gene function
Multiple genetic interaction experiments provide complementary information useful for gene function prediction.
... new gene function information, we used gene function prediction perfor- mance as a measure of biological information contained in a genetic interaction ...the function of a gene ...
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A gene wiki for community annotation of gene function.
... Despite the widespread use of Wikipedia for general interest topics, its use for scholarly subjects has been uneven. The potential power of applying the Long Tail model to gene annotation has been previously noted ...
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A Regression-based K nearest neighbor algorithm for gene function prediction from heterogeneous data
... Computational Biology held at Whistler, Canada on December 18th, 2004.. This.[r] ...
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Characterisation of PRKRA and WDR45 gene function, involved in Parkinson's disease
... In part of this thesis, the focus will be on DYT 16 – Young onset dystonia parkinsonism. It is an early onset generalized secondary dystonia with a recessive pattern of inheritance due to a missense mutation -P222L- in ...
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Genetic engineering of Trypanosoma (Dutonella) vivax and in vitro differentiation under axenic conditions.
... Trypanosoma vivax is one of the most common parasites responsible for animal trypanosomosis, and although this disease is widespread in Africa and Latin America, very few studies have been conducted on the parasite’s ...
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Identification of a novel Gig2 gene family specific to non-amniote vertebrates.
... chromosome 8, green spotted puffer fish chromosome 3 and the chromosome of fugu scaffolds 705 & 2110, while the second set includes zebrafish chromosome 5, the chromosome of stickleback group XIII, medaka chromosome ...
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A naturally occurring polymorphism at Drosophila melanogaster Lim3 Locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan.
... in gene transcription, and ...structural gene) and Lim3A levels, and markers significantly associated with Lim3A expression were not in LD with each other or with markers within the gene in a sample ...
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Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
... The gene targeting strategy, combined with a robust skin phenotyping protocol, has allowed immediate establishment of a preliminary connection between a genotype and a ...given gene to the biology of the ...
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Probabilistic protein function prediction from heterogeneous genome-wide data.
... protein function has been shown to improve the accuracy of automated gene annotation ...protein function prediction that integrates protein-protein interaction (PPI) data, gene expression ...
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Systematically differentiating functions for alternatively spliced isoforms through integrating RNA-seq data.
... capturing gene-level functions to a direct SVM model using the same data input at the gene ...mouse gene function prediction performance in 2008, using heterogeneous genomic data including ...
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Effect of transverse aortic constriction on cardiac structure, function and gene expression in pregnant rats.
... Apical myocardial tissue was sampled and stored for gene expression analyses using quantitative real-time polymerase chain reaction as described previously [8]. Nineteen genes with potential relation to cardiac ...
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Molecular cloning and expression analysis of a zebrafish novel zinc finger protein gene rnf141
... potential function of rnf141, we first injected zebrafish embryos with synthetic rnf141 ...shield-specific gene goosecoid was decreased at the shield stage (Figure ...marker gene expression are ...
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Experimental verification of a predicted intronic microRNA in human NGFR gene with a potential pro-apoptotic function.
... Mutations in the PKD1 gene (encoding Polycistin-1) are accounted for the renal cysts formation [59]. Overexpression of PKD1 in Madin-Darby canine kidney (MDCK) cells has led to decreased apoptosis [60] and ...
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Genome-scale metabolic network validation of Shewanella oneidensis using transposon insertion frequency analysis.
... the gene showed high fitness, and no other insertions were ...the gene assignment based on the sequence alignment with the arylsulfate sulfo-transferase pfam PF05935 ...the gene were essential for ...
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Learning transcriptional regulatory relationships using sparse graphical models.
... decomposing gene expression matrix X into two matrices A and P, such that X~AP, where A represents the connectivity network, and P presents the transcrip- tional factor activities ...a gene, and zero value ...
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Development of TAL effector: recombinase fusion proteins for genome engineering
... With the advancing of new techniques and sophisticated bioinformatics design and modelling, the last decade have witnessed the progress of molecular biology leading into a new genomic engineering era (Fehér, Burland, ...
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Molecular characterization and expression of a novel alcohol oxidase from Aspergillus terreus MTCC6324.
... AOx gene containing few mismatch and a deletion of six contiguous stretch of nucleotides from position 685 to 690 coding for two serine residues was prominent when pair wise aligned with un-reviewed conceptually ...
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Long-range autocorrelations of CpG islands in the human genome.
... The applicability of the organizational information also extends to studies of the molecular genetic mechanisms that drive the distribution of CGI. This in part depends on the presumed function of CGI, which in ...
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Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
... the function of atf-6, RNA interference (RNAi) was used to inactivate the ...may function in the same pathway, and that this pathway is partially redundant to the ire-1/xbp-1 ...
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Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells.
... p21 gene (Figure S2), indicating that in these control cells the molecular machinery responsible for inducing COX2 transcription is not ...C) Gene reporter assays in MKN45 (B) and HEK293 (C) cells ...
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