Spindle assembly checkpoint
An overview of the spindle assembly checkpoint status in oral cancer
... the spindle assembly checkpoint ...mitotic checkpoint complex. Mitotic checkpoint complex (MCC) sequesters Cdc20 preventing activation of the anaphase promoting complex/cyclosome ...
9
When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses.
... the spindle midzone in ana- and telophase ...the spindle assembly checkpoint ...the spindle midzone in the vast majority (97%) of bipolar anaphase cells (Figure ...
13
Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint.
... the spindle assembly checkpoint ...tension-sensing checkpoint proteins at metaphase kinetochores upon LIC2 ...in checkpoint inactivation for LIC2 in comparison to its close homolog ...
18
Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.
... mitotic spindle by recruiting a discrete set of conserved kMAPs and ...the spindle assembly checkpoint -recruited by the conserved Ndc80 complex- to misaligned kinetochores allowing cells ...
15
Absence of the spindle assembly checkpoint restores mitotic fidelity upon loss of sister chromatid cohesion
... The fidelity of mitosis depends on cohesive forces that keep sister chromatids together. This is mediated by cohesin that embraces sister chromatid fibers from the time of their replication until the subsequent mitosis ...
12
DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.
... the spindle assembly checkpoint (SAC), which responds to defects in spindle attachment/ tension during metaphase of mitosis and meiosis, are critical for preventing genome insta- ...
28
In-silico modeling of the mitotic spindle assembly checkpoint.
... change checkpoint function in the same way. For the essential checkpoint proteins, Mad2 and Cdc20, we present the mutation effect on our model in detail in Figure 4 for the Convey ...(B). Spindle ...
11
Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.
... microtubule assembly, such as nocodazole, causes cell- cycle arrest in pro-metaphase [7], but the molecular details behind such event are not completely ...with spindle poisons could occur independently of ...
9
The spindle assembly checkpoint: new insights into its function, regulation and therapeutic implications
... Para responder ao segundo objetivo, e numa perspetiva terapêutica, exploramos o papel da proteína Spindly como potencial alvo terapêutico no tratamento do cancro. A Spindly é uma proteína necessária para a localização da ...
209
Dynein-dependent transport of spindle assembly checkpoint proteins off kinetochores toward spindle poles
... Bub3 is a crucial kinetochore partner of Bub1 and BubR1 that is required for efficient kinetochore-microtubule attachments [12]. Bub3 forms part of the MCC; binds to the recently identified pro- tein BuGZ [13,14] and is ...
9
Emerging Pathway of Kinetochore Assembly
... the spindle assembly checkpoint under certain ...The checkpoint mechanism functions normally in the absence of survivin or aurora B function if microtubules are completely disassembled by ...
17
Topography-specific spindle frequency changes in Obstructive Sleep Apnea
... each spindle, and information from all scalp regions was pooled ...median spindle frequency was analyzed, spindle frequency was further treated as a uni- modal variable, so no information about a ...
12
Small molecule inhibitor of formin homology 2 domains (SMIFH2) reveals the roles of the formin family of proteins in spindle assembly and asymmetric division in mouse oocytes.
... Then the question rose how SMIFH2 inhibits spindle formation by inhibiting mDia and/or other proteins of the formin family. It is known that SMIFH2 targets the FH2 domain of for- mins with a half-maximal inhibitor ...
15
Clathrin is spindle-associated but not essential for mitosis.
... Consequently, we have used a chicken pre-B lymphoma cell line DT40, which was generated with endogenous alleles for CHC replaced by human CHC under the control of a tetracycline- regulatable promoter, in order to ...
6
MIPS Assembly Language Programming
... When a label appears alone on a line, it refers to the following memory location. Therefore, we could also write this with the label main on its own line. This is often much better style, since it allows the use of long, ...
97
Checkpoint mitótico como alvo terapêutico para sensibilizar células cancerígenas a agentes antimitóticos
... O checkpoint no final da fase G1, também denominado ponto de restrição, assegura a integridade do DNA antes deste ser replicado durante a fase S ...O checkpoint da fase S assegura que a replicação do DNA é ...
76
Biennial World Health Assemblies
... transferring powers fundamentally vested in the World Health Assembly, the Health Assembly could, by separate resolution, as part of each biennial appropriation resol[r] ...
22
Proof-Carrying Code Based Tool for Secure Information Flow of Assembly Programs
... SPARC assembly programs for secure information ...SPARC assembly language. An alternative option to produce SPARC assembly program directly is to use the option- S with GCC ...
9
Gene projects: A genome Web tool for ongoing mining and annotation applied to CitEST
... At the same time, there are different kinds of informa- tion related to genome projects that can be produced and utilized during the process of assembly and annotation of the genome. For example, there is a strong ...
7
The land assembly problem revisited
... We have implicitly assumed that there are no externalities. Speci…cally, if the developer buys the lot owned by player 1, then the reservation value of player 2’s block is unchanged at w 2 (and vice-versa). This ...
15