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5 ACKNOWLEDGEMENTS

My first acknowledgment goes to my supervisor, Doutor Ricardo Dinis, a humble and

vibrant professor, whose ideas and encouragement were essential for the development of

this work. It was a real privilege and an honour, to share of his notable scientific

knowledge.

I also express my gratitude to Professor Nuno Lunet, for helping me in the first steps of

this scientific demand.

And, finally, my last words go...

… to my mother, my father, my brothers Vítor and Tiago... pelas memórias, pela presença, pelo sentido de união…

… to Manel… por seres sempre um trator para mim… por me deixares adormecer debaixo da tua manta… por me mostrares os pássaros a cuidar dos bebés… por brincares comigo aos riachos… por me mostrares os avós… por seres o meu dragão preferido… por me mostrares o mundo todos os dias com o teu coração grande… obrigado Manel…

obrigado Rosinha…

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6 TITLE: CAUSES OF DEATH IN HOMELESS POPULATIONS

Running Head: Pinho-Oliveira & Dinis-Oliveira

Author’s name and institutional addresses:

Luís Pinho-Oliveira1,2*, Ricardo Jorge Dinis-Oliveira1,3,4*

1Department of Public Health and Forensic Sciences, and Medical Education, Faculty of

Medicine, University of Porto, Porto, Portugal.

2School of Nursing, University of Minho, Braga, Portugal.

3UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences,

Faculty of Pharmacy, University of Porto, Porto, Portugal.

4IINFACTS - Institute of Research and Advanced Training in Health Sciences and

Technologies, Department of Sciences, University Institute of Health Sciences (IUCS),

CESPU, CRL, Gandra, Portugal.

*Corresponding authors:

Luís Pinho-Oliveira: lpinhooliveira@gmail.com

Ricardo Jorge Dinis-Oliveira: ricardinis@sapo.pt; ricardinis@med.up.pt

Department of Public Health and Forensic Sciences, and Medical Education, Faculty of

Medicine, University of Porto, Porto, Portugal,

Alameda Prof. Hernâni Monteiro,

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7 ABSTRACT

Homeless are vulnerable populations, strongly associated with poverty,

discrimination and health problems. It is an urban and complex phenomenon, estimated

in 100 million people worldwide that results from an interplay between individual and

structural factors, such as family breakdown, mental illness, substance abuse,

unemployment, absence of low-cost housing or incarceration history. Homelessness has

been also described as an important health determinant. Homeless people, particularly

chronic rough sleepers, have an increased risk of premature death, due to cardiovascular,

infectious and alcohol-related disease, unintentional injuries, substance misuse and

suicide. Several obstacles, as lack of awareness of healthcare problems, difficulties in

accessing to medical care and to adhere to therapeutic also contributes to the homeless

poor health status.

A review of mortality causes data on homeless persons was performed aiming to

better understand the extreme burden of disease experienced by these marginalized

populations. This broad understanding of the impact of homelessness on risk of death,

may contribute to influence public health policies, and subsequently to improve the

surveillance of morbidity and mortality in this underprivileged population. Further studies

should evaluate the effectiveness of healthcare and social interventions programs, and

their impact on health status and on social integration of homeless persons.

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8 INTRODUCTION

Homelessness is a complex phenomenon of social discrimination, in modern

societies, that is more than the absence of a safe and adequate place to live 1-6. Strongly

associated with poverty, homelessness is caused by an interaction of individual and

structural factors that progressively interfere with the satisfaction of essential needs as

housing, food, child-care, healthcare or education, with profound social, physical and

mental implications 2,6-10.

Homeless people in comparison with general population, have an increased risk of

physical and mental diseases, as well as an increased risk of mortality and premature

2,4,9,11-18. Despite the increased mortality risks can partly be explained by the by high

exposure to risk factors and high prevalence of morbidity in homeless individuals,

findings from several studies have shown that homelessness itself is an independent risk

factor for death 19,20.

Difficulties in identifying and screen these individuals, as well the social variability

of these populations, poses important governance challenges, namely on diagnosis,

treatment and mostly on prevention of main homeless health problems. The present study

aims to present an overview of whether homelessness characteristics affects morbidity

and mortality causes and rates, in comparison with general population. With this review,

we also intended to identify “turning points” where social interventions programs can

focus on. The understanding of the mortality causes among homeless adult’s populations,

may alert political decisions makers about the impact of social inequalities on health

(9)

9 METHODOLOGY

Search was performed in Medline to identify articles published between January 1,

2008, and December 31, 2018, using the following searching expression: (mortality OR

death) AND (homeless OR roofless OR unsheltered). To be eligible, the studies had to be

written in English, Spanish, or Portuguese, and had to report mortality outcomes in

population-based samples of homeless adults. Systematic reviews and meta-analysis were

also included. Opinion papers and editorials were excluded. Only the studies providing

data for “roofless” and/or “houseless” population, as defined by the European Typology of Homeless and Housing Exclusion, were considered. We excluded articles that limited

the study population to homeless individuals with a specific health condition or homeless

that were recruited exclusively from intensive care or high dependency hospital units.

The articles were first selected by the titles and abstracts. In a second phase, the complete

article was read and the information to be included in this literature review was extracted.

The database review yielded 225 articles, and according to inclusion/exclusion criteria,

29 articles were finally included in the review.

RESULTS

Homeless definition

The homeless are considered “rare”, “hidden” or “hard-to-reach” populations, since generally, it is difficult to identify, sample and interview/evaluate their members,

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10 different approaches to data collection 9,21,22. Homelessness, as a social and non-static

phenomenon, related to economic, political, social and cultural contexts, strongly related

to the housing conventions of a particular community, is conceptualized differently in

most countries 5,6,23,24.

The United Nations Statistical Division classifies homeless people into two

categories, primary homelessness or rooflessness, which includes persons that live in

streets or without a shelter or living quarters, and secondary homelessness, category that

includes persons with no fixed residence, residents of long-term ‘transitional’ shelters and

persons living in private dwellings but reporting ‘no usual address’ on their census form

25. A similar definition is used by the U.S. Department of Health and Human Services,

which considers homeless the subjects without permanent housing who may live on the

streets; stay in a shelter, mission, single room occupancy facilities, abandoned building

or vehicle; or in any other unstable or non-permanent situation 26. In Australia,

homelessness is defined as primary (without regular accommodation), secondary (living

in shelters or temporarily with family or friends or boarding houses) or tertiary (living in

under-standard housing-e.g. boarding houses) 25. In 2005 the European Federation of

National Organizations Working with the Homeless (FEANTSA) had developed a

European Typology of Homelessness and housing exclusion (ETHOS) that have been

used in European Union Countries to classify and screen situations of homelessness and

housing exclusion 6. The ETHOS categories attempt to cover all living situations, namely:

rooflessness (without a shelter of any kind, sleeping rough); houselessness (with a place

to sleep but temporary in institutions or shelter); living in insecure housing (threatened

with severe exclusion due to insecure tenancies, eviction, domestic violence); living in

inadequate housing (in caravans on illegal campsites, in unfit housing, in extreme

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11 family can exercise exclusive possession (physical domain), that meets conditions that

allow privacy and establishment of social relations (social domain), and on which person

has the legal title of occupation (legal domain) 6. Some authors considered that besides

the living place, it is important to take into account the duration time of homelessness,

therefore, three categories of homelessness had been defined: chronic homelessness (an

episode of homelessness lasting more than a year, or four episodes of homelessness in the

previous 2 years), intermittent homelessness (individuals who cycle in and out of

homelessness repeatedly, with episodes of homelessness alternating with housing and

institutional care (jails, hospitals, treatment programs), and crisis or transitional

homelessness (individuals who are only homeless once or twice and for a relatively short

period of time (less than a year) 27.

Sociodemographic characteristics and causes of homelessness

An estimated 100 million people worldwide have no place to live, and more than one

billion have insufficient housing 9,24. More than 400 000 people in the European Union

are homeless on any one night, and more than 600 000 are homeless in the United States

6,9. This numbers may be underestimated, due to the economic and social crisis that has

affected many countries in recent years, as well to the migratory fluxes from the

low-income countries, that may contribute to an increasing number of individuals

experiencing homelessness worldwide 28,29.

Homelessness appears to affect mostly men between 30 and 60 years, unmarried,

(12)

12 The causes of homelessness are complex 5,6,24. This phenomenon has been described

as an interaction of individual and socioeconomic factors, including the presence or

absence of a safety net, which increases the vulnerability to social exclusion 5,6,24. Poverty,

family breakdown, sexual abuse, mental health and substance misuse problems, personal

history of violence and previous institutional history (e.g. prisons, reformatories or

psychiatric hospitals) have been reported as individual factors associated to

homelessness. As structural determinants, unemployment, low salaries, the absence of

low-cost housing, and the lack of institutional support are the most prevalent 1,5-7,24,30,34.

As a result, these people are often associated with illegal or socially sanctioned

activities such as begging, prostitution or theft 13. All these factors became also a blank

wall to the recovery of the work activity, family relationships, health status, and to the

restoration of schedules, routines and social norms with obvious implications to social

inclusion 5.

Health Status

Homeless populations suffer from the same spectrum of medical illness as the general

population, however, homeless individuals, particularly rough sleepers, had an increased

risk of physical and mental diseases, due to the living conditions and risk/unhealthy

behaviours 2,8,9,12,16,35-37.

Environmental insults such as violence, injuries, animal bites, overdose, and heat and

cold exposure complications are described as additional causes to seek healthcare

institutions 16,38-44. All these factors contribute to premature mortality in this population,

(13)

register-13 based cohort study of Danish homeless people revealed more than 5–6 times higher

mortality rates among homeless people than among the general population 48. Studies

conducted in other European countries, Canada, Australia and United States reported

mortality rates 3 to 13 times higher than in general population 42.

Several studies report an age estimated life expectancy of 42 to 52 years for

chronically homeless individuals 8,49,50. Men are more likely to experience unsheltered

homelessness and accounted the majority of homeless deaths, and homeless women have

a higher prevalence of chronic medical conditions and a greater risk of premature

mortality, although the association between gender and mortality in homeless populations

is not consistent 8,9,18,48,49,51.

Lower educational level, history of incarceration, live in unsheltered situations, and

experience of chronic homelessness, are also associated with an increased risk of

premature mortality 8,13,48,52,53. Some studies also report that mortality rates of homeless

individuals living in deprived areas, are higher than those verified in the least deprived

areas, and that this risk is higher in winter and in fall 10,17,42,54,55.

Regarding the common causes of death in homeless populations, as observed in

general population, the social context, the living conditions and the national healthcare

system have an important impact on the morbidity and mortality outcomes. Therefore, in

India, Tunisia or Turkey infectious disease or homicides are the main causes of death

among homeless individuals, while in USA, Canada, Netherlands or France,

cardiovascular disease and overdoses are major causes 10,13,18,49,54,56-58.

Cardiovascular disease

Cardiovascular disease is a frequent cause of morbidity and mortality among the

(14)

14 cardiovascular diseases at younger ages than the general population, namely ischemic

heart and cerebrovascular disease. This can be explained by a high prevalence of

traditional cardiovascular risk factors like hypertension, diabetes and

hypercholesterolemia 13,19,42,59-69. Low socioeconomic status and chronic stress, typically

of homeless populations, are also associated with an increased cardiovascular risk 70.

However, in accordance with majority of studies, this increased risk, is principally

explicated by heavy smoking habits, and a tendency for higher alcohol intake (the

prevalence of smoking habits and alcohol abuse is consistently above 50%), and

indirectly to obstacles on normally access to healthcare services or medications, which

results in a poor controlled hypertension, diabetes, and hypocholesteraemia62,64,66-68. A

high prevalence of mental illness and drugs abuse are also linked to this increased risk.

Data analyses of Toronto homeless people with mental illness revealed a highly elevated

30-years cardiovascular disease risk particularly among individuals with substance

dependence experiencing mental illness 58.

Infectious disease

The proportion of death due to infectious disease is higher among homeless persons

than non-homeless person 10,16,49. Higher frequencies of tuberculosis, an increased risk of

HIV, Hepatitis B or C infection have been reported in these individuals13,16,39,42,54,63,71-77.

A Portuguese study revealed a tuberculosis incidence among homeless persons five times

higher than among the non-homeless, and that almost one-third of these presented HIV

co-infection 75. Malnutrition, immune-compromised host, poor medication adherence,

risk behaviours, as needle sharing, unprotected sex, multiple sexual partners, and

prostitution, are associated with these individuals, and possibly explain the high

(15)

15 rough sleepers, also present a high prevalence of skin lesions and infections, such as

fungal infections, pediculosis or traumatic injuries 16,38,39.

Unintentional injuries

Unintentional injuries are common among homeless populations and are the major

cause of emergency department use 48,78. Traumatic and temperature-related injuries, as

well as medication and illicit substances intoxication, are frequent causes to seek medical

care 44,48,49,56,63,79,80. The results of several studies show that accidental death among

homeless persons are more frequent than those of non-homeless persons, namely due to

hypothermia, and heatstroke, whereas death by traffic accident was lower than

non-homeless persons 57,63,74,81. In a representative sample of homeless deaths database in

France, violent deaths were one of the leading causes of mortality, while homicides

represented 1% of the total of deaths 50.

Psychiatric disease

The prevalence of psychiatric disease in homeless individuals is also strongly higher

than in general population 48. Mental health disorders increase the risk of, and is

exacerbated by homelessness, it is known that approximately half of all homeless

individuals have had mental illnesses at some time in their lives and that the co-existence

of multiple mental problems is also frequent 82. The drug and alcohol dependence and

episodes of depression and schizophrenia are much more frequent among these

individuals than in the general population, in fact, the New York City homeless

surveillance system reports that drug overdose is the leading cause of death among single

adults living in shelters 42,48,64,82-84. A large number of studies highlights that individuals

(16)

16 general psychiatric population 48,58,82,85,86. Regarding the suicide among homeless

persons, several studies reported that this prevalence is lower than the verify on

non-homeless populations, however, data about matter shows proportions of suicide very

distinct, ranging between 1% and 50% 42,46,57,78,87.

Cancer disease

Although the dearth of data on cancer prevalence and mortality among homeless

people, some studies have reported cancer-related death rates being twice as high in

homeless adults as in the general population 42,88-90. Moreover, in result of inappropriate

cancer screening, the little data available indicate a more advanced cancer stage at

diagnosis and higher mortality rates among homeless people compared with the general

population 90,91.

Homeless individuals have a higher risk of developing lung, liver, colon, oral cavity

and cervical cancers, which may be explained by the high prevalence of smoking, alcohol

consumption, B and C hepatitis, and multiple sexual partners 39,64,77,89-92 .

Access to health services

The homeless poor health status may also be justified and/or exacerbated due to lack

of awareness of healthcare problems, difficulties in accessing to medical care and to

adhere to therapeutic prescriptions 7,93,94. As observed among socioeconomically

disadvantaged groups, illiteracy, inability to pay for medical care or medications, little or

no access to health-care system, suboptimal counselling by health-care practitioners, or

merely the absence of a postal address, or identity card, are some of multiple structural

(17)

17 Primary or secondary health prevention programs are often lacking in the homeless

populations, as result the medical treatment of these individuals in mainly focused on the

acute treatment of health problems, and prevention or treatment of chronic diseases plays

a minor role. Therefore, homeless individuals typically attend to emergency department

more often and have longer hospital stays than non-homeless 40,41,80,94-98.

CONCLUSIONS AND FUTURE PERSPECTIVES

This revision emphasizes that roofless and houseless people have much higher

mortality and shorter life expectancy than general population. Cardiovascular,

pulmonary, infectious and alcohol-related diseases, substance misuse, unintentional

injuries, suicides, homicides, and intoxication, seems to be the common causes of death

on these populations. Individual and structural factors, as lower educational level,

unsheltered situations, chronic homelessness or access to national healthcare system, have

also a significant impact on health status and on capacity to recover the homeless

individuals.

The signalling, diagnoses, treatment and follow-up of homeless individuals are

challenging and difficult questions placed to health policies of modern cities. Current

social support based on providing house, food or clothes, have certain benefits but per se

does not reduce health inequity, and cannot provide a survival advantage for the

chronically homeless persons. The evaluation of the effectiveness of current healthcare

and social interventions programs is important to change established policies, practices

and models of care, to improve the health of homeless and reduce mortality trends among

(18)

18 The fact that homeless people encounter numerous physical, social and political

barriers in access to health care is also well established, further studies should focus on

patients’ experiences, perceptions and needs, with the intend to adequate or develop homeless-centered health-care services.

DISCLOSURE STATEMENT

The authors have no relevant affiliations or financial involvement with any organization

or entity with a financial interest in or financial conflict with the subject matter or

materials discussed in the manuscript. This includes employment, consultancies,

honoraria, stock ownership or options, expert testimony, grants or patents received or

pending or royalties. No writing assistance was utilized in the production of this

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63. Suzuki H, Hikiji W, Tanifuji T, Abe N, Fukunaga T. Medicolegal death of homeless persons in Tokyo Metropolis over 12 years (1999-2010). Legal Medicine. 2013;15(3):126-133.

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22 64. Baggett TP, Chang YC, Singer DE, et al. Tobacco-, Alcohol-, and Drug-Attributable Deaths and Their Contribution to Mortality Disparities in a Cohort of Homeless Adults in Boston. American Journal of Public Health. 2015;105(6):1189-1197.

65. Schinka JA, Curtiss G, Leventhal K, Bossarte RM, Lapcevic W, Casey R. Predictors of Mortality in Older Homeless Veterans. Journals of Gerontology Series B-Psychological Sciences and Social Sciences. 2017;72(6):1103-1109.

66. Kubisova D, Adamkova V, Lanska V, Dlouhy P, Rambouskova J, Andel M. Higher prevalence of smoking and lower BMI, waist circumference, cholesterol and triacylglyceride levels in Prague's homeless compared to a majority of the Czech population. BMC Public Health. 2007;7:51.

67. Arnsten JH, Reid K, Bierer M, Rigotti N. Smoking behavior and interest in quitting among homeless smokers. Addict Behav. 2004;29(6):1155-1161.

68. Hwang SW, Bugeja AL. Barriers to appropriate diabetes management among homeless people in Toronto. Cmaj. 2000;163(2):161-165.

69. Bernstein R. Diabetes and hypertension prevalence in homeless adults in the United States: a systematic review and meta-analysis. American journal of public health. 2015;105:e46-60.

70. Albus C. Psychological and social factors in coronary heart disease. Ann Med. 2010;42(7):487-494.

71. Bloss E, Holtz TH, Jereb J, et al. Tuberculosis in indigenous peoples in the U.S., 2003-2008. Public Health Rep. 2011;126(5):677-689.

72. Tan de Bibiana J, Rossi C, Rivest P, et al. Tuberculosis and homelessness in Montreal: a retrospective cohort study. BMC Public Health. 2011;11:833.

73. Beijer U, Wolf A, Fazel S. Prevalence of tuberculosis, hepatitis C virus, and HIV in homeless people: a systematic review and meta-analysis. Lancet Infectious Diseases. 2012;12(11):859-870.

74. Garg A, Behera C, Chopra S, Bhardwaj DN. Mortality among homeless women who remain unclaimed after death: An insight. National Medical Journal of India. 2016;29(4):207-208.

75. Dias M, Gaio R, Sousa P, et al. Tuberculosis among the homeless: should we change the strategy? Int J Tuberc Lung Dis. 2017;21(3):327-332.

76. Kemp PA, Neale J, Robertson M. Homelessness among problem drug users: prevalence, risk factors and trigger events. Health Soc Care Community. 2006;14(4):319-328. 77. Hennessey KA, Bangsberg DR, Weinbaum C, Hahn JA. Hepatitis A seroprevalence and

risk factors among homeless adults in San Francisco: should homelessness be included in the risk-based strategy for vaccination? Public Health Rep. 2009;124(6):813-817. 78. Nilsson SF, Hjorthoj CR, Erlangsen A, Nordentoft M. Suicide and unintentional injury

mortality among homeless people: a Danish nationwide register-based cohort study. European Journal of Public Health. 2014;24(1):50-56.

79. Gama H, Oliveira L, Pereira Mde L, Azevedo A, Lunet N. Use of medicines by homeless people in Porto, Portugal. Cad Saude Publica. 2014;30(1):207-212.

80. Honer WG, Cervantes-Larios A, Jones AA, et al. The Hotel Study - Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons. Canadian Journal of Psychiatry. 2017;62(7):482-492.

81. Romaszko J, Cymes I, Draganska E, Kuchta R, Glinska-Lewczuk K. Mortality among the homeless: Causes and meteorological relationships. Plos One. 2017;12(12):16. 82. Schreiter S, Bermpohl F, Krausz M, et al. The Prevalence of Mental Illness in Homeless

People in Germany A Systematic Review and Meta-analysis. Deutsches Arzteblatt International. 2017;114(40):665-672.

83. Gambatese M, Madsen A, Marder D. Overdose Fatality and Surveillance as a Method for Understanding Mortality Trends in Homeless Populations. Jama Internal Medicine. 2013;173(13):1264-1265.

84. Rayburn RL, Pals H, Wright JD. Death, drugs, and disaster: Mortality among new orleans' homeless. Care Management Journals. 2012;13(1):8-18.

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23 85. Fazel S, Khosla V, Doll H, Geddes J. The prevalence of mental disorders among the homeless in western countries: systematic review and meta-regression analysis. PLoS Med. 2008;5(12):e225.

86. Nilsson SF, Laursen TM, Hjorthoj C, Nordentoft M. Homelessness as a predictor of mortality: an 11-year register-based cohort study. Social Psychiatry and Psychiatric Epidemiology. 2018;53(1):63-75.

87. Schinka JA, Bossarte RM, Curtiss G, Lapcevic WA, Casey RJ. Increased Mortality Among Older Veterans Admitted to VA Homelessness Programs. Psychiatric Services. 2016;67(4):465-468.

88. Lamont DW, Toal FM, Crawford M. Socioeconomic deprivation and health in Glasgow and the west of Scotland--a study of cancer incidence among male residents of hostels for the single homeless. J Epidemiol Community Health. 1997;51(6):668-671.

89. Chau S, Chin M, Chang J, et al. Cancer risk behaviors and screening rates among homeless adults in Los Angeles County. Cancer Epidemiol Biomarkers Prev. 2002;11(5):431-438.

90. Asgary R. Cancer screening in the homeless population. Lancet Oncology. 2018;19(7):E344-E350.

91. Baggett TP, Chang Y, Porneala BC, Bharel M, Singer DE, Rigotti NA. Disparities in Cancer Incidence, Stage, and Mortality at Boston Health Care for the Homeless Program. American Journal of Preventive Medicine. 2015;49(5):694-702.

92. Castillo LS, Williams BA, Hooper SM, Sabatino CP, Weithorn LA, Sudore RL. Lost in Translation: The Unintended Consequences of Advance Directive Law on Clinical Care. Annals of Internal Medicine. 2011;154(2):121-128.

93. Rezansoff SN, Moniruzzaman A, Fazel S, Procyshyn R, Somers JM. Adherence to antipsychotic medication among homeless adults in Vancouver, Canada: a 15-year retrospective cohort study. Soc Psychiatry Psychiatr Epidemiol. 2016;51(12):1623-1632. 94. Romero-Ortuno R, O'Riordan D, Silke B. Profiling the medical admissions of the

homeless. Acute Medicine. 2012;11(4):197-204.

95. Gelberg L, Gallagher TC, Andersen RM, Koegel P. Competing priorities as a barrier to medical care among homeless adults in Los Angeles. Am J Public Health. 1997;87(2):217-220.

96. Linton KF, Shafer MS. Factors Associated with the Health Service Utilization of Unsheltered, Chronically Homeless Adults. Social Work in Public Health. 2014;29(1):73-80.

97. Feral-Pierssens AL, Aubry A, Truchot J, et al. Emergency Care for Homeless Patients: A French Multicenter Cohort Study. American Journal of Public Health. 2016;106(5):893-898.

98. Quilty S, Shannon G, Yao A, Sargent W, McVeigh MF. Factors contributing to frequent attendance to the emergency department of a remote Northern Territory hospital. Medical Journal of Australia. 2016;204(3):111.e1-7.

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ANEXO

AJPH (American Journal of Public Health) Instructions for Authors

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AJPH (American Journal of Public Health)

Instructions for Authors

ISSN: 1541-0048 (electronic); 0090-0036 (print)

Publication Frequency: 12 issues per year plus supplements with external support

Editor-in-Chief: Alfredo Morabia, MD, PhD

TABLE OF CONTENTS

AJPH (American Journal of Public Health) ... 1

Instructions for Authors... 1 TABLE OF CONTENTS ... 1 MANUSCRIPT PREPARATION AND SUBMISSION ... 3 Initial submission ... 3

Formatted submission ... 4

Style ... 4

Manuscript File Formats ... 4 Types of submissions ... 4 Sections ... 8 MANUSCRIPT COMPONENTS ... 16 Title Page ... 16

Abstract ... 17

Abbreviation and acronyms ... 17

Body of the manuscript ... 17

References ... 18

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Figures ... 19

Images and Photos ... 19

Supplemental Files ... 19

Statistics in Tables and Text ... 19

Reproduced Material ... 20

EDITORIAL AND PUBLICATION POLICIES ... 20 Mission... 20 Authorship ... 21

Conflicts of Interest ... 21

Nondiscriminatory Language ... 22

The CONSORT Statement... 23

The TREND Statement ... 23

Embargo Policy ... 23

Publications Resulting from NIH-Funded Research ... 23

Mandates Resulting from White House Office of Science and Technology Policy Directive ... 24

Copyright... 24

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MANUSCRIPT PREPARATION AND SUBMISSION

Initial submission

The initial submission should be clean and complete and must comply with 4 requirements:

a) a blinded title page which includes the title of the manuscript only without any author names or affiliations,

b) numbered pages and lines (in Word, > Page Setup > Line Numbers > Continuous) throughout the text of the manuscript,

c) 1.5 or double spaced with a font size of 12

d) a Cover Letter with concise text (maximum 150 words) that addresses the following three topics:

(1) A description of what the paper adds to current knowledge, in particular with respect to material previously published in AJPH, and if systematic reviews exist on the topic.

(2) The public health importance of the paper.

(3) One sentence summarizing the main message(s) of the paper, which may be used to disseminate the paper on social media. Manuscripts must be submitted online at http://www.editorialmanager.com/ajph.

A first triage done by the Editor-in-Chief and the Senior Deputy Editor identifies manuscripts of sufficient priority. Common causes of insufficient priority are: outdated data (e.g., pre-ACA, data collection completed >3 years before), analysis of surveys not based on the latest data release, results of primarily etiologic interest, small samples, and convenience samples. These are not hard and fast rules. Addressing the 3 questions requested in the cover letter helps us realize when some exception is warranted.

Beyond the triage, manuscripts considered for potential publication in the journal will be submitted to a technical check. Authors will be informed if their manuscripts need reformatting and will be given 7 days to make specific changes. To assure smooth and

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timely processing, ensure that all identifying information has been removed from the submission files (including tables, figures, and supplemental files)—from within the file to the file name itself. This includes author names and initials, IRB information, clinical registration information, acknowledgments and any other details that might potentially unblind the paper to our reviewers. Our online submission system will collect this information via a questionnaire so that the Editors can retrieve the information.

Visit www.ajph.org for online manuscript submission instructions, or submit directly at www.editorialmanager.com/ajph. Questions? Write ajph.submissions@apha.org.

Revised Submissions

Revised manuscripts must be formatted as per AJPH specifications. Citation Style

With the exception of History Essays, all AJPH articles follow the AMA Manual of Style,

10th Edition. Substantive notes and footnotes are not permitted.

Manuscript File Formats

All manuscripts should be submitted in Word document format to

http://www.editorialmanager.com/ajph. Submissions sent to an email address will not be accepted.

Types of submissions

There are 13 submission categories: Research Articles, Brief Articles, Systematic Reviews, Letters and Responses, Editor’s Choice, Opinion Editorials,

Commentaries, Analytic Essays, History Essays, Public Health Practice, Voices, News, and Images. Word totals apply to the main body of the paper and exclude citations, tables, and figures.

Research Articles report the results of original public health research in up to 3500 words in the text, a structured abstract, up to 4 tables & figures combined, and no more than 35 references. The structured abstract must provide the date(s) and location(s) of the study. The text must have an introduction and separate sections for Methods,

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statement below. For non-randomized interventions, see TREND statement below. Research Articles have the highest priority for AJPH.

Brief Articles are not different than a Research paper in terms of quality, importance, priority, etc., but they have up to 1200 words in the main text, a structured (except if justified otherwise in the cover letter) abstract, up to 1 table or figure, and no more than 12 references. A Brief Article is more effective than a full Research paper when the paper is about one specific finding, which can be shown in one table or one figure. In general, AJPH does not publish pilot studies or preliminary results. There may be exceptions, but we are interested in the full study that comes after the piloting. Brief Articles must have an introduction and separate sections for the Methods, Results, Discussion, and Public Health Implications. Some policy-focused Brief Articles that are short essays and do not report study results do not require the latter “Method, Results, Discussion, Public Health Implications” formatted subheadings.

Systematic Reviews, including quantitative and qualitative reviews, have clearly formulated questions and use systematic and explicit methods to identify, select, and critically appraise relevant research and to collect and analyze data from the studies that are included in the reviews. The text word limit is to 4000 words,4 Tables/Figures, and 60 references. Statistical methods (meta-analysis) may or may not be used to analyze and summarize the results of the included studies. To better ensure conformance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, AJPH recommends using these headings—Title, Abstract, Methods, Results, Discussion, Funding—in an expanded research article format, with flexibility when needed for clear assessment and presentation. Systematic reviews should be preferably registered in PROSPERO (http://www.crd.york.ac.uk/PROSPERO), and any changes from the registered protocol reported in the article. References, tables, and figures ought to be pertinent to the topic at hand, but no hard limit will be placed on authors; thus, full compliance with the PRISMA statement can be better ensured. The text, tables, and figures of the accepted systematic review are published online.

However, very big tables may only be made available as supplemental material. Authors whose studies are accepted for publication in the journal will be asked to prepare a 1- page Abridged Version to be published in the print issue. The abridged version comprises: (a) a 400-word Abstract that includes Background, Objectives, Search

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Methods, Selection Criteria, Data Collection and Analysis, Main Results, Author’s Conclusions, and Public Health Implications, (b) a small Table or Figure summarizing a relevant finding of the review, and (c) a 200-word plain-language summary. The Abstract can be 600-words long if the abridged version has no table or figure.

Letters to the Editor are reserved for requiring clarifications on at least one recent AJPH article and are encouraged. They cannot be used to present preliminary results or

develop opinions that are not directly related to a recent AJPH publication. By submitting a Letter to the Editor, the author gives permission for its publication in AJPH. Letters should not duplicate material being published or submitted elsewhere. The editors reserve the right to edit and abridge accepted Letters and to publish Responses. Text is limited to 400 words and 7 references. A single table, figure, or image is permissible. Some letters are published in print and others online only, as per the decision of the Editor-in-Chief.

The Editor’s Choice is commissioned. The text is limited to 600 words with maximum 2 references (but preferably none) and a portrait of the author(s). A conversational and inspirational style is preferred.

Opinion Editorials may be commissioned or reformatted as editorials from submitted papers. They are 1200 words of text with subheadings, 1 small table or figure, and no more than 7 references.

Commentaries are scholarly essays and critical analyses of up to 2500 words in the main text, an unstructured abstract, up to 2 table(s)+figure(s) altogether, and no more than 25 references. They are not long opinion editorials.

Analytic Essays provide critical analyses of public health issues. They have an unstructured abstract, up to 4000 words of text with subheadings, up to 4

table(s)+figure(s), and no more than 40 references. Appropriately acknowledged photographs are encouraged in addition to the tables and figures.

History Essays are reserved for history scholars who use original sources. They have an unstructured abstract, up to 4000 words of text with subheadings, and up to 4 table(s)+figure(s)+ image(s). References (but not extensive notes) must be formatted according to the Chicago Manual of Style, 15th Edition. Authors are asked to cite the indispensable references in the main text and list the important but nonessential ones,

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ordered by topic but unnumbered, in an online appendix made available as an online- only supplemental file for the readers.

Public Health Practice (PHP) Vignettes have a maximum of 1,200 words, withan 80- word abstract, up to 7 references, and up to 2 table(s)+figure(s) altogether that

emphasize the practice of public health and cover the following items, using the following subheadings: (1) Intervention: describe the goals and objectives of the program; (2) Place and Time: provide the geographic location and the years when the program was implemented; (3) Person: define the population subject to the intervention; Purpose: explain the motivation behind the program (5) Implementation: describe how the program was implemented in practice; (6) Evaluation: provide evidence on whether the program worked or not; (7) Adverse Effects: describe whether the implementation of the program had adverse or other unintended consequences; (8) Sustainability: if it is desirable for the practice to continue, describe the factors that indicate why the

intervention is felt to be sustainable; and (9) Public Health Significance: describe the importance of this program for public health, locally and/or more generally.

Voices present brief extracts from the works of public health figures that are republished with an accompanying biographical sketch (up to 1200 words in text, no abstract, 2 figures or images). In the History section, “Voices from the Past” can be up to 2500 words.

News summarizes the content of articles published in other public health journals around the world. They have up to 100-120 words and cover timely global public health topics submitted from a wide range of international (and domestic) editors, practitioners,

investigators, policy makers, field-based practitioners, and students in collaboration with an academic advisor. A single table, figure, or image is permissible and encouraged.

Images: We encourage readers and authors to submit images that can be used as illustrations in the journal or on the AJPH website or social media. Any submitted images must be print quality resolution: 300 dpi minimum with a 150-line screen. Also, AJPH prints evocative, documentary photos on the cover each month. Submissions for cover images must be of print quality resolution 300 dpi minimum with a 150-line screen sized 11x17 or larger. All images and photos should be submitted online as with any other

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Sections

AJPH Forums present critical debates about timely topics. They usually have multiple contributions published in the same or consecutive issues of the Journal. They are formatted as Opinion Editorials. The Editor-in-Chief may encourage an exchange of text between authors prior to acceptance to ensure the debate is useful to the broader public health community. Forum themes are usually announced in an editorial by an Editor.

AJPH Depicting Data is a didactic section discussing ways of summarizing study findings graphically and is edited by Section Editor Roger Vaughan. Authors are

encouraged to propose ways to improve the presentation of articles previously published in the journal. Submissions are formatted as Brief Articles.

AJPH Practice highlights the fieldwork of public health practitioners describing innovative, successful, and cost-effective programs conducted by national, state, and local public health agencies and community-based organizations and groups. Their purpose is to share experiences that others may learn from and replicate. The program preferably should be in operation long enough to permit a rigorous assessment of its impact, factoring in the cost of startup and operation. Authors must include practical experiences and applications for others. Articles are tightly formatted as Public Health Practice Vignettes but can also comprise up to 2 images, especially photographs showing examples of project participants in context; logos; and examples of informational flyers or other educational materials.

AJPH Ethics and Law is edited by Section Editor Mark Rothstein. Papers are usually but not only formatted as Analytic Essays.

AJPH Policy is edited by Associate Editors Colleen Grogan and Daniel M. Fox. Papers usually are formatted as Editorials, Commentaries, Analytic Essays, or Brief Policy Articles.

AJPH Perspective from the Social Sciences, edited by Section Editors Deborah Holtzman and Kenneth McLeroy, features social science scholarship, the work of new disciplines within public health, and critical perspectives of public health problems. Papers are formatted as Analytic Essays.

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AJPH History is edited by Section Editors Theodore Brown and Elizabeth Fee and is devoted to history that bears on contemporary public health. Papers are formatted either as History Essays or as Voices.

AJPH Images of Health consists of provocative pictures, posters, and graphics inspiring readers to ask, What makes an image effective? What images might enhance current or future public health initiatives or materials? How might the power of pictures be

harnessed to improve the public’s health? Section Editors Theodore Brown and Elizabeth Fee edit historical Images of Health columns, and Image Editor Aleisha Kropf edits

contemporary Images of Health columns. Papers are formatted as Editor’s Choice articles but with the specific image(s) in place of the author’s picture. It is possible for

authors to include more than 1 image for this section.

AJPH Global News focuses on news and views from around the world about public health and have a specific format (see p.7). The Section is currently edited by Mila González Dávila, Victor Puac Polanco, and Luis Segura, DrPH students, Mailman School of Public Health, Columbia University, New York, NY\:

AJPH Surveillance and Survey Methods is edited by Associate Editor Denys T. Lau and disseminates information on the design of major surveillance and survey programs and the evolution of methodological novelties that these programs are adopting for public health surveillance objectives to guide actions and policies to improve population health.

Scope: This section publishes peer-reviewed papers on the latest designs and

methodological approaches that major public health surveillance and survey programs —whether new or existing—are testing, developing, and adopting to advance health and healthcare data collection, analysis, interpretation, and dissemination. Surveillance and survey programs can range from gathering data on major life events and disease and wellness progression to tracking health care access, quality, and utilization over time at the local, national, or global level. The intent of this section is to spotlight evolving methods in data collection, analysis, and dissemination for informing the planning, implementation, and evaluation of public health practices and policies.

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data sources:

a) Health surveys on environmental, behavioral, and biological risk factors of populations;

b) Routine health administrative and clinical data, such as those from vital record

systems, provider-based clinical encounter systems including electronic health record information, and payer-based billing and claims systems;

c) Mandatory health reports, such as those on communicable disease cases; and d) Voluntary health reports, such as those on adverse outcomes resulted from drugs,

consumer products, accidents, and notifiable diseases.

This section welcomes the following 3 types of articles: Design Description, Methods Research, and Perspectives.

1) Design Description: Design Description articles describe major design and methodological updates that new or continuing public health surveillance and survey programs have implemented. These articles should describe current approaches employed by established surveillance and survey programs in data collection

procedures, as well as data processing, reporting, and dissemination. These articles should clearly emphasize the public health significance by explaining the impetus and strengths of the design and methodological descriptions and the implications of these updates on population health research, practice, and/or policy. Design Descriptions that address surveillance and survey programs using multiple data sources or different

localities or nations are welcome. Design Description articles should focus on the current design and methodologies used in established surveillance and survey programs. Along with Design Description articles, researchers are encouraged to submit other article types (concurrently or sequentially) if they are interested in, for example, describing an evaluation study that informs the latest design updates of a surveillance or survey

program (e.g., submit a Methods Research article, see p. 13) or describing the historical contexts, policy/research environments, and multiple initiatives taken that have led to the latest development of the established surveillance system (e.g., submit a Perspectives article, see p. 16). In doing so, each article would be reviewed on its merit independently. Depending on the outcome of the peer-review process, one or both of the articles could be published in this section in a coordinated manner. These articles require a structured abstract of up to 180-words with the following four subheadings and brief summary

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within those subheadings: Data System (name, sponsor, purpose); Data

Collection/Processing (data sources and collection mode, population and geographic coverage, sampling approach, and frequency); Data Analysis/Dissemination (data release/accessibility); and Implications (public health significance of the program).

Furthermore, these articles require structured text with a limitation of 3500 words of text and 35 references. There is a limit of 4 tables/figures for this article type. These articles should be written in a narrative format presenting items according to the order of the Checklist of Information for Describing Public Health Surveillance Systems (see the box

on this page). Articles should have the following 4 subheadings: Data System, Data

Collection/Processing, Data Analysis/Dissemination, and Implications. Additional subheadings within these four sections are welcome to help organize the write-up.

Checklist of Information for Describing Public Health Surveillance/Survey Programs

The following checklist of information should be included to the greatest extent possible when describing a public health surveillance/survey program. Depending on the scope of the submission, many of these items should be presented as a narrative in the manuscript text.

Tables and figures may be used to help clarify and complement presentation of information. On occasions, more technical, statistical items may be provided in an appendix or referred elsewhere with proper citations. When providing the following information, survey descriptions, definitions, and outcome metrics should use standards proposed by the American Association for Public Opinion Research’s 2015 8th Edition Standard Definitions: Final Dispositions of Case Codes and Outcome Rates for Surveys

(https://www.aapor.org/AAPOR_Main/media/MainSiteFiles/Standard- Definitions2015_8thEd.pdf).

1) DATA SYSTEM

A. Name/sponsor(s): What is the full name of the surveillance/survey program? What is the full name of the organization(s) sponsoring and conducting the program?

B. Purpose: What is the purpose of the surveillance/survey program and what is it designed to do?

C. Public health significance: What is the surveillance/survey program’s public health significance? How can the program address a public health priority?

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2) DATA COLLECTION/PROCESSING

A. Data sources and collection mode: How are the data in the surveillance/survey program collected and from what sources? For example, are the data collected from in-person, telephone, web-based, or mail surveys; physical examinations and laboratory testing; manual review of patient medical chart or extraction of electronic medical and administrative billing records; state vital registrations; mandatory or volunteer case reporting from care providers? What are the procedures for collecting the data and what developmental work such as pretesting, if any, has been completed on these adopted methods? Are the data an integration of multiple systems and if so, what are the data sources?

B. Ethical procedures: What informed consent procedures were followed or what institutional ethical review board approvals have been obtained, if any, to collect data in the surveillance/survey program?

C. Population(s) and geographic coverage: What population(s) or subpopulation(s) does the surveillance/survey program include/exclude and in what geographic areas (coverage and granularity)? If the program collects data on sampled cases, what is the sample frame, sampling technique, and target respondents for demonstrating how representative the sample is to the population of inference? What subpopulations, if any, are oversampled or followed up over time?

D. Unit of data collection and sample size: What is the unit of data collection in the surveillance/survey program, how complete are the data according to the intended coverage, and what is the total number of cases over a time period? If the program collects data on sampled cases, what is the target sample size and response rate (overall and multistage, if applicable)? How are the nonresponse cases handled to address generalizability? E. Surveillance design and frequency of data collection: How are the data collected in the

surveillance/survey program and how often? For example, are the data collected cross- sectionally or longitudinally; in an overlapping panel design; retrospectively or prospectively in real-time? Are they data collected continuously, annually, biennially, etc?

F. Key data elements and data quality/editing: What are some of the key data elements of interest collected in the surveillance/survey program? What is the data quality of the program in regards to sensitivity, specificity, and reliability? Are definitions used to identify cases or to define variables based on accepted standards? What are the patterns of missing data and what imputations if any are used? What masking techniques or other data

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editing/processing have taken place for quality control purposes or managing disclosure risks?

3) DATA ANALYSIS/DISSEMINATION

A. Interpretation issues: What interpretation issues should be highlighted that may be associated with the way data are collected, or definitional, procedural, or instrument-related changes over time in the surveillance/survey program?

B. Linkage ability: To what other data sources, if any, can the data in the surveillance/ survey program be linked for analytical purposes? What are the restrictions and procedures to follow to link these multiple data systems?

C. Data release/accessibility: What years of data are collected, available currently for analysis, and planned for future release if any? How are the data in the surveillance/survey program released and can be accessed? For example, what is the website and/or address where the data can be obtained? What key data elements are publicly available, released under restricted conditions, or withheld by sponsoring organization(s)? What is the fee schedule, if any, for accessing the data?

D. Key references/other information: What published methodological reports can be cited on the surveillance/survey program? What other relevant information, especially on the data limitation and quality on identifying cases, may help improve the understanding of the program?

4) IMPLICATIONS

A. Impact: What is the evidence on impact that the surveillance/survey program has on public health research, policy, and practice? For example, does the program detect diseases, outbreaks, injuries, or adverse exposures to permit accurate diagnosis or identification, and effective prevention or

treatment programs? Does the program promote research by providing estimates and detecting trends on morbidity and mortality as well as identifying their associated factors?

2) Methods Research: Methods Research articles report testing of novel methodologies that established public health surveillance/survey programs are evaluating to inform significant design updates that have been implemented in these programs. Different from Design Descriptions articles that describe the surveillance/survey program in detail,

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Methods Research articles focus on the scientific testing and findings of new methods that have led to design updates in the surveillance/survey program. Methods research, for example, can include experimental tests of new surveillance methods, evaluations of new data collection or analytical techniques, and empirical studies that contribute to survey statistical theory. These articles should clearly emphasize the public health significance by explaining what the impetus and rationale are for the methods research and how the findings are used to inform the established surveillance/survey program and advance the overall field. Methods Research articles comparing multiple surveillance data sources or different localities or countries are welcome. Because Methods Research articles would need to describe an established public health surveillance/ survey program on which the testing is based, researchers are encouraged to submit the following 2 types of article to this section for publication consideration:

a) Design Description article on the public health surveillance/survey program (see p. 10); and

b) Methods Research article that describes the testing of methodologies that eventually inform the development and design updates to the public health surveillance/survey program.

In doing so, each article would be reviewed on its merit independently. Depending on the outcome of the peer-review process, 1 or both of the articles could be published in this section in a coordinated manner. If the researchers choose not to submit a separate Design Description article on the public health surveillance/survey program, the Methods Research article should provide detailed description of the surveillance/survey program according the Checklist of Information for Describing Public Health Surveillance Systems (see the box on p. 11) in the body of the article. Methods Research articles require a structured abstract of 180 words or fewer and are structured with a limitation of 3500 words of text and 35 references. There is a limit of 4 tables/figures for this article type. The structure of these articles should follow the same format as AJPH’s instructions on Research Articles. The abstract should employ 4 headings: Objectives, Methods, Results, and Conclusions. Policy Implication is optional for the abstract. These articles should have the following 5 separated sections: Instruction, Methods, Results,

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development in the various countries of research in the field of public health, as a necessary support. to the health activities that are being conducted by

In practice, it is soretimes possible to do no more than limit the evaluation to certain phases, There a re no reliable means for evaluating the results of certain

'Years of potential life lost for persons between I year and 65 years old at the time of death are derived from the number of deaths in each age category as reported

Purpose: to identify and analyze the characteristics of academic research under the rubric Case Report. Methods: we conducted an empirical-analytic research of papers published

For these reasons, the aim of this review is to report on some characteristics, preparation methods, applications and especially analyze recent research available in the literature

What is advocated here is thus pertinent to institutions, such as public health departments or university programs, that are home to lines of research inhabiting both worlds

Monthly publication led to significant growth in the total number of articles published per year, thus better serving the Brazilian public health research community.. One