PROMOTER HYPERMETHYLATION
THE ABERRANT PROMOTER HYPERMETHYLATION PATTERN OF THE ANTI - ANGIOGENIC TSP1 GENE IN EPITHELIAL OVARIAN CARCINOMA: AN INDIAN STUDY
... The promoter hypermethylation patterns of Thrombospodin-1 gene in 50 EOC patients were studied and the methylation pattern was correlated with various clinic pathological ...The promoter ...
9
CDHI promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer
... CDH1 promoter methylation was not uni- formly associated with the loss of E-cadherin ...than promoter hypermethylation, such as allele loss (LOH), gene mutation, changes in chromatin structure [43], ...
9
SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients.
... identified. Hypermethylation of the SOCS3 promoter has been associated with a poor outcome for ...that hypermethylation of the SOCS3 promoter predicts an improved prognosis for GBM ...
5
Promoter hypermethylation of KLF4 inactivates its tumor suppressor function in cervical carcinogenesis.
... the hypermethylation pattern of the KLF4 promoter region was variable among several types of ...KLF4 promoter methylation was reported in the 2156 to 239 bp region relative to the ATG ...KLF4 ...
10
Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.
... of promoter regions is a well known mechanism of gene inactivation and suppression of gene expression, we investigated whether it was responsible for the lowered expression of SGK1 in colorectal ...SGK1 ...
7
Promoter Hypermethylation and Decreased Expression of Syncytin-1 in Pancreatic Adenocarcinomas.
... Bisulfite sequencing was performed as a confirmatory measure for characterization of the syn- cytin-1 gene methylation patterns. We determined the DNA site-specific methylation status in the cancer tissues and normal ...
17
Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomas.
... by promoter hypermethylation 19 years ago [8], it has become increasingly apparent that tumor suppressor promoter methylation has a significant role in the clonal evolution of cancer ...by ...
10
Promoter DNA hypermethylation and gene repression in undifferentiated Arabidopsis cells.
... CpG hypermethylation in the cell suspensions, but were fully unmethy- lated in all the differentiated tissues studied, the CACTA-like transposons (At1g43840, At2g13160, At2g12980) exhibited dense methylation of ...
10
Inactivation of COX2 , HMLH1 and CDKN2A gene by promoter methylation in gastric cancer : relationship with histological subtype, tumor location and helicobacter pylori genotype
... gene promoter hypermethylation [11, 13] ...indicating hypermethylation in promot- er regions of genes COX-2 , CDKN2A and HMLH1 as an important mechanism of gene silencing and suppression of their ...
11
Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation.
... and promoter hypermethylation plays a role, but the evidence for this is not ...targeted promoter methylation and expression analysis to identify potential pathways in serrated ...with ...
10
Co-localization of the oncogenic transcription factor MYCN and the DNA methyl binding protein MeCP2 at genomic sites in neuroblastoma.
... suggesting that the MYCN and MeCP2 could co-operate to modulate the expression of JUNB. Our own ChIP-chip analysis of JUNB in the Kelly cell line reveals several putative overlapping MYCN and MeCP2 binding sites around ...
13
Transcriptional Auto-Regulation of RUNX1 P1 Promoter.
... P1 promoter and the ...the promoter and the UTR RUNX sites in sonicated chromatin was confirmed by real time ...on promoter and UTR RUNX motifs D) Equivalent amount of chromatin (3U OD260) from ...
17
Identification of a single-nucleotide insertion in the promoter region affecting the sodC promoter activity in Brucella neotomae.
... predicted promoter region of ...potential promoter region of ...sodC promoter variants and the b-galactosidase expression in the corresponding recombinant bacteria was ...
11
Linking Core Promoter Classes to Circadian Transcription.
... Eukaryotic core promoters are often thought to have an inactive ground state, assured by a tendency for nucleosomes to cover promoter DNA. In this ground state, the TSS is assumed to be covered by a nucleosome ...
32
Nucleosomes are stably evicted from enhancers but not promoters upon induction of certain pro-inflammatory genes in mouse macrophages.
... IL12B promoter prior to induction even when we extended our analysis to include up to ...IL12B promoter in the population of cells (Figure 1), which was confirmed by histone ChIP experiments (Figure ...
14
Regulation of transgene expression in genetic immunization
... I promoter/enhancer was used to drive luciferase in two different promoters and, as seen in Table 2, caused different luciferase ...SV40 promoter or some inhibitory effect by the neomycin gene product, as ...
8
Role of mannose-binding lectin deficiency in HIV-1 and schistosoma infections in a rural adult population in Zimbabwe.
... All statistical analysis were done using Stata 11 statistical package (STATA Corp, Timberlake Consultants). Normality of plasma MBL levels was checked graphically. Non-parametric tests (Mann-Whitney and Kruskal-Wallis) ...
23
Prediction by promoter logic in bacterial quorum sensing.
... pLac promoter; for negative feedback, we expressed the repressor LacI downstream of an additional copy of pR, and placed the entire construct in a LacI- deleted ...the promoter logic function of pR contains ...
14
Efficient construction of an inverted minimal H1 promoter driven siRNA expression cassette: facilitation of promoter and siRNA sequence exchange.
... Background. RNA interference (RNAi), mediated by small interfering RNA (siRNA), is an effective method used to silence gene expression at the post-transcriptional level. Upon introduction into target cells, siRNAs ...
7
Regulation of ALF promoter activity in Xenopus oocytes.
... core promoter elements such as the TATA box and were important for developing methods of oocyte preparation and microinjection ...core promoter recognition factors like TBP, TFIIA, and TAFs ...cell ...
12