Effector T cells
Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus
... TREG cells but are only expressed after activation in other T cell ...cytotoxic T lymphocyte antigen 4 (CTLA-4), whose con- stitutive expression in TREG cells was shown to be under the control ...
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A convenient model of severe, high incidence autoimmune gastritis caused by polyclonal effector T cells and without perturbation of regulatory T cells.
... Treg cells was detected in the paragastric lymph node of gastritic mice, and a significantly higher percentage of Treg cells was found in the stomach of gastritic mice compared to normal mice, Treg ...
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CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA.
... BTLA-deficient T cells show increased proliferation [25,27,28], and BTLA-knockout mice have enhanced susceptibility to autoimmune disease and increased inflammatory responses ...expressing T ...
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Invited Lectures
... CD4+ T cells differentiate in dif- ferent subsets of effector T helper (Th) cells cha- racterized by specific cytokine profile and specia- lized effector ...Th cells are ...
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Advances in understanding immunity to Toxoplasma gondii
... accessory cells and T cells interact to coordinate a protective immune response and, subsequently, how effector T cells interact with ...infected cells to control parasite ...
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Cord blood derived CD4+ CD25(high) T cells become functional regulatory T cells upon antigen encounter.
... high T cells) possess inhibitory potential [21]. Treg cells possess a T cell receptor (TCR) repertoire as broad as CD25 2 T cells [22] and it is known that Tregs become ...
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T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
... 1 effector T cells, in particular master transcription regulators T-bet and ...In T cells, T-bet and Eomes are regulated by cytokines with divergent functions and ...
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Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage.
... T cells [6–10]. Initiation of the diabetogenic response involves T cell recognition of a limited number of b cell ...cell-specific effector T cells (Teff) ...a T cell ...
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Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.
... Although effector T cells other than Tregs express CTLA4 after stimulation [36], FoxP3 + cell- restricted deletion of Ctla4 leads to a sub-lethal multifocal inflammatory disorder similar to that ...
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miRNA profiling of naive, effector and memory CD8 T cells.
... antigen-induced T cell differentiation, the role of miRNAs in the process is not ...naı¨ve, effector and memory CD8+ T cells using 3 different methods-small RNA cloning, miRNA microarray ...
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Exchange of cytosolic content between T cells and tumor cells activates CD4 T cells and impedes cancer growth.
... of cells co-cultured was difficult to evaluate since the number of adherent cells could hardly be ...of cells used for ...and cells were air-dried over ...min. Cells were embedded using ...
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Targeting c-MYC with T-cells.
... splenic T-cells were ...between cells restimulated with c-MYC protein or peptide pool, whereas T-cells from naïve or OVA- immunized control mice revealed only background secretion ...
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Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response.
... influenza-specific T cells would be enriched in more differentiated effector ...memory T cells due to repetitive stimulation or these cells may be absent due to failure to ...
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Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages.
... CD4 T cell epitope are highly activated and ...and effector function of virus-specific CD4 T cells in the ...infiltrating cells, without affecting the cellular composition ...on ...
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1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients.
... autoreactive T cells to play a pivotal role in disease pathogenesis ...regulatory T cells (Tregs) as essential ‘‘masters of immune regulation’’ [4], because they can potently and selectively ...
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Distinct kinetics of effector CD8(+) cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice
... BALB/c (A) or C57BL/6 (B) mice were challenged 30 days before the in vivo cytotoxic assay was performed with bloodstream trypomasti- gotes of T. cruzi as described in the legend to Fig. 1. Two days earlier, ...
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NS1 specific CD8+ T-cells with effector function and TRBV11 dominance in a patient with parvovirus B19 associated inflammatory cardiomyopathy.
... This patient presented with signs and symptoms suggestive of acute myocarditis [6,11]. DCMi was confirmed by immunohistology [12,21], in the absence of active myocarditis according to the histological Dallas criteria ...
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Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naive T cells into cytokine-producing mature T cells.
... T cells have been classified as belonging to the Th1 or Th2 subsets according to the production of defining cytokines such as IFN-c and ...regulatory T cells shifted the simple concept of the ...
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The impact of Lactobacillus plantarum WCFS1 teichoic acid D-alanylation on the generation of effector and regulatory T-cells in healthy mice.
... regulatory T cell in vitro, followed by suppression of experimental autoimmune encephalomyelitis in vivo ...presenting cells by TLRs is also decisive in many essential processes that lead to the development ...
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Crosstalk between immunosuppressive myeloid and effector lymphoid cells in the tumour microenvironment
... γδ T cells can promote recruitment of small peritoneal macrophages (SPM: CD11b + F4/80 int ) that, in turn, lead to increased tumour proliferation (Rei et ...γδ T cells were proposed to induce ...
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