Anti-Trypanosoma cruzi activity
Evaluation of in vitro anti-Trypanosoma cruzi activity of medications benznidazole, amiodarone hydrochloride, and their combination
... peak of parasitaemia), the mice were euthanized, and blood was obtained by cardiac puncture. The plasma was separated. The red blood cell concentrate that is routinely neglected was used for the in vitro proliferation of ...
5
BenznidazoleItraconazole Combination Treatment Enhances Anti- Trypanosoma cruzi Activity in Experimental Chagas Disease
... To evaluate the efficacy of early treatment in preventing the development of chronic lesions in mice infected with the Y strain, a quantitative analysis of the inflammation and fibrotic area in the cardiac muscle tissue ...
12
Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal
... that activity were not described ...the anti-T. cruzi activity of organic extracts made from 31 halophyte species abundant in the southern area of ...
7
In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of a Novel Nitro-derivative
... The mechanism of action of 5NO 2 TM is not com- pletely known, however a similar one to other nitro-de- rivatives should be accounted for. Nitroderivatives have been reported to have different mechanisms of action, that ...
5
REPOSITORIO INSTITUCIONAL DA UFOP: Ravuconazole self-emulsifying delivery system : in vitro activity against Trypanosoma cruzi amastigotes and in vivo toxicity.
... in Trypanosoma cruzi-infected mice was safe during the 20-day ...The anti-T. cruzi activity of free ravuconazole, ravuconazole–SEDDS and each excipient were evaluated in vitro at ...
15
Purification and Partial Characterization of Trypanosoma cruzi Triosephosphate Isomerase
... T. cruzi epimastigote forms by combining phenyl-Sepharose, CM-Sepharose and gel filtra- tion high performance liquid ...T. cruzi was fractionated by phenyl-Sepharose column us- ing an ammonium sulfate ...
6
High throughput screening for anti-Trypanosoma cruzi drug discovery.
... T. cruzi molecular biology and the development of plasmids and efficient parasite transfection protocols [37] permitted the construction of reliable and robust transgenic ...T. cruzi parasites of multiple ...
6
Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi
... for anti- microbial and anticancer ...religation activity of the enzymes (Pommier et al. 2010). In addition, if anti-cancer drugs targeting topoisomerases prove effective in killing ...
5
Substâncias da natureza com atividade anti-Trypanosoma cruzi.
... with anti-Trypanossoma cruzi ...by Trypanosoma cruzi, affects 16-18 million people in the ...T. cruzi from blood, that are more effective and that do not affect red blood cells is the ...
11
Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi
... trypanocidal activity against trypomastigotes of ...trypanocidal activity of two diterpenoids (Azorellanol and mulin-11,13 -dien-20-oico acid) against extracellular amastigotes of the CL Brener clone, ...
6
Looking for combination of benznidazole and Trypanosoma cruzi- triosephosphate isomerase inhibitors for Chagas disease treatment
... Bnz and the combination of 3 and Bnz. For that, male BALB/c infected mice, with CL Brener clone, DTU Tc VI, were orally administered during 15 days with the combinations. In both cases the same dose of drug com- bination ...
8
In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)
... trypanocidal activity exhibited by the essential oil from ...antiparasitic activity (Escobar et ...trypanocidal activity (Sartorelli et ...antiparasitic activity reported by the literature ...
9
Antitrypanosomal acetylene fatty acid derivatives from the seeds of porcelia macrocarpa (annonaceae)
... Dried and ground seeds of unripe fruits (156 g) were extracted with n-hexane (3 × 400 mL). Hexane solutions were then combined and the solvent was eliminated under vacuum, yielding 60 g of an orange oil. Part of this ...
13
J. Braz. Chem. Soc. vol.13 número2
... vitro activity against trypomastigote forms of Trypanosoma cruzi, showing, however, lytic activity on blood erythrocytes, as a side ...therapeutic activity and without the side ...
7
Daniel Sol Sol de Medeiros [1],[2],[3] , Ana Fidelina Gómez Garay [2],[3],[4], Jorge Alfonso Ruiz Diaz [2],[3],[4] , Maria Celeste Vega Gómez [4], Carolina Bioni Garcia Teles [1],[2],[5],[6] and Leonardo de Azevedo Calderon
... limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal ...T. cruzi, ...
5
Rev. bras. farmacogn. vol.18 número2
... the activity of prenyloxycoumarin 8 against T. cruzi blood trypomastigotes, infected mouse blood was incubated in vitro at 4 ºC for 48 h with 250 μg/mL and 500 μg/ mL of the ...
6
Rev. Bras. Cienc. Farm. vol.42 número1
... of Trypanosoma cruzi, amastigote-like forms of Leishmania amazonensis and twenty strains of microorganisms including Gram-positive and Gram-negative bacteria and yeasts were utilized in the ...
8
Influence of Ecto-Nucleoside Triphosphate Diphosphohydrolase Activity on Trypanosoma cruzi
... ecto-nucleotidase activity and infectivity capacity, we started a continuous in vitro cultivation of Y trypomastigotes in VERO cell cultures and analyzed Ecto-ATPDase ...ecto-ATPase activity ranged from ...
11
Freqüência do parasitismo encefálico em camundongos experimentalmente inoculados com diferentes cepas de Trypanosoma cruzi.
... FREQÜÊNCIA DO PARASITISMO ENCEFÁLICO EM CAMUNDONGOS EXPERIMENTALMENTE INOCULADOS COM DIFERENTES CEPAS. DE TRYPANOSOMA CRUZI[r] ...
4
Transferência horizontal de seqüências de minicírculos de kDNA de Trypanosoma cruzi para o genoma de chagásicos e herança vertical das mutações
... VGT was demonstrated in 45% of Chagas patients’ descendents. The analyses of the juxtaposition regions of the kDNA to the human genome revealed that the minicircle sequences integrate preferentially into ...
160