CD4+ T Cells
Exchange of cytosolic content between T cells and tumor cells activates CD4 T cells and impedes cancer growth.
... tumor cells by visualization of the contact ...the T cell into the tumor cell which emerged at the highest magnification to be enabled by gaps in the cell membrane of both partners (Figure 1E ...L23 ...
14
Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells.
... memory CD4 T-cells that produced IFN-γ, IL-2, TNF-α or MIP-1β fol- lowing 6 hour stimulation with PPD or CMV grade 2 antigen were classified as PPD-specific or CMV-specific CD4 ...
15
Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.
... in CD4+ T cells. CD4+ and CD8+ T cells developed normally in Capn4 F/F :CD4-CRE mice and had severely diminished expression of Calpain 1 and 2, diminished talin ...
9
Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells.
... promote CD4 CTL activity [27]. Our lab has made use of T cell receptor (TCR) transgenic (tg) CD4 T cells specific for a single peptide to allow for the delineation of the factors ...
12
HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation.
... T cells. Nef modulation of DC-SIGN and CD4 expression was observed, though levels of DC-SIGN upregulation were limited in lentiviral vector transduced ...and CD4 expression in a largely ...
10
Rapid reactivation of extralymphoid CD4 T cells during secondary infection.
... memory T cells of a highly activated ...tissue-memory T cells suggests these cells may perform a ‘sentinel’ function in the ...extralymphoid CD4+ T cells can ...
10
Destruction of lymphoid organ architecture and hepatitis caused by CD4+ T cells.
... T cells were infected with ...(T cells; green), B220 (B cells; red), Laminin (blue), or CD35 (FDCs; green), gp38 (FRCs; red), Desmin (stromal cells, blue), or BP-3 (follicular ...
13
SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
... nTreg cells in the presence of exogenous IL-2 results in their survival and ...Treg cells have no suppressive function in the presence of anti- receptor agonistic Abs or ...Teff cells renders them ...
8
Granulysin-expressing CD4+ T cells as candidate immune marker for tuberculosis during childhood and adolescence.
... period, cells were fixed and permeabilized using BD cytofix/cytoperm TM (BD Biosciences) according to manufacturer’s ...instructions. Cells were then washed twice in BD perm/wash TM solution (BD ...
10
Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells.
... of cells for cytokine measurements and/or for the redirected cytotoxicity assay: control Ab (mouse IgG) was purchased from Santa Cruz; anti-CD3 Ab (OKT3) was purchased from Imgenex; anti-CD94 Ab (DX22) and ...
14
Systemic BCG immunization induces persistent lung mucosal multifunctional CD4 T(EM) cells which expand following virulent mycobacterial challenge.
... producing CD4 T cells in protection against tuberculosis infection, we assessed the frequency of antigen-specific IFN-c cells by ELISPOT during the course of ...(SFU)/million cells ...
12
BAFF promotes regulatory T-cell apoptosis and blocks cytokine production by activating B cells in primary biliary cirrhosis
... mononuclear cells (PBMCs) were isolated on Ficoll gradients (GE Healthcare, ...n t i - C D 2 5 , a n d P E - c o n j u g a t e d a n t i - F O X P 3 (eBiosciences, USA), according to the ...
7
4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4+CD25+FoxP3+ T Regulatory Cell Suppression.
... to T cell activation, acquisition of effector function, and long-term memory, more so for CD8 + than for CD4 + T cells ...NK cells, neutrophils, DCs, and mono- cytes/macrophages ...
13
Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection.
... that CD4+ T cells have a pivotal role and crosstalk with different subsets of DC, our findings are in line with other studies suggesting that DC subsets affect Th17 differentiation and plasticity in ...
14
Immunopathology in ocular toxoplasmosis: facts and clues
... of T(H)-17 cells. IL-27 thus appears to act directly on effector T- cells to suppress the IL-6 and TGF-β-induced differen- tiation of the T(H)-17 ...the CD4(+) ...
10
A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.
... in CD4 stabilization at plasma membrane, p56 Lck is also central for HIV-1 Nef activity at tuning the activation levels in infected CD4+ T cells and extending their life- span during viral ...
21
HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).
... by T-cell activation. CD4 + T cells from HBZ-Tg secreted higher level of IL-10 by stimulation of anti-CD3 and anti-CD28 antibodies compared with those of non-Tg mice (Fig ...+ CD4 + ...
22
Lymphocyte Differentiation and Effector Functions
... B cells may respond to ligands of TLR besides BCR, and T cells have receptors for costimulatory molecules presented by antigen presenting cells, which are expressed upon proinflammatory ...
4
Altered immune responses in rhesus macaques co-infected with SIV and Plasmodium cynomolgi: an animal model for coincident AIDS and relapsing malaria.
... characterize T cell subset dynamics during both infections, naı¨ve (CD95-CD28+), central memory (CD95+ CD28+), and activated memory (CD45RA2CCR5+) CD4+ T cells were quantified by four-color ...
10
Gag-specific CD4+ T-cell frequency is inversely correlated with proviral load and directly correlated with immune activation in infection with human immunodeficiency virus type 2 (HIV-2) but not HIV-1
... for CD4 within 24 h of cell fixation as previously described ...cytokine-positive CD4 ⫹ T cells within total CD4 ⫹ T cells after background subtraction (anti- CD28 ...
5