IL-23
The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.
... When IL-1b-polarized Th17 cells were stimulated with IL-23 for 48 h we detected a statistically significant reduction in IL-23- induced IL-17A net production in protective A ...
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Potentially functional polymorphism in IL-23 receptor and risk of acute myeloid leukemia in a Chinese population.
... of IL-12 [6,7]. IL-23 is predominantly produced by antigen- presenting cells in response to microbial or host immune stimuli and is involved in the regulation of immune responses against infections ...
5
Interleukin-23 Receptor Gene Polymorphism May Enhance Expression of the IL-23 Receptor, IL-17, TNF-α and IL-6 in Behcet's Disease.
... The IL-23R gene is located on chromosome 1p31, and its relative ligand interleukin-23 (IL- 23) is a key component of the immune-regulatory pathway ...the IL-23R was associated with ...
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Análise da imuno expressão das proteínas IL-17, IL-23 E RORγt na patogenia da doença periodontal
... eixo IL-23/IL-17 na imunopatogenia da doença periodontal ainda é desconhecido e pouco ...de IL- 17 na patogênese da DP como verificado para a AR, seja pela sua presença em maiores níveis nos ...
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Hepatitis B virus induces IL-23 production in antigen presenting cells and causes liver damage via the IL-23/IL-17 axis.
... the IL-23 signaling ...both IL-23 and IL-23R was remarkably ...of IL-23 were myeloid dendritic cells (mDCs) and ...induces IL-23 secretion in a mannose ...
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Polymorphisms in the Toll-Like Receptor and the IL-23/IL-17 Pathways Were Associated with Susceptibility to Inflammatory Bowel Disease in a Danish Cohort.
... the IL-23 pathway specific subunit (IL-23p19) or subunits shared with IL12 (IL-12p40 and IL12R-β1) were resistant to inflammation, whereas mice deficient in IL-12 pathway specific ...
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Camundongos C57BL/6 deficientes nas citocinas IL-12 e IL-23 vacinados com antígeno do parasita desenvolvem resistência a infecção por Leishmania amazonensis
... nestes grupos de animais foi similar ao grupo controle. Além disto, o grupo controle apresentou redução na população de células NKT no baço e linfonodo comparado com o grupo vacinado sugerindo o papel destas células no ...
2
Evaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phases
... to IL-10) to reduce background staining; primary antibody: di- lution with background reducing diluent specific for each antibody (IL-2 1:500, IL-4 1:1000, IL-10 1:15000, IL-13 1:800, ...
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Associação entre os níveis séricos de potenciais biomarcadores com a presença de fatores relacionados à atividade clínica e ao mau prognóstico em espondiloartrites.
... (IL-17, IL-23, TNF-α, IL-6, IL-1α e PCRus) foram observadas diferenças estatisticamente signifi cativas em comparação aos controles, e os níveis de citocinas estavam mais altos em ...
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Cross-talk between the Immune System and Tuberculosis Pathogenesis; a Review with Emphasis on the Immune Based Treatment
... IFN-γ, IL-12, and IL-18, whereas Th2 development is carried out by another cytokine set including IL-4, IL-5, and ...with IL-6, IL-21, and IL-23 are involved in ...
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Rev. Bras. Reumatol. vol.52 número4 en v52n4a06
... were: IL-17, IL-6, IL-1α, TNF-α, IFN- , and ...(54.8%). IL-17, IL-23, TNF- α, IL-6, IL-1α, and US-CRP levels were signifi cantly higher in patients with SpA when ...
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Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis.
... the IL- 12/Th1 pathway and IL-23/Th17 pathway in loss of tolerance in our well-defined xenobiotic-induced murine model of PBC in mice immunized with 2-octynoic acid coupled to bovine serum albumin ...
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Efeito do número de EPIYA-C da proteína CagA de Hellicobacter pylori na concentração gástrica de citocinas associadas à resposta Th17 em pacientes com gastrite e carcinoma gástrico
... Nos pacientes com carcinoma gástrico, além das citocinas IL-11, IL-17, IL-23, as concentrações gástricas de IL-6 e TGF-β também se associaram com infecção por amostras contendo [r] ...
8
Implication of TLR- but not of NOD2-signaling pathways in dendritic cell activation by group B Streptococcus serotypes III and V.
... Progress has been achieved in recent years regarding our understanding of the complex interactions between GBS and DCs, especially in the context of type III GBS infection. However, due to limited information, it was ...
20
Quando anti-TNF não obtém sucesso, anti-IL-12-23 é opção alternativa na psoríase e na artrite psoriásica.
... de IL-12 mRNA) na pele de pacientes com Ps. IL-23 é fundamental para a sobrevivência e proliferação de células ...de IL-17; portanto, são células Th17, e um cenário consiste em considerar Ps ...
3
Braz. j. . vol.83 número1
... the IL-17-IL-23 axis plays important roles in the pathogenesis of ...that IL-17A was positively related to both IL-8 and MPO expression, sug- gesting that IL-17 may be related to ...
7
Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface
... (15). IL-23 contributes to the proliferation and differentiation of Th17 cells, and promotes the secretion of IL-17, making up the so-called IL-17/IL-23 ...of IL-23 ...
6
Evaluation of Chosen Cytokine Levels among Patients with Herpes Zoster as Ability to Provide Immune Response.
... (e.g. IL-2, IL-6, IL-10, IFN-γ and TNF-α), but the oth- ers are an ongoing focus of ...of IL-17, IL-21 and IL-23 in patients with HZ have not been ...serum IL-4 and ...
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AVALIAÇÃO DE CITOCINAS PLASMÁTICAS ASSOCIADAS AO SOBREPESO E OBESIDADE EM MULHERES ADULTAS E IDOSAS
... 37 gordura sobre a forma de triglicerídeos, oferece proteção mecânica contra choques, funciona como isolante térmico e ganhou destaque em estudos recentes devido a descoberta de sua função endócrina com a secreção de ...
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RESPOSTA IMUNOLÓGICA DO TIPO TH17 E SUA REPERCUSSÃO CLÍNICA NO LÚPUS ERITEMATOSO SISTÊMICO
... da IL-17 (CHEN; O’SHEA, ...A IL-17 consiste em uma família de seis citocinas estruturalmente relacionadas, algumas das quais provem danos teciduais em doenças de hipersensibilidade e outras são importantes ...
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