plus-maze
Hippocampal histamine receptors and conflictive exploration in the rat: studies using the elevated asymmetric plus-maze
... addition to 9 nmol of histamine in order to identify the possible type of histamine receptor involved. Histamine administration significantly inhibited the exploration score and increased the permanency score at the ...
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Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze
... elevated plus-maze is a widely used animal model of anxiety involving uncondi- tioned responses based on ...elevated plus- maze, the chronic effect of the drug on this model has not been ...
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Memory-impairing effects of local anesthetics in an elevated plus-maze test in mice
... The local anesthetics of the ester class procaine and dimethocaine injected icv into mice of both sexes prolonged the latency to move from the open to the one enclosed arm of the elevated plus-maze. ...
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Anxiogenic effects of Tabernaemontana solanifolia A. DC. (Apocynaceae) extracts in rats tested in the elevated plus-maze
... Elevated Plus Maze Model (EPM): diazepam has long been known to have anxiolytic effects in rats tested in the EPM. As can be seen in table 1, we also found the administration of diazepam to have a ...
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Behavioral profiles displayed by rats in an elevated asymmetric plus-maze: effects of diazepam
... natural tendency to explore, and behavioral parameters related to fear are simple to de- tect. In certain types of environments rats face a conflictive exploration, e.g., their tendency to explore is in conflict with ...
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Paradoxical increase of exploratory behavior in the elevated plus-maze by rats exposed to two kinds of aversive stimuli
... Albino rats were submitted to a 24-h period of social isolation (individual housing) combined with 0, 1, 2 or 3 twenty-four-hour periods of exposure to different vivaria (novelty) and tested in the elevated ...
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The interaction of housing condition and acute immobilization stress on the elevated plus-maze behaviors of protein-malnourished rats
... elevated plus-maze (EPM) (11,12) and elevated T-maze (13) tests showed behavioral alterations that have been interpreted as lower anxiety levels and/or higher ...
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The relationship between anxiety and depression in animal models: a study using the forced swimming test and elevated plus-maze
... These negative results can be explained by the following hypotheses: a) the method- ology employed is inadequate to measure the anxiety-depression association; b) the models used are not adequate for this kind of study, ...
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206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze
... rats placed in activity cages for 15 min. These animals were previously tested to evaluate the effects of vehicle or SB 206553 in the plus-maze test. In each strain, the experimental groups were found to ...
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Corticosterone does not change open elevated plus maze-induced antinociception in mice
... enclosed arms), an animal model of anxiety (Handley and Mithani, 1984; Lister, 1987; Pellow et al., 1985), activates the HPA axis, leading to an enhancement of plasma corticosterone (Rodgers et al., 1999). The EPM test ...
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Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests
... Additionally, in the present study, a characteristic in- verted U-shaped dose-response curve for anandamide was observed in both the open field and elevated plus- maze. Other studies have shown the ...
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Rev. bras. farmacogn. vol.20 número6
... Considering the folk use of Erythrina as an anxiolytic plant and that this effect has been described in experimental studies with different Erythrina species (Onusic et al., 2002; Dantas et al., 2004; Ribeiro et al., ...
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Rev. bras. farmacogn. vol.19 número4
... Figure 2. Anxiolytic-like effects of DZP and EER upon permanence time of open and closed arms on the elevated plus-maze test (n = 10, each). Values represent mean ± S.E.M. Asterisks (*) represent signiicant ...
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Rev. bras. farmacogn. vol.21 número6
... elevated plus-maze test, a decrease in total time of interaction in social interaction test, a decrease in time of latency for the animal to start swimming and a decrease of the minimum convulsant dose ...
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Effects of elevated calcium on motor and exploratory activities of rats
... elevated plus-maze test was con- ducted as described in ...The plus-maze was elevated 50 cm above the ...elevated plus-maze facing one of the open arms, with the number of ...
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Braz. J. Pharm. Sci. vol.50 número1
... MAO inhibition has been described as a possible anticonvulsant mechanism of action of some agents. In addition, MAO inhibition is also implied in sedative properties (Kohli et al., 1967). This fact is in accordance with ...
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Arq. NeuroPsiquiatr. vol.69 número6
... elevated plus maze (EPM) is a test of unconditioned anxiety-related behavior that in- volves a conlict between the rodent’s desire to explore a novel environment and anxiogenic elements such as eleva- tion ...
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POTENCIAL ANTIDEPRESSIVO DO TIMOL: EFEITOS SOBRE OS NÍVEIS DO FATOR NEUROTRÓFICO DERIVADO DO CÉREBRO (BDNF) NO MODELO DE ESTRESSE CRÔNICO INDUZIDO POR CORTICOSTERONA EM CAMUNDONGOS
... y-maze, plus-maze, placa perfurada para averiguar, dentre outros parâmetros, a ansiedade, memória, depressão e ...perfurada, plus-maze e interação ...
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CD73 is a major regulator of adenosinergic signalling in mouse brain.
... elevated plus-maze, open field and light-dark explo- ...(Y maze), nociception (hot plate), motor coordination and motor learning, or in fear- ...
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Psychol. Neurosci. vol.6 número3
... Simvastatin is one of many hydroxymethylglutaryl-coenzyme-A reductase inhibitors that are prescribed to lower cholesterol. Some emerging evidence indicates that classical music can serve as an effective adjuvant in rats ...
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