Arq Bras Endocrinol Metab vol.51 número5

Efficacy of the dietary histone deacetylase inhibitor butyrate alone or in combination with vitamin A against proliferation of MCF-7 human breast cancer

(2012) Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo.. This is an open-access

A ÚLTIMA DÉCADA TROUXE importantes avanços no entendimento da patogênese do câncer da tiróide, assim como na conduta que uti- lizamos para o diagnóstico da doença e tratamento

Within thyroid neoplasias, BRAF mutations (V600E) were frequently detected in sporadic PTC (29–83%) (47-50), ranking as the major genetic alter- ation of this type of human

In fact, cAMP inhibits growth in some human thyroid tumoral cell lines (82,83) perhaps involving negative feed back mechanisms such as over expression of PDE4, as described

These findings conclude that histone deacetylase activities, that are inhibited by apicidin, play an essential role in regulation of stage specific gene expression in

Consistent with the result that p21 protein was down-regulated in the gastric cancer tissues [23], we observed that HDAC4 promotes gastric cancer cell proliferation and growth,

Recently, it has been demonstrated that the low levels of viral gene expression induced by a candidate HDACi may be insufficient to cause the death of infected cells by viral