppressive drug therapy—vasculitis
Wounds in patients with severe systemic chronic dis-eases seem to have risen in number as hospital care for these diseases has improved. Extensive ulcers that could be considered complex wounds are not frequent, but they may be an important cause for longer hospitalization time and for rising costs of treatment; consequently, they need special consideration.
We have seen a number of those wounds related to autoimmune diseases such as in rheumatoid arthritis and related to immunosuppressive drugs, mostly in transplant patients, and even in less known entities such as pyoderma gangrenosum. The common pathophysiologic link seems to be some form of “vasculitis”, which acts in the periph-eral vessels of the superficial tissues and leads to an in-flammatory process, capillary occlusion, and necrosis of tissues.99
sometimes the surgical debridement can induce new areas of inflammatory process that enlarge the area. Corticosteroids may have a positive effect in controlling the basic problem of vasculitis. Its well-known negative in-fluence on wound healing seems to be less important if a reconstructive procedure like a flap or graft is used.
Recent studies on reconstructive surgery for immunosuppressed organ transplantation patients have shown that no serious deficit of healing was observed, which was also observed with reconstruction after tumor removal and chemo-therapy.100 There is clear evidence that such wounds should not be treated conservatively but rather included in this group of complex wounds and treated accordingly in wound centers. Pyoderma gangrenosum, a cutaneous ulcer with no clear etiology, represents well the difficulties of treating these special wounds caused by vasculitis. It can have different
clinical presentations and is often associated with inflam-matory intestinal disease (55%) and rheumatoid arthritis (37%).101 It can be associated with plastic surgeries includ-ing aesthetic ones, particularly in the breast.102
Our experience is not extensive enough to draw any con-clusion about the best treatment available, but apart of the appropriate medical systemic treatment for the general con-dition, the wound should be treated by removal of necrotic tissue and surrounding tissue of doubtful viability, prepa-ration of the bed, and closure as soon as possible with skin grafting techniques.
Use of adjunctive therapies, such as hyperbaric oxygen therapy, has not proven its value, and it is not presently recommended by our group.
Multidisciplinary care of the patient is essential.103
RESUMO
Ferreira MC, Tuma Jr. P,Carvalho VF, Kamamoto F. Feridas complexas. Clinics. 2006;61(6):571-8.
Ferida complexa é uma nova definição para identificar aquelas feridas crônicas e algumas agudas já bem conhecidas e que desafiam equipes médicas e de enfermagem. São difíceis de serem resolvidas usando tratamentos convencionais e simples curativos. Têm atualmente grande impacto sócio-econômico. Esta revisão procura atrair atenção da comunidade de profissionais de saúde para estas feridas, sugerindo que devam ser tratadas por equipe multidisciplinar em centro hospitalar
especializado. Na maioria dos casos o tratamento cirúrgico deve ser indicado, uma vez que a perda de pele e tecido subcutâneo é extensa, necessitando de reconstrução com enxertos e retalhos. Nova tecnologia, como uso da terapia por pressão negativa foi introduzido. Breves comentários sobre os principais grupos de feridas complexas: pé diabético, úlceras por pressão, úlceras venosas, síndrome de Fournier e vasculites.
UNITERMOS: Feridas complexas. Impacto
sócio-econômico. Tratamento cirúrgico. Enxertos de pele. Retalhos cutâneos.
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