Bile-acid
Reactivity of human fetal and adult immortalized hepatocytes to potentially toxic bilirubin and bile acid species
... and bile acid species treatment in our study ...that bile acids induce an almost instantaneous oxidative stress response, which triggers JNK1/2 activation and may in turn activate ...
99
Effect of Roux-en-Y gastric bypass surgery on bile acid metabolism in normal and obese diabetic rats.
... plasma bile acid (BA) levels ...with bile acid sequestrants or inhibitors of apical sodium dependent bile acid transporter (ASBT, Slc10a2), which reduce plasma BAs and increase ...
17
Identification of miR-26a as a target gene of bile acid receptor GPBAR-1/TGR5.
... GPBAR1/TGR5 is a G protein–coupled receptor of bile acids. TGR5 is known to regulate the BA homeostasis and energy metabolism. Recent studies highlight an important role of TGR5 in alleviating obesity and ...
12
Metformin protects rat hepatocytes against bile acid-induced apoptosis.
... Subsequently, we studied whether the reduction in apoptotic cell death by metformin results in a shift towards necrotic cell Figure 3. Metformin protects primary hepatocytes against apoptosis when added after GCDCA, but ...
10
GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells.
... protein–coupled bile acid (BA) receptor, which displays varied levels of expression in different tissues ...lithocholic acid (LCA) and deoxycholic acid (DCA), are potent endogenous ligands of ...
10
Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver.
... into bile, stored in the gall blad- der, and post-prandially released to facilitate dietary lipid and fat-soluble vitamin ...dependent bile acid transporter (Asbt) [6], the expression of which is ...
18
Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis.
... classic bile acid synthesis pathway and Cyp7b1 is used in the alternative pathway of bile acid synthesis ...Thus, bile acid synthesis is decreased in the ...liver bile ...
7
Noninvasive methods to determine the critical micelle concentration of some bile acid salts
... All potentiometric measurements were carried out with a Crison 2002 pH meter and 2031 buret controlled by a personal computer which was also used for data manipulation. The electrode assembly was made up of an Orion ...
10
The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis.
... TNBS and DSS colitis were induced as described [11]. Five days after TNBS, 1.5 mg/mouse, or DSS, 5% in drinking water, administration, mice were sacrificed, colons were removed and immediately frozen in liquid nitrogen ...
11
Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain.
... To understand whether our discoveries are limited to CNS or can be observed also in other tissues, we decided to compare variations in the expression levels of caspases and of cholesterol genes in human liver, an ...
17
Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.
... indicating a bile acid-dependent regulation of TG synthesis in the liver via lipin-2. This study is, to our knowledge, the first to show a direct link between lipin-2 down-regulation and bile acids. ...
9
Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice.
... both bile acid (cholic acid) and INT-777 has been previously reported to result in weight loss in diet-induced obese (DIO) mice with chronic administration ...
17
Comparative genome analysis of Megasphaera sp. reveals niche specialization and its potential role in the human gut.
... of bile. The bacteria that are sensitive to bile are not capable of survival in the ...The bile tolerance test suggested that all the three isolates in this study can tolerate ...0.3% bile. ...
13
Rev. bras. farmacogn. vol.18 número1
... of bile fl ow and of the bile acids out ...that bile secretion is mainly induced through two different mechanisms defi ned as bile acid-dependent and bile acid-independent ...
5
Muricholic acids inhibit Clostridium difficile spore germination and growth.
... particular bile acids may inhibit ...the bile acid/muricholic acid synthesis pathway would allow the determination of which bile acids are relevant for stimulating or inhibiting in vivo ...
7
Rev. bras. farmacogn. vol.20 número1
... ABSTRACT: The present study was undertaken to evaluate the eficacy of freeze dried extract of Clerodendron glandulosum Coleb., Verbenaceae, leaves (FECG) on alteration in lipid and cholesterol metabolism in high fat diet ...
7
Bile: Kullanım Değerleri <br> Even: Use-Values
... kızında bile kusur olur” -önvarsayım: Kadı kızının kusursuz olması beklenir-; “Dünya Sultan Süleyman‟a bile kalmamıĢ”); çoğu zaman da sadece sözcelem öznesi için geçerli olan “en düĢünülmeyecek durum, olgu ...
18
Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis.
... Figure 10. Homology modeling based three-dimensional structure of FadD13. A. Overall structure of FadD13 model. The FadD13 model was generated by using the SWISS-MODEL server based on the template with pdb id: 2QVY. A ...
15
Evidence for prehistoric origins of Egyptian mummification in late Neolithic burials.
... pimaric acid, sandaracopimaric acid, isopimaric acid, 6-dehydrodehydroabietic acid, dehydroabietic acid, abietic acid, 15-dehydrodehydroabietic acid, ...
13
Pesquisa de bactérias, fungos, protozoários e cristais em bile vesicular.
... e bile de cadáveres e 23 de portadores de colecistopatia que se subm eteram à cirurgia; procuraram averiguar o per centual de positividade para bactérias, fungos, cristais e cálculos, para uma possível avaliação ...
4