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Synthesis and evaluation of 5-substituted (thio)barbiturates as proteasome inhibitors for cancer therapy

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Academic year: 2021

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Figure 1.1: Structure and components of the 26S proteasome and the location of the active sites in the  20S core
Figure 1.2: Ubiquitin-mediated protein degradation. (from Kaiser et al. 2005) 31
Figure 1.3: Proteasome inhibitors approved for the clinical use.
Figure 1.5: peptide vinyl sulfone inhibitors ZLVS and NLVS.
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