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In vitro expanded stem cells from the developing retina fail to generate photoreceptors but differentiate into myelinating oligodendrocytes.

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Figure 1. Immunocytochemistry, RT-PCR and Q-PCR analyses of neonatal ‘RSCs’ during in vitro cultivation
Figure 2. Differentiation of ‘RSCs’ in vitro . Following differentiation in 1% newborn calf serum expanded ‘RSCs’ showed immunoreactivity for the pan-neuronal markers b-III-tubulin (A, red) and MAP2 (B, red) or the glial marker GFAP (A, green)
Figure 5. Transplantation of ‘RSCs’ into adult mouse retina. Immunohistochemical analysis on adult wild-type retinas transplanted with GFP- GFP-positive ‘RSCs’ (green in A, B, C, and D) revealed that the majority of integrated donor cells expressed GFAP, i
Figure 6. Oligodendrocyte differentiation of ‘RSCs’ in vitro . Whereas primary cells isolated at E14.5 from different regions of the CNS, i.e.
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