Via do PI3K/Akt
HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription.
... the PI3K/Akt ...phenotype, PI3K and Akt are involved in this ...M- Akt protein also released ...activates PI3K directly or via ...between PI3K and Akt and ...
11
ESTUDO DA VIA DE SINALIZAÇÃO PI3K-Akt E GSK3β EM CARCINOMAS EPIDERMOIDES METASTÁTICOS E NÃO METASTÁTICOS DE CAVIDADE BUCAL
... -Ser9, AKT total e pmTOR2448 foram significantemente maiores no grupo de CEB comparado ao grupo controle, sugerindo que essas proteínas podem estar relacionadas com o desenvolvimento e progressão do ...proteínas ...
82
Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2.
... for PI3K/Akt signaling in the regulation of the inflammatory response in diseases including rheumatoid arthritis [20], multiple sclerosis [21], asthma [22], and atherosclerosis ...[25] via ...
12
IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K/Akt pathway.
... 5. PI3K/Akt mediates IGF-1 induced Brn-4 expression in vitro IGF-1, acting via the IGF-1 receptor (IGF1R), is known to regulate diverse aspects of cellular physiology via the phosphoinositide ...
19
Expressão proteica da via PI3K/AKT/mTOR em mastocitomas cutâneos caninos
... A via PI3K/AKT/mTOR está relacionada com a proliferação, síntese proteica, sobrevivência e motilidade das ...nesta via tem sido associadas com o processo carcinogênico de diferentes tipos ...a ...
115
Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3β Signaling Pathways in HT22 Hippocampal Neurons.
... that PI3K/Akt/Bad/Bcl signaling pathway involved in Aβ-induced neuronal apo- ptosis in rat cortex ...by PI3K/Akt signaling pathway ...apoptosis via PI3K/Akt/GSK3β ...
18
Alpha-linolenic acid exerts an endothelial protective effect against high glucose injury via PI3K/Akt pathway.
... Several important observations were made in the present study. First, our data indicated that in vivo treatment with ALA inhibited endothelial inflammation, as manifested by decreased circulating levels of endothelial ...
7
Inibição da via PI3K-Akt em gliomas
... de Akt MK 2206 em combinação com irradiação (RT) e TMZ em um painel de células de gliomas ...de Akt e fosfo Akt foi checada via & ...chave Akt na via PI3K, diminuindo ...
76
Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat.
... Methods and Results: SD rats were fed high fructose (65%) diet alone or along with raw garlic homogenate (250 mg/kg/ day) or nutrient-matched (65% corn starch) control diet for 8 weeks. Fructose-fed diabetic rats showed ...
8
Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.
... activate Akt while PI3K is negatively regulated by the tumor suppressor gene PTEN, which has been shown to be non- functional in 20 to 40% of GBM ...[33–36]. Akt is over-activated in many ...
12
Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cells.
... 4-OH-E2 has been implicated in transforming MCF-10A cells via ROS formation based on inhibition of anchorage independent growth of MCF-10A cells [24]. This study did not show in vivo tumor formation of transformed ...
16
Avaliação da eficácia da terapia fotodinâmica mediada pela alumínio cloro ftalocianina - AlPHCl - lipossomal no tratamento de células derivadas do câncer bucal e sua atuação na regulação da via de sinalização PI3K/AKT/mTOR
... a via envolvendo PI3K é crucial na regulação da sobrevivência ao estresse celular, e dado que os tumores frequentemente existem em um ambiente de estresse metabólico, com limitado suprimento de oxigênio, e ...
77
Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression.
... autophagy. PI3K is an upstream regulatory factor in AKT ...Activated AKT phosphorylates the downstream mTOR, which plays a central role in cell hypertrophy, growth, and survival and protein synthesis ...
16
“Via de sinalização mTOR no carcinoma urotelial da bexiga”
... A via de sinalização PI3K/AKT/mTOR tem sido ligada à tumorogénese em muitos tipos de carcinomas, nomeadamente nos CUB (Nawroth et alii ...da via AKT/PI3K/mTOR são muito ...
83
Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway.
... of PI3K/Akt/mTOR ...of PI3K/Akt/mTOR pathway, suggesting the role of both autophagy and apoptosis in AG–4 induced ...apoptosis via suppression of ...
29
Análises celulares e moleculares dos efeitos do peptídeo vasoativo angiotensina-(1-7) no processo tumoral pulmonar e a atuação do microrna 21-5P
... pela via de PI3K/Akt (CHAKRABORTI et ...de PI3K/Akt está diretamente relacionada com o desenvolvimento e progressão de vários tumores, uma vez que transdução dos sinais dessa via ...
108
Avaliação dos efeitos biológicos dos inibidores do mTOR associados ou não à radioterapia em linhagem celular de carcinoma do colo do útero
... na via PI3K/AKT/mTOR direta ou indiretamente ...da via PI3K/AKT/mTOR e a combinação com a rapamicina aumentou a morte celular induzida pelo resveratrol ...da AKT, levando ...
65
Low-intensity pulsed ultrasound promotes proliferation and migration of HaCaT keratinocytes through the PI3KAKT and JNK pathways
... The PI3K/AKT and JNK pathways are two important signaling pathways related to proliferation and migration ...the PI3K/AKT pathway ...MM-9 via activation of the PI3K/AKT ...
8
Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease.
... signaling via IRS/ PI3K/Akt pathway may have increased NMDA receptor conductance and/or AMPA receptor ...of PI3K/Akt pathway in stimulating LTP [19] and lipoic acid has been shown to ...
18
Propofol pretreatment attenuates lipopolysaccharide-induced acute lung injury in rats by activating the phosphoinositide-3-kinaseAkt pathway
... assayed via lung histological examination. PI3K and p-Akt expression levels in the lung tissue were determined by Western ...increased PI3K and p-Akt expression in the lung tissue of ...
6