Experimental colitis
Protein tyrosine phosphatase 1B deficiency ameliorates murine experimental colitis via the expansion of myeloid-derived suppressor cells.
... murine experimental colitis as inflammatory animal model, we found that, compared with wild-type littermates, PTP1B-null mice demonstrated greater resistance to DSS- induced colitis, as reflected by ...
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Enhanced mucosal re-epithelialization induced by short chain fatty acids in experimental colitis
... In experimental colonic anastomosis, both SCFA and glucose may enhance peri- anastomotic mucosal proliferation (23) and intra-anastomotic resistance ...of colitis, hypertonic glucose failed to promote ...
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The delay in the development of experimental colitis from isomaltosyloligosaccharides in rats is dependent on the degree of polymerization.
... Methodology/Principal Findings: Five-week-old male Wistar rats were given a semi-purified diet with or without 30 g/kg diet of the S-IMO (DP = 3.3), L-IMO (DP = 8.4), or Dex (DP = 1230) for two weeks. Dextran sulfate ...
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CXCR4 antagonist AMD3100 modulates claudin expression and intestinal barrier function in experimental colitis.
... Ulcerative colitis is a gastrointestinal disorder characterized by local inflammation and impaired epithelial ...the experimental colitis was induced by administration of 5% DSS for 7 days, and CXCR4 ...
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Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats
... rendered colitis by the method originally described by Morris et ...of colitis, and the colon was removed aseptically and placed on an ice cold plate and longitudinally ...
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Comparison of selective and non selective cyclo-oxygenase 2 inhibitors in experimental colitis exacerbation: role of leukotriene B4 and superoxide dismutase
... in experimental colitis as well as in human ...in experimental colitis and contribute to the understanding of the mechanisms which nonsteroidal anti-inlammatory drugs provoke colitis ...
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Intraperitoneal but not intravenous cryopreserved mesenchymal stromal cells home to the inflamed colon and ameliorate experimental colitis.
... CD [2] and in TNBS-colitis [16]. TNF-a is regarded as a crucial molecule for the development of the inflammatory process of CD, and the beneficial actions of anti-TNF-a agents reinforces the role of TNF-a in the ...
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The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis.
... DSS-induced colitis was exacerbated in GP-BAR1 2/2 resulting in a higher diarrhea and colonic macroscopic injury scores and intestinal permeability (Figure ...in colitis severity were not due different ...
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Preliminary results of an animal model validation of chronic experimental colitis
... • Increased values of Fecal Hemoglobin, TNF-α and ALP in TNBS groups compared with Sham group • These manifestations are compatible with a correct induction of colitis 8 , 9. • Acute ph[r] ...
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Adoptive transfer of dendritic cells expressing CD11c reduces the immunological response associated with experimental colitis in BALB/c mice.
... In addition, the production of cytokines measured in the supernatants of the splenic cell cultures was closely related to the variations observed in the different populations of TCD4 + cells examined here ( Fig 5 ). ...
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Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis.
... an experimental colitis ...of experimental colitis induced by dextran sulfate sodium (DSS) and showed that IL-6 triggered S100A9 production in CECs, which was mediated through STAT3 ...
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Hemin reduces inflammation associated with TNBS-induced colitis
... Neutrophilic infiltration in this experimental colitis model was indirectly quantitated through an MPO activity assay. MPO concentration was expressed in ng/mL. The colon was weighed and homogenized in ...
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DSS induced colitis in Nef1-mutated mice leading to adenocarcinoma: therapeutic strategies
... Macrophages and dendritic cells in the lamina propria are increased in absolute number and have an activated phenotype in both forms of IBD, but have been studied in greater detail in CD. Production of pro-inflammatory ...
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Ulcerative colitis in northern Portugal and Galicia in Spain
... For each patient several parameters were collected: date and age of diagnosis onset, disease extent, family his- tory of IBD, extraintestinal manifestations, use and response to steroids, immunosuppression, biologic ...
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Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
... Recent reports have provided insight into the role of colitis as a promoter of colorectal tumorigenesis in the AOM/DSS model [24,29]. However, one important question that remains unan- swered is whether these ...
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Promoting in flammatory lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) aggravated intestinal in flammation in mice with experimental acute colitis
... an experimental mouse model ...acute colitis mouse model overexpressing VEGF-C or VEGF-C156S in the colon ...in experimental mice with those of control ...
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A case of ulcerative colitis presenting as pyoderma gangrenosum and lung nodule
... Pyoderma gangrenosum is a phenomenon of cutaneous ulceration where etiology is not well understood. About half of the cases have an associated extracutanoeus manifestation or associated systemic diseases. Most commonly ...
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Faecalibacterium prausnitzii inhibits interleukin-17 to ameliorate colorectal colitis in rats.
... Immature BMDCs were isolated using a protocol modified from previous publications [25,26]. Briefly, both ends of the rat (6 weeks) femur and tibia bones were cut, and the bone marrow flushed out using RPMI-1640 medium ...
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Pseudomembranous colitis in children: Experience of a university hospital in Korea
... Methods : Between November 2003 and July 2007 at the Department of Pediatrics, Dongsan Medical Center, we analyzed the medical records of consecutive patients who received antibiotics in[r] ...
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The JNK inhibitor XG-102 protects against TNBS-induced colitis.
... Activation of caspase-3 is the central event of the major type of cellular apoptosis, and in many cases, it occurs downstream of JNK activation (reviewed by [48]). The almost complete disappearance of cleaved, i.e. ...
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