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FIGUrE 1.  Flowchart for the systematic literature search and results of the selection process SLR: systematic literature review
FIGUrE 2.  MTX dose adjustment according to creatinine clearance. (Adapted from Kintzel PE and Dorr RT, “Anticancer Drug Renal Toxicity and Elimination: Dosing Guidelines for Altered Renal Function”, Cancer Treat Rev, 1995, 21(1):33-64)

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