Conformational changes
Conformational proofreading: the impact of conformational changes on the specificity of molecular recognition.
... for conformational changes upon binding between the native and the bound states of many biomolecules, for example in enzyme-substrate [4], antibody- antigen [5–9] and other protein-protein complexes ...with ...
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Conformational changes in a hyperthermostable glycoside hydrolase: enzymatic activity is a consequence of the loop dynamics and protonation balance
... that conformational changes caused by pH variation did not change the core of the TpManGH5, which means that only the above mentioned loop region presents high degree of ...that conformational ...
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pH-dependent conformational changes in the HCV NS3 protein modulate its ATPase and helicase activities.
... pH-dependent conformational changes that cause NS3 to adopt a less stable and more open conformation with evident increases in hydrophobic clefts ...dependent conformational changes are ...
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Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helices.
... From a more general perspective, this study reveals the interplay of membrane interactions and conformational changes involved in transmembrane signaling by receptors and associated proteins and/or domains. ...
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Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding.
... Based on the detail structural analysis of POPs, we suggest that dynamic conformational changes are associated with the ligand binding in plant and animal POPs. Loosening of interactions between b-propeller ...
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Protein conformational changes in the bacteriorhodopsin photocycle: comparison of findings from electron and X-ray crystallographic analyses.
... large conformational changes but these are located in the EF loop and in the cytoplasmic ends of helices F and G; these are exactly in correspondence to the missing parts in 1C8S ...
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Structural basis and kinetics of force-induced conformational changes of an αA domain-containing integrin.
... movements of the MIDAS metal ion were observed (Figure S1B), nor were their coordinating residues (Figure S1C–F). Nevertheless, Figure 1. Conformational changes of aA domain-containing integrin. (A, B) ...
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Correction: Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains.
... dependent conformational changes in the C-terminus of the T-ag OBDs could regulate interface formation within T-ag ...dependent conformational changes in the F257/258 containing C-termini are ...
2
Decipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.
... the conformational sampling and nucleotide-dependent conformations of biomolecular machines ...spontaneous conformational changes at the atomic level [26] and to translate the conformational ...
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Allosteric communication in myosin V: from small conformational changes to large directed movements.
... Some insights concerning how myosin functions have been obtained by comparing sets of structures that are thought to represent various stages in the cycle. These analyses are based on the implicit assumption that an ...
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Ligand photo-isomerization triggers conformational changes in iGluR2 ligand binding domain.
... The photo-switching simulations adopted a protocol used previously on this system, where a short biasing potential simulates the ligand photo-reaction and the following slow protein response can then be monitored in MD ...
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Conformational changes in acetylcholine binding protein investigated by temperature accelerated molecular dynamics.
... Despite the large number of studies available on nicotinic acetylcholine receptors, a complete account of the mechanistic aspects of their gating transition in response to ligand binding still remains elusive. As a first ...
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Understanding the conformational changes and molecular structure of furoyl thioureas upon substitution.
... Theoretical Conformational and Natural Bond Orbital Analysis A rich conformational landscape can be anticipated for the studied ...relevant conformational changes are expected by differences ...
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CONFORMATIONAL-CHANGES AT MEMBRANES of TARGET-CELLS INDUCED BY PEPTIDE HORMONE ANGIOTENSIN - SPIN LABEL STUDY
... However, the effect was consistently and significantly more pronounced with AI1 (table 1). This, and the tachyphyllactic behaviour, suggest that a signi- ficant part[r] ...
4
Cyclic nucleotide regulation in a potassium channel: ligand selectivity and conformational change
... Fig. S9. Time-lapse AFM topographs of mutant R348A MlotiK1 recorded in the absence and presence of cAMP. (a) Mutant MlotiK1 channels recorded in cAMP-free buffer solution. After an incubation time of ∼3 h all channels ...
152
Structural and conformational effects of metal binding to the S100B cytokine
... intra and extracellular function. It is involved in several pathological processes in which metal homeostasis is imbalanced, such as AD and ALS, which account for a modified protein function. Metal binding to S100B ...
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The powerful high pressure tool for protein conformational studies
... In order to validate our proposed mech- anism of human Q26 ataxin-3 unfolding and aggregation for pathogenic forms of ataxin- 3, we used as a model the human Q36 variant which forms amyloid fibrils at high temper- ature ...
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Biological and conformational evaluation of angiotensin II lactam bridge containing analogues
... equivalent conformational changes (data not ...the conformational behavior of the analogues with that observed for the native AII, which is shown by NMR to possess a bend that is stabilized by ...
7
Switch region for pathogenic structural change in conformational disease and its prediction.
... structural changes, misfolding occurs in regions important for the stability of the native ...structural changes is ...triggering conformational diseases (CDs) and is the first that can predict ...
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Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.
... acquired changes that switch restriction specificity between different lentiviral lineages, resulting in species-specific alleles that target different ...propagates conformational changes into the ...
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